How does pertussis toxin affect G-proteins?
Understand the Problem
The question is asking about the effects of pertussis toxin on G-proteins, specifically how it modifies the function of these proteins. It presents multiple choices to clarify the impact on G-proteins, focusing on biochemical interaction and inhibition.
Answer
Pertussis toxin ADP-ribosylates G-protein alpha subunits, disrupting receptor interaction.
Pertussis toxin affects G-proteins by catalyzing the ADP-ribosylation of specific G-protein alpha subunits of the Gi family, preventing receptor-G-protein interaction.
Answer for screen readers
Pertussis toxin affects G-proteins by catalyzing the ADP-ribosylation of specific G-protein alpha subunits of the Gi family, preventing receptor-G-protein interaction.
More Information
ADP-ribosylation by pertussis toxin modifies the G-protein, leading to the inability to interact with receptors, affecting various signaling pathways.
Tips
A common mistake is misunderstanding the specific G-protein affected; it primarily affects the Gi family.
Sources
- Pertussis Toxin - an overview | ScienceDirect Topics - sciencedirect.com
- Pertussis toxin - Wikipedia - en.wikipedia.org
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