Podcast
Questions and Answers
Which type of study design involves the researcher actively intervening to assign exposures?
Which type of study design involves the researcher actively intervening to assign exposures?
- Descriptive observational study
- Analytic observational study
- Experimental study (correct)
- Case-control study
In what way do analytic observational studies differ from descriptive observational studies?
In what way do analytic observational studies differ from descriptive observational studies?
- Descriptive studies are always prospective, while analytic studies are retrospective.
- Descriptive studies aim to identify associations, while analytic studies primarily describe the distribution of diseases.
- Analytic studies only involve a single group of participants.
- Analytic studies test specific hypotheses about exposure-outcome relationships, while descriptive studies focus on describing patterns of disease occurrence. (correct)
A researcher documents a rare and unusual adverse reaction to a new medication in a single patient. This is an example of what kind of study?
A researcher documents a rare and unusual adverse reaction to a new medication in a single patient. This is an example of what kind of study?
- Cross-sectional study
- Case report (correct)
- Case series
- Randomized controlled trial
A physician collects data on ten patients who developed the same rare disease over the past year, detailing their symptoms, treatments, and outcomes. What kind of study is this?
A physician collects data on ten patients who developed the same rare disease over the past year, detailing their symptoms, treatments, and outcomes. What kind of study is this?
What key characteristic defines a randomized controlled trial?
What key characteristic defines a randomized controlled trial?
A researcher aims to determine the prevalence of asthma among school children in a city, surveying a representative sample of students at one point in time. What type of study are they conducting?
A researcher aims to determine the prevalence of asthma among school children in a city, surveying a representative sample of students at one point in time. What type of study are they conducting?
Which study design is best suited to investigate the potential causes of a rare disease?
Which study design is best suited to investigate the potential causes of a rare disease?
Which type of epidemiology primarily focuses on generating hypotheses rather than testing them?
Which type of epidemiology primarily focuses on generating hypotheses rather than testing them?
In observational studies, what distinguishes an analytic approach from a descriptive approach?
In observational studies, what distinguishes an analytic approach from a descriptive approach?
Researchers follow a group of healthy individuals over several years to observe the development of heart disease, recording their diets and exercise habits. What kind of study is this?
Researchers follow a group of healthy individuals over several years to observe the development of heart disease, recording their diets and exercise habits. What kind of study is this?
If a researcher is studying a new disease outbreak and publishes a detailed profile of the first few patients, including their symptoms and medical history, what type of study is this considered?
If a researcher is studying a new disease outbreak and publishes a detailed profile of the first few patients, including their symptoms and medical history, what type of study is this considered?
A study aims to determine the prevalence of asthma among children in a school district at a single point in time. Data is collected through questionnaires distributed to parents. What type of observational study design is this?
A study aims to determine the prevalence of asthma among children in a school district at a single point in time. Data is collected through questionnaires distributed to parents. What type of observational study design is this?
Which of the following study designs is most suitable for investigating the potential causes of a rare disease?
Which of the following study designs is most suitable for investigating the potential causes of a rare disease?
A group of researchers plan to follow a cohort of healthy individuals over 10 years to observe the incidence of cardiovascular disease, while also collecting data on their diet and exercise habits. What is the primary goal of this study?
A group of researchers plan to follow a cohort of healthy individuals over 10 years to observe the incidence of cardiovascular disease, while also collecting data on their diet and exercise habits. What is the primary goal of this study?
What is a key difference between an analytic cross-sectional study and a descriptive cross-sectional study?
What is a key difference between an analytic cross-sectional study and a descriptive cross-sectional study?
In which study design do researchers typically begin by identifying a group of individuals who already have the outcome of interest?
In which study design do researchers typically begin by identifying a group of individuals who already have the outcome of interest?
Which type of epidemiology is MOST suitable for determining the efficacy of a new drug in treating a specific disease?
Which type of epidemiology is MOST suitable for determining the efficacy of a new drug in treating a specific disease?
What is the primary goal of descriptive epidemiology?
What is the primary goal of descriptive epidemiology?
An epidemiologist observes that coffee consumption is statistically associated with a lower risk of a certain type of cancer. What type of epidemiology would be used to evaluate this relationship?
An epidemiologist observes that coffee consumption is statistically associated with a lower risk of a certain type of cancer. What type of epidemiology would be used to evaluate this relationship?
A researcher aims to understand the prevalence of diabetes in different age groups within a city. Which epidemiological approach is MOST appropriate for this study?
A researcher aims to understand the prevalence of diabetes in different age groups within a city. Which epidemiological approach is MOST appropriate for this study?
Which study design is classified as both epidemiologic and observational?
Which study design is classified as both epidemiologic and observational?
What differentiates an experimental epidemiologic study from an analytic epidemiologic study?
What differentiates an experimental epidemiologic study from an analytic epidemiologic study?
A hospital implements a new protocol for post-operative care, including regular coffee administration to patients, aiming to reduce the incidence of postoperative ileus. To evaluate the effectiveness of this new protocol, which type of epidemiological study would be MOST suitable?
A hospital implements a new protocol for post-operative care, including regular coffee administration to patients, aiming to reduce the incidence of postoperative ileus. To evaluate the effectiveness of this new protocol, which type of epidemiological study would be MOST suitable?
Which of the following study designs would be MOST effective in determining if coffee consumption causes a reduction in postoperative ileus?
Which of the following study designs would be MOST effective in determining if coffee consumption causes a reduction in postoperative ileus?
Which of the following best describes the primary goal of descriptive epidemiology?
Which of the following best describes the primary goal of descriptive epidemiology?
In analytic epidemiology, what is the main objective when investigating the relationship between exposure and outcome?
In analytic epidemiology, what is the main objective when investigating the relationship between exposure and outcome?
A researcher is conducting a study to determine if there is a link between a new drug and patient satisfaction. According to the 'Big Picture' concept of analytic epidemiology, what are the exposure and outcome in this scenario?
A researcher is conducting a study to determine if there is a link between a new drug and patient satisfaction. According to the 'Big Picture' concept of analytic epidemiology, what are the exposure and outcome in this scenario?
A study finds that individuals who regularly consume coffee have a lower risk of developing type 2 diabetes. What type of epidemiology is most likely being used in this investigation?
A study finds that individuals who regularly consume coffee have a lower risk of developing type 2 diabetes. What type of epidemiology is most likely being used in this investigation?
Which of the following is NOT a typical application of analytic epidemiology?
Which of the following is NOT a typical application of analytic epidemiology?
A public health department wants to understand the distribution of influenza cases within their county during flu season. Which type of epidemiology would be most appropriate for this task?
A public health department wants to understand the distribution of influenza cases within their county during flu season. Which type of epidemiology would be most appropriate for this task?
A research team is investigating whether a new dietary intervention can reduce the risk of cardiovascular disease. What would be the 'exposure' in this study, according to analytic epidemiology principles?
A research team is investigating whether a new dietary intervention can reduce the risk of cardiovascular disease. What would be the 'exposure' in this study, according to analytic epidemiology principles?
What distinguishes analytic epidemiology from descriptive epidemiology?
What distinguishes analytic epidemiology from descriptive epidemiology?
A case series is published describing five patients who developed a rare form of pneumonia after being treated with a new immunosuppressant drug. What is the MOST likely purpose of this case series?
A case series is published describing five patients who developed a rare form of pneumonia after being treated with a new immunosuppressant drug. What is the MOST likely purpose of this case series?
Which research question is BEST addressed by a cross-sectional study?
Which research question is BEST addressed by a cross-sectional study?
A researcher aims to study the prevalence of diabetes and its association with obesity in a metropolitan city. Which study design is MOST appropriate for this research?
A researcher aims to study the prevalence of diabetes and its association with obesity in a metropolitan city. Which study design is MOST appropriate for this research?
A clinician observes an unexpected therapeutic effect of a drug in two patients with a rare genetic disorder. Which study design would be MOST appropriate for reporting this observation?
A clinician observes an unexpected therapeutic effect of a drug in two patients with a rare genetic disorder. Which study design would be MOST appropriate for reporting this observation?
Which of the following is a key limitation of a case series study design?
Which of the following is a key limitation of a case series study design?
In a cross-sectional study examining the relationship between exercise and heart disease, data on both exercise habits and the presence of heart disease are collected simultaneously. What is a potential limitation of this study design in determining causality?
In a cross-sectional study examining the relationship between exercise and heart disease, data on both exercise habits and the presence of heart disease are collected simultaneously. What is a potential limitation of this study design in determining causality?
A researcher wants to determine the prevalence of anxiety disorders among university students at a specific university. Which study design would be MOST appropriate?
A researcher wants to determine the prevalence of anxiety disorders among university students at a specific university. Which study design would be MOST appropriate?
A case series reports on five patients who developed Stevens-Johnson Syndrome (SJS) after starting a new medication. What conclusion can be drawn based SOLELY on this case series?
A case series reports on five patients who developed Stevens-Johnson Syndrome (SJS) after starting a new medication. What conclusion can be drawn based SOLELY on this case series?
In an analytic cross-sectional study, what does comparing the odds of an outcome between exposed and non-exposed groups help to determine?
In an analytic cross-sectional study, what does comparing the odds of an outcome between exposed and non-exposed groups help to determine?
In the context of odds ratio (OR) interpretation, how should an OR of less than 1 be interpreted?
In the context of odds ratio (OR) interpretation, how should an OR of less than 1 be interpreted?
What type of study design is best suited to measure the prevalence of a disease and associated health behaviours in a population at a single point in time?
What type of study design is best suited to measure the prevalence of a disease and associated health behaviours in a population at a single point in time?
In an analytic cross-sectional study, what calculation is performed after categorizing participants into exposed/not exposed and outcome/no outcome groups?
In an analytic cross-sectional study, what calculation is performed after categorizing participants into exposed/not exposed and outcome/no outcome groups?
In an analytic cross-sectional study, individuals are categorized into four groups: exposed with the outcome (A), exposed without the outcome (B), not exposed with the outcome (C), and not exposed without the outcome (D). How is the odds ratio calculated using these groups?
In an analytic cross-sectional study, individuals are categorized into four groups: exposed with the outcome (A), exposed without the outcome (B), not exposed with the outcome (C), and not exposed without the outcome (D). How is the odds ratio calculated using these groups?
If a study finds an odds ratio (OR) of 1, how should this be interpreted in the context of association between exposure and outcome?
If a study finds an odds ratio (OR) of 1, how should this be interpreted in the context of association between exposure and outcome?
What is a key limitation of descriptive cross-sectional studies regarding the establishment of cause-and-effect relationships?
What is a key limitation of descriptive cross-sectional studies regarding the establishment of cause-and-effect relationships?
In an analytical cross-sectional study examining the relationship between coffee consumption and anxiety levels, researchers find an odds ratio of 0.5. What does this suggest?
In an analytical cross-sectional study examining the relationship between coffee consumption and anxiety levels, researchers find an odds ratio of 0.5. What does this suggest?
Flashcards
Experimental Epidemiology
Experimental Epidemiology
Epidemiology that evaluates the impact of treatments or interventions on disease.
Descriptive Epidemiology
Descriptive Epidemiology
Epidemiology focused on patterns (disease, behaviors).
Analytic Epidemiology
Analytic Epidemiology
Epidemiology studies evaluating relationships between risk/protective factors and disease.
Goal of Experimental Epidemiology
Goal of Experimental Epidemiology
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Goal of Descriptive Epidemiology
Goal of Descriptive Epidemiology
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Goal of Analytic Epidemiology
Goal of Analytic Epidemiology
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Experimental Study Design
Experimental Study Design
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Observational Studies
Observational Studies
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Analytic Epidemiology Goal
Analytic Epidemiology Goal
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Exposure (in Epidemiology)
Exposure (in Epidemiology)
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Outcome (in Epidemiology)
Outcome (in Epidemiology)
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Association (in Epidemiology)
Association (in Epidemiology)
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Statin (example)
Statin (example)
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Disease Outcome (example)
Disease Outcome (example)
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Experimental study
Experimental study
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Observational study
Observational study
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Randomized Controlled Trial
Randomized Controlled Trial
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Descriptive study
Descriptive study
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Analytic study
Analytic study
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Case Report
Case Report
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Case Series
Case Series
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Cross-sectional study
Cross-sectional study
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Epidemiology
Epidemiology
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Descriptive Observational Studies
Descriptive Observational Studies
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Analytic Observational Studies
Analytic Observational Studies
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Cross-sectional Study (Descriptive)
Cross-sectional Study (Descriptive)
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Case-control Study
Case-control Study
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What case series DO
What case series DO
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What case series DON'T do
What case series DON'T do
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Descriptive cross-sectional study
Descriptive cross-sectional study
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Prevalence
Prevalence
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Descriptive Cross-Sectional Study Focus
Descriptive Cross-Sectional Study Focus
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Analytic cross-sectional study
Analytic cross-sectional study
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Odds Ratio (OR)
Odds Ratio (OR)
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Odds outcomeexposed
Odds outcomeexposed
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Odds outcomenot exposed
Odds outcomenot exposed
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OR > 1
OR > 1
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OR < 1
OR < 1
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Study Notes
- PHRM 205 (2024/2025) Lecture 6 covers Epidemiology and Observational Studies I.
- UBC Vancouver is situated on the traditional, ancestral, and unceded territory of the Musqueam people.
- Articles in CANVAS are listed in order of mention during the lecture.
Learning Objectives
- Review classification of epidemiologic study designs and how the study designs arise from types of epidemiology.
- Contrast analytic versus descriptive observational studies.
- Case reports, case series, and descriptive cross-sectional studies are all examples of types of descriptive observational studies.
- Analytic cross-sectional study, cohort study, and case-control study are all types of analytic observational studies
Epidemiology Types and Goals
- Descriptive goal is to examine patterns of disease and health behaviors.
- Analytic goal is to evaluate relationships between risk/protective factors and disease (association).
- The "Big Picture" for Analytic Epidemiology asks, "Is there a relationship?" between an exposure and an outcome.
- Experimental goal is to evaluate the effect of treatment/intervention on disease.
Three Types of Epidemiology Placed Into Epidemiologic Study Design
- Experimental studies are placed into observational studies
- Observational studies branch into two types of studies, being Descriptive and Analytic Studies
Observational Studies Overview
- Individuals are followed/observed in real-world settings
- There is no intervention or exposure assignment by the researcher.
- Observational studies are Descriptive or Analytic.
Descriptive Observational Studies
- Describe occurrence of an outcome, such as a disease.
- Descriptive observational studies do not evaluate an intervention.
- Start with no hypothesis, and end with a possible hypothesis.
- Descriptive observational studies are "hypothesis generating".
Case Reports
- Detailed presentation of one case ('n of 1').
- Case reports record a new or unique condition.
- Case reports describe previously undescribed disease.
- Case reports can show unexpected new therapeutic effects.
- Case reports can report adverse events.
- Case reports do not measure disease incidence, identify risk factors or identify cause of disease.
Case Series
- Detailed presentation of 2 or more cases.
- A case series can report on a new or unique condition.
- A case series can describe previously undescribed diseases.
- A case series can show unexpected new therapeutic effects.
- A case series can report on adverse events.
- A case series will not measure disease incidence, identify risk factors, or identify a cause of disease
Cross-Sectional Study
- Observational design that surveys exposures and/or outcomes at a single point in time ('snapshot').
- Cross-sectional studies can be descriptive, focusing on exposure or disease
- Cross-sectional studies can be analytic, measuring association between exposure and disease.
Descriptive Cross-Sectional Study
- Examines patterns of disease and health behaviors.
- Measures prevalence, not incidence.
Analytic Cross-Sectional study
- Observational design that surveys exposures and/or outcomes at a single point in time ('snapshot').
- Can be descriptive, meaning they can focus on exposure or disease related information
- Can be analytical, meaning they can measure association between exposure and disease
- The temporal sequence of exposure and outcome is impossible to determine since you dont know which occurred first which is a main limitation compared to cohort and case control studies
Analytic Cross-Sectional Study: odds of outcome
- In the context of an analytic cross-sectional study, the odds of an outcome is the ratio of those exposed and have the outcome, those exposured that do not have the outcome.
- The ratio of odds of outcome for those who are exposed to the odds of outcome for those who are not exposed is the “Odds Ratio”
Analyzing Analytic Studies: Odds Ratio(OR)
- Odds Ratio (OR) is calculated as the odds of outcome among the exposed divided by the odds of outcome among the unexposed which equals a/b / c/d = ad/bc.
- In analytic cross-sectional study, exposure and outcome are assessed at the same time.
- The measurement of risk in analytic cross-sectional study is with "odds" instead of risk since its hard to measure in these types of studies
- If OR > 1, exposed group has higher odds of outcome compared to unexposed group (Association)
- If OR = 1, no association
- If OR < 1, exposed group has lower odds of outcome compared to unexposed group (Inverse association)
- Percentage increase (strength of relationship) is calculated by (% increase) = (OR - 1) X 100
- Percentage decrease (strength of relationship) is calculated by (% decrease) = (1 - OR) X 100
Limitation of Analytic Studies:
- Cannot establish temporality
Epidemiological Studies Recap/Summary
- The 2x2 table is set up in order to find exposure to certain phenomenon under study
- Key is knowing which association measures to use with each study design.
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