Wound Healing and Inflammatory Response Quiz
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Questions and Answers

What is the primary function of granulation tissue during wound healing?

  • To provide a protective barrier over the wound
  • To form a strong, permanent scar tissue
  • To prevent infection by trapping bacteria
  • To secrete growth factors and cytokines that promote healing (correct)
  • What is the main consequence of the inflammatory phase failing to resolve properly?

  • Delayed wound healing
  • Chronic inflammation or autoimmune responses (correct)
  • Wound rupture or dehiscence
  • Excessive scar tissue formation
  • Which of the following is NOT a complication associated with wound healing?

  • Keloid formation
  • Stricture
  • Increased mobility (correct)
  • Fistula
  • What is the primary role of mast cells in the inflammatory response?

    <p>To release histamine and other mediators that promote inflammation (B)</p> Signup and view all the answers

    What is the primary effect of histamine on blood vessels?

    <p>Increased permeability (C)</p> Signup and view all the answers

    Which of the following best describes the role of myofibroblasts in wound healing?

    <p>To contract and remodel scar tissue (B)</p> Signup and view all the answers

    What is the primary function of TGF (transforming growth factor) in wound healing?

    <p>To stimulate the production of collagen (C)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of a keloid scar?

    <p>Usually forms after a minor injury (B)</p> Signup and view all the answers

    Which of the following is NOT a key mediator of inflammation released by platelets during hemostasis?

    <p>Epinephrine (D)</p> Signup and view all the answers

    During the inflammatory process, what is the primary role of neutrophils and macrophages?

    <p>Engulfing pathogens and cellular debris (D)</p> Signup and view all the answers

    What is the primary function of fibroblasts during the proliferative phase of wound healing?

    <p>Secreted collagen and extracellular matrix (C)</p> Signup and view all the answers

    What is the primary function of cytokines in the immune system?

    <p>Signal and regulate immune responses. (D)</p> Signup and view all the answers

    Which of the following processes contributes to the increased vascular permeability seen during inflammation?

    <p>Leakage of proteins and immune cells into the tissues (A)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of the inflammatory phase of wound healing?

    <p>Formation of granulation tissue (D)</p> Signup and view all the answers

    Which of the following is NOT a systemic response to inflammation?

    <p>Decreased erythrocyte sedimentation rate (ESR) (B)</p> Signup and view all the answers

    What is the role of neutrophils in the inflammatory response?

    <p>First responders to infection, performing phagocytosis. (D)</p> Signup and view all the answers

    Which of the following BEST describes the process of chemotaxis during inflammation?

    <p>Movement of immune cells towards the site of injury (D)</p> Signup and view all the answers

    Which of the following white blood cell types are primarily involved in the adaptive immune response?

    <p>Lymphocytes (A)</p> Signup and view all the answers

    Which of the following is the primary function of angiogenesis during wound healing?

    <p>Forming new blood vessels (A)</p> Signup and view all the answers

    Which of the following is a key acute phase protein that plays a role in marking foreign material for phagocytosis?

    <p>C-Reactive Protein (CRP) (A)</p> Signup and view all the answers

    Which of the following is a key difference between tissue regeneration and fibrosis during wound healing?

    <p>Regeneration involves the formation of new tissue, while fibrosis involves scar tissue formation. (A)</p> Signup and view all the answers

    What is a common characteristic of innate immunity?

    <p>Immediate response to pathogens (C)</p> Signup and view all the answers

    What is the primary function of C-Reactive Protein (CRP)?

    <p>Mark foreign material for phagocytosis by immune cells. (B)</p> Signup and view all the answers

    Which of the following is NOT a common cause of immunosuppression?

    <p>Exercise (D)</p> Signup and view all the answers

    What is the characteristic feature of Erythrocyte Sedimentation Rate (ESR) in the context of inflammation?

    <p>Increases significantly. (A)</p> Signup and view all the answers

    Which of the following is an example of a physical barrier in innate immunity?

    <p>Skin (C)</p> Signup and view all the answers

    Which of the following is a key characteristic of neutrophils in the inflammatory response?

    <p>Short lifespan and rapid response. (D)</p> Signup and view all the answers

    Which of the following correctly describes the process of phagocytosis by neutrophils?

    <p>Recognition, engulfment, and destruction of foreign matter. (B)</p> Signup and view all the answers

    What is the function of inflammatory mediators like prostaglandins (PGs), TNF, and ILs?

    <p>Amplifying the inflammatory response (B)</p> Signup and view all the answers

    Which of the following is a systemic response to infection?

    <p>Fever (D)</p> Signup and view all the answers

    Which of the following is NOT a major category within adaptive immunity?

    <p>Innate Immunity (C)</p> Signup and view all the answers

    What is the primary function of macrophages?

    <p>To destroy pathogens and cellular debris (B)</p> Signup and view all the answers

    Which of the following is a characteristic of Community-Acquired Pneumonia (CAP) caused by S. pneumoniae?

    <p>Often preceded by a viral illness followed by acute onset of high fever, rigors, and productive cough. (A)</p> Signup and view all the answers

    Which of the following cell types is responsible for attacking antigens directly?

    <p>Cytotoxic T cells (CD8 cells) (C)</p> Signup and view all the answers

    Pertussis, a highly contagious respiratory illness, is caused by what type of pathogen?

    <p>Bacteria (C)</p> Signup and view all the answers

    What is the primary difference between T cell immunity and innate immunity?

    <p>T cell immunity is slower to respond but provides long-term protection, while innate immunity is faster but provides short-term protection. (C)</p> Signup and view all the answers

    Which of the following is NOT a common symptom of Mycoplasma pneumonia?

    <p>Productive cough with thick, yellow-green phlegm (B)</p> Signup and view all the answers

    What is the function of helper T cells (CD4 cells) in the immune system?

    <p>Influencing other immune cells and coordinating immune responses (D)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of MRSA (Methicillin-Resistant Staphylococcus aureus)?

    <p>It is a common cause of atypical pneumonia in younger adults. (A)</p> Signup and view all the answers

    Which of the following statements is TRUE regarding the maturation of T cells and B cells?

    <p>T cells mature in the thymus, while B cells mature in the bone marrow, spleen, and lymph nodes. (B)</p> Signup and view all the answers

    Flashcards

    Inflammatory Process

    The body’s response to tissue injury or infection involving multiple steps.

    Vasodilation

    The widening of blood vessels to increase blood flow to an injury site.

    Increased Vascular Permeability

    Allows proteins and immune cells to leak into tissues for healing.

    Chemotaxis

    The movement of white blood cells towards the site of injury due to chemical signals.

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    Phagocytosis

    The process where immune cells engulf and digest pathogens and debris.

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    Hemostasis

    The immediate response to stop bleeding by constricting blood vessels and forming a clot.

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    Proliferative Phase

    The stage in wound healing where new tissue and blood vessels form for repair.

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    Fibroblasts

    Key cells that synthesize collagen and form the extracellular matrix in wound healing.

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    Granulation tissue

    Tissue that secretes growth factors and cytokines during healing.

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    Maturation Phase

    Phase where collagen is reorganized to strengthen the wound, starting 3 weeks after injury.

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    Keloids

    Overgrown scar tissue that results from excessive scarring.

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    Mast Cells

    Cells that initiate inflammation and release histamine and heparin.

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    Histamine

    A vasodilator that increases blood vessel permeability during inflammation.

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    Infection Complications

    Complications that delay healing and can lead to chronic wounds.

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    Chronic Inflammation

    Prolonged inflammation that can lead to further complications.

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    Systemic responses

    Fever, pain, lymphadenopathy, anorexia, sleepiness, lethargy, anemia, and weight loss are systemic reactions.

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    Inflammatory mediators

    Substances like prostaglandins (PGs), TNF, and ILs that trigger inflammatory responses.

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    White Blood Cells (WBC)

    Cells essential for the immune system that combat infections.

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    Neutrophils

    First responders to bacterial infections within white blood cells.

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    Immunosuppression

    Reduced ability of the immune system to fight off infections.

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    Innate Immunity

    The body's first line of defense, involving non-specific responses against pathogens.

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    Adaptive Immunity

    A specific immune response that has memory for pathogens.

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    B lymphocyte immunity

    Also known as humoral immunity, involves B cells in the adaptive immune response.

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    Cytokines

    Signaling molecules released by immune cells to regulate responses.

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    Role of Cytokines

    They attract immune cells and promote healing and inflammation.

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    ESR (Erythrocyte Sedimentation Rate)

    Measures how fast red blood cells settle; indicates inflammation.

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    CRP (C-Reactive Protein)

    Protein produced in response to inflammation; indicates active inflammation.

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    Systemic Inflammation Response

    Body wide responses to inflammation, including fever and increased WBCs.

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    Acute-phase Reactants

    Proteins like CRP that increase in response to inflammation.

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    B lymphocytes

    B cells that mature in bone marrow, spleen, and lymph nodes, involved in antibody production.

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    CD4 cells

    Helper T cells that influence other immune cells and aid in immunity responses.

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    CD8 cells

    Cytotoxic T cells that directly attack and destroy infected cells or antigens.

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    Pertussis

    A highly contagious respiratory disease caused by Bordetella pertussis, leading to severe coughing fits.

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    Community-Acquired Pneumonia (CAP)

    Pneumonia acquired outside of a hospital setting, often caused by Mycoplasma pneumonia.

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    MRSA

    Methicillin-Resistant Staphylococcus aureus, a strain of Staphylococcus aureus resistant to many antibiotics.

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    Mycoplasma pneumonia symptoms

    Milder symptoms like dry cough, fever, and fatigue, often following a viral illness.

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    Study Notes

    Patho Exam 2

    • Chapter 7: Electrolytes
    • Chapter 8: ABGs (pg 150)
    • Chapter 41/42: Picture packet
    • Chapter 9: Inflammation and Wound Healing
      • The Inflammatory Process: The body's response to injury/infection with a multi-step process including:
        • Vasodilation: Blood vessels expand to increase blood flow to the injured area, delivering immune cells and nutrients.
        • Increased Vascular Permeability: Allows proteins, immune cells, and other factors to leak into the tissue for healing.
        • Chemotaxis: White blood cells (like neutrophils & macrophages) move to the injury site guided by chemical signals.
        • Phagocytosis: Immune cells engulf pathogens, dead cells, and debris to clear the infection or injury.
        • Resolution or Repair: Tissue regeneration or fibrosis (scar formation) occurs after pathogen and debris are cleared.
      • Wound Healing: Involves several stages:
        • Hemostasis: Immediate response to stop bleeding by constricting blood vessels and forming a clot (platelets and inflammatory mediators, serotonin, histamine).
        • Inflammatory Phase: The body cleans the wound using immune cells, increasing vasodilation and vascular permeability, and chemotaxis.
        • Proliferative Phase: New tissue (granulation tissue), blood vessels and collagen are formed to repair the damage.
    • Chapter 10: Infectious Diseases
      • WBC (White Blood Cells): Essential components of the immune system responsible for fighting infections. Types include neutrophils, lymphocytes, monocytes/macrophages.
      • Immunosuppression: Decreased ability of the immune system to fight infections due to diseases (HIV/AIDS, cancer), medication (chemotherapy, immunosuppressives), or malnutrition.
      • Innate Immunity: The body's first line of defense with non-specific responses against pathogens. It includes physical barriers, immune cells (neutrophils, macrophages), natural enzymes, and antibacterial secretions.
    • Chapter 11/12:
      • Antigens: Substances recognized by the immune system as foreign or non-self; they trigger immune responses. They are proteins, polysaccharides, or other molecules on pathogens or non-pathogens (pollen).
      • Antigen Function in Immunity: Antigens can be exogenous (from outside the body) or endogenous (from within the body). The immune system reacts to antigens by producing antibodies and activating T-cells.
      • Antibodies (Immunoglobulins): Specialized proteins created by B cells that help fight infection and disease.
      • Monocytes/Macrophages: Arise from white blood cells called monocytes and play a role in destroying bacteria, tumor cells and break down various types of antigens.
    • Additional Diseases: Information about various diseases (SLE, rheumatoid arthritis, infections), their symptoms, causes, and treatments. Topics are chronic systematic, localized, and infectious illnesses.

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    Patho Exam 2 PDF

    Description

    Test your knowledge on the intricate processes of wound healing and the inflammatory response. This quiz covers the roles of various cells, tissue types, and mediators involved in healing. Understand the complications and phases necessary for optimal recovery.

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