How does Ranolazine work to alleviate angina symptoms?
Understand the Problem
The question is asking for an explanation of how the drug Ranolazine functions to relieve symptoms of angina. Specifically, it is seeking to identify the correct mechanism of action from multiple-choice options provided.
Answer
Ranolazine blocks late sodium channels to reduce calcium levels, decreasing tension and enhancing blood flow to alleviate angina.
Ranolazine works by blocking late sodium channels, preventing an increase in cytosolic calcium concentrations. This leads to reduced left ventricular wall tension and increased coronary blood flow, providing relief from angina symptoms.
Answer for screen readers
Ranolazine works by blocking late sodium channels, preventing an increase in cytosolic calcium concentrations. This leads to reduced left ventricular wall tension and increased coronary blood flow, providing relief from angina symptoms.
More Information
Ranolazine's unique mechanism doesn't directly affect heart rate or blood pressure, making it suitable for patients who cannot tolerate other angina medications that do.
Tips
A common mistake is assuming Ranolazine affects heart rate or blood pressure, which it does not.
Sources
- Ranolazine - StatPearls - NCBI Bookshelf - ncbi.nlm.nih.gov
- Ranolazine: A Contemporary Review | Journal of the American ... - ahajournals.org
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