GPCR, cAMP, PKA, CREB
Understand the Problem
The question consists of key biological terms related to cell signaling pathways, specifically involving G-protein-coupled receptors (GPCR), cyclic adenosine monophosphate (cAMP), protein kinase A (PKA), and cAMP response element-binding protein (CREB). It seems to seek information or clarification about how these components interact within a biological context.
Answer
GPCR activation increases cAMP, activates PKA, which phosphorylates CREB, leading to gene transcription.
The GPCR-adenylate cyclase-cAMP-PKA-CREB pathway begins with the activation of GPCR by a hormone, which stimulates adenylate cyclase, increasing cAMP production. cAMP activates PKA, which then phosphorylates and activates CREB, leading to transcription of target genes.
Answer for screen readers
The GPCR-adenylate cyclase-cAMP-PKA-CREB pathway begins with the activation of GPCR by a hormone, which stimulates adenylate cyclase, increasing cAMP production. cAMP activates PKA, which then phosphorylates and activates CREB, leading to transcription of target genes.
More Information
This signaling pathway is crucial in diverse biological processes, including cell growth and differentiation. It is relevant in cancer biology due to its influence on cell proliferation and migration.
Tips
A common mistake is to confuse the order of activation, particularly the sequence from cAMP to PKA and then to CREB. Ensuring the correct order is crucial.
Sources
- cAMP Signaling in Cancer: A PKA-CREB and EPAC-Centric Approach - ncbi.nlm.nih.gov
- The Cyclic AMP Pathway - PMC - NCBI - ncbi.nlm.nih.gov
- Complex roles of cAMP–PKA–CREB signaling in cancer - ehoonline.biomedcentral.com
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