1. DNA molecular interactions (a) Draw the 5′-monophosphate-2′-deoxy-cytosine (dC) nucleotide covalently bonded with neighboring DNA nucleotides, similar to the chalkboard drawing... 1. DNA molecular interactions (a) Draw the 5′-monophosphate-2′-deoxy-cytosine (dC) nucleotide covalently bonded with neighboring DNA nucleotides, similar to the chalkboard drawing for 5′-monophosphate-2′-deoxy-adenosine (dA). (b) Include hydrogens for the hydrogen bond donating groups of the base. (c) Add lone pair electrons for hydrogen bond accepting groups of the base. (d) How many hydrogen bonds can the base group make with its Watson-Crick-Franklin partner? (e) How many VDW contacts can the dC:dG base pair make with other base pairs in dsDNA? Hint: Each atom can make a good VDW contact.
Understand the Problem
The question is asking for detailed drawings and explanations related to the molecular structure and interactions of DNA components, specifically focusing on a specific nucleotide and its bonding properties.
Answer
3 hydrogen bonds; numerous VDW contacts.
The 5′-monophosphate-2′-deoxy-cytosine can form 3 hydrogen bonds with guanine, and the dC:dG base pair can make numerous Van der Waals contacts with other base pairs in DNA.
Answer for screen readers
The 5′-monophosphate-2′-deoxy-cytosine can form 3 hydrogen bonds with guanine, and the dC:dG base pair can make numerous Van der Waals contacts with other base pairs in DNA.
More Information
Cytosine pairs with guanine in DNA, forming three hydrogen bonds. Van der Waals interactions occur between the stacked bases in a DNA helix, contributing to its stability.
Tips
Ensure to correctly identify donating and accepting hydrogen groups while considering electron lone pairs.
Sources
- DNA function & structure (with diagram) - Khan Academy - khanacademy.org
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