PHAR 205 L6
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Questions and Answers

Which type of study design involves the researcher actively intervening to assign exposures?

  • Descriptive observational study
  • Analytic observational study
  • Experimental study (correct)
  • Case-control study

In what way do analytic observational studies differ from descriptive observational studies?

  • Descriptive studies are always prospective, while analytic studies are retrospective.
  • Descriptive studies aim to identify associations, while analytic studies primarily describe the distribution of diseases.
  • Analytic studies only involve a single group of participants.
  • Analytic studies test specific hypotheses about exposure-outcome relationships, while descriptive studies focus on describing patterns of disease occurrence. (correct)

A researcher documents a rare and unusual adverse reaction to a new medication in a single patient. This is an example of what kind of study?

  • Cross-sectional study
  • Case report (correct)
  • Case series
  • Randomized controlled trial

A physician collects data on ten patients who developed the same rare disease over the past year, detailing their symptoms, treatments, and outcomes. What kind of study is this?

<p>Case series (C)</p> Signup and view all the answers

What key characteristic defines a randomized controlled trial?

<p>Participants are assigned to different exposure groups based on chance. (B)</p> Signup and view all the answers

A researcher aims to determine the prevalence of asthma among school children in a city, surveying a representative sample of students at one point in time. What type of study are they conducting?

<p>Descriptive cross-sectional study (A)</p> Signup and view all the answers

Which study design is best suited to investigate the potential causes of a rare disease?

<p>Case-control study (C)</p> Signup and view all the answers

Which type of epidemiology primarily focuses on generating hypotheses rather than testing them?

<p>Descriptive epidemiology. (A)</p> Signup and view all the answers

In observational studies, what distinguishes an analytic approach from a descriptive approach?

<p>Analytic studies test specific hypotheses about exposure-outcome relationships, while descriptive studies do not. (B)</p> Signup and view all the answers

Researchers follow a group of healthy individuals over several years to observe the development of heart disease, recording their diets and exercise habits. What kind of study is this?

<p>Cohort study (A)</p> Signup and view all the answers

If a researcher is studying a new disease outbreak and publishes a detailed profile of the first few patients, including their symptoms and medical history, what type of study is this considered?

<p>Case series. (C)</p> Signup and view all the answers

A study aims to determine the prevalence of asthma among children in a school district at a single point in time. Data is collected through questionnaires distributed to parents. What type of observational study design is this?

<p>Descriptive cross-sectional study. (C)</p> Signup and view all the answers

Which of the following study designs is most suitable for investigating the potential causes of a rare disease?

<p>Case-control study. (A)</p> Signup and view all the answers

A group of researchers plan to follow a cohort of healthy individuals over 10 years to observe the incidence of cardiovascular disease, while also collecting data on their diet and exercise habits. What is the primary goal of this study?

<p>To analyze the association between diet and exercise habits and the development of cardiovascular disease. (A)</p> Signup and view all the answers

What is a key difference between an analytic cross-sectional study and a descriptive cross-sectional study?

<p>Analytic studies aim to identify associations between variables, while descriptive studies primarily describe the prevalence of a condition. (B)</p> Signup and view all the answers

In which study design do researchers typically begin by identifying a group of individuals who already have the outcome of interest?

<p>Case-control study. (A)</p> Signup and view all the answers

Which type of epidemiology is MOST suitable for determining the efficacy of a new drug in treating a specific disease?

<p>Experimental (D)</p> Signup and view all the answers

What is the primary goal of descriptive epidemiology?

<p>To examine patterns of disease and health behaviors in populations (A)</p> Signup and view all the answers

An epidemiologist observes that coffee consumption is statistically associated with a lower risk of a certain type of cancer. What type of epidemiology would be used to evaluate this relationship?

<p>Analytic (D)</p> Signup and view all the answers

A researcher aims to understand the prevalence of diabetes in different age groups within a city. Which epidemiological approach is MOST appropriate for this study?

<p>Descriptive (C)</p> Signup and view all the answers

Which study design is classified as both epidemiologic and observational?

<p>Descriptive (D)</p> Signup and view all the answers

What differentiates an experimental epidemiologic study from an analytic epidemiologic study?

<p>Experimental studies involve intervention, while analytic studies observe associations. (D)</p> Signup and view all the answers

A hospital implements a new protocol for post-operative care, including regular coffee administration to patients, aiming to reduce the incidence of postoperative ileus. To evaluate the effectiveness of this new protocol, which type of epidemiological study would be MOST suitable?

<p>Experimental (C)</p> Signup and view all the answers

Which of the following study designs would be MOST effective in determining if coffee consumption causes a reduction in postoperative ileus?

<p>An experimental study randomizing post-operative patients to receive either coffee or a placebo, then comparing rates of ileus. (B)</p> Signup and view all the answers

Which of the following best describes the primary goal of descriptive epidemiology?

<p>To examine the patterns of diseases and health behaviors in populations. (C)</p> Signup and view all the answers

In analytic epidemiology, what is the main objective when investigating the relationship between exposure and outcome?

<p>To evaluate the causal link between risk/protective factors and the disease. (D)</p> Signup and view all the answers

A researcher is conducting a study to determine if there is a link between a new drug and patient satisfaction. According to the 'Big Picture' concept of analytic epidemiology, what are the exposure and outcome in this scenario?

<p>Exposure: new drug; Outcome: patient satisfaction (D)</p> Signup and view all the answers

A study finds that individuals who regularly consume coffee have a lower risk of developing type 2 diabetes. What type of epidemiology is most likely being used in this investigation?

<p>Analytic epidemiology (C)</p> Signup and view all the answers

Which of the following is NOT a typical application of analytic epidemiology?

<p>Describing the demographic characteristics of individuals with a specific disease. (D)</p> Signup and view all the answers

A public health department wants to understand the distribution of influenza cases within their county during flu season. Which type of epidemiology would be most appropriate for this task?

<p>Descriptive epidemiology (B)</p> Signup and view all the answers

A research team is investigating whether a new dietary intervention can reduce the risk of cardiovascular disease. What would be the 'exposure' in this study, according to analytic epidemiology principles?

<p>The implementation of the new dietary intervention. (B)</p> Signup and view all the answers

What distinguishes analytic epidemiology from descriptive epidemiology?

<p>Analytic epidemiology evaluates relationships between exposures and outcomes, while descriptive epidemiology examines patterns of disease. (D)</p> Signup and view all the answers

A case series is published describing five patients who developed a rare form of pneumonia after being treated with a new immunosuppressant drug. What is the MOST likely purpose of this case series?

<p>To report an adverse event associated with the new immunosuppressant drug. (C)</p> Signup and view all the answers

Which research question is BEST addressed by a cross-sectional study?

<p>Is there an association between current smoking habits and the prevalence of asthma in a population? (C)</p> Signup and view all the answers

A researcher aims to study the prevalence of diabetes and its association with obesity in a metropolitan city. Which study design is MOST appropriate for this research?

<p>Cross-sectional study (A)</p> Signup and view all the answers

A clinician observes an unexpected therapeutic effect of a drug in two patients with a rare genetic disorder. Which study design would be MOST appropriate for reporting this observation?

<p>Case series (B)</p> Signup and view all the answers

Which of the following is a key limitation of a case series study design?

<p>It cannot establish the incidence of a disease. (B)</p> Signup and view all the answers

In a cross-sectional study examining the relationship between exercise and heart disease, data on both exercise habits and the presence of heart disease are collected simultaneously. What is a potential limitation of this study design in determining causality?

<p>It is difficult to determine if exercise preceded the development of heart disease. (C)</p> Signup and view all the answers

A researcher wants to determine the prevalence of anxiety disorders among university students at a specific university. Which study design would be MOST appropriate?

<p>A cross-sectional study. (D)</p> Signup and view all the answers

A case series reports on five patients who developed Stevens-Johnson Syndrome (SJS) after starting a new medication. What conclusion can be drawn based SOLELY on this case series?

<p>The medication is likely associated with Stevens-Johnson Syndrome (SJS), warranting further investigation. (B)</p> Signup and view all the answers

In an analytic cross-sectional study, what does comparing the odds of an outcome between exposed and non-exposed groups help to determine?

<p>The association between the exposure and the outcome. (C)</p> Signup and view all the answers

In the context of odds ratio (OR) interpretation, how should an OR of less than 1 be interpreted?

<p>There is an inverse association, meaning the exposed group has lower odds of the outcome. (D)</p> Signup and view all the answers

What type of study design is best suited to measure the prevalence of a disease and associated health behaviours in a population at a single point in time?

<p>Descriptive cross-sectional study. (B)</p> Signup and view all the answers

In an analytic cross-sectional study, what calculation is performed after categorizing participants into exposed/not exposed and outcome/no outcome groups?

<p>Determining the odds of the outcome in the exposed group, the odds of the outcome in the non-exposed group, and then calculating the odds ratio. (D)</p> Signup and view all the answers

In an analytic cross-sectional study, individuals are categorized into four groups: exposed with the outcome (A), exposed without the outcome (B), not exposed with the outcome (C), and not exposed without the outcome (D). How is the odds ratio calculated using these groups?

<p>OR = (A/B) / (C/D) (C)</p> Signup and view all the answers

If a study finds an odds ratio (OR) of 1, how should this be interpreted in the context of association between exposure and outcome?

<p>There is no association between the exposure and the outcome. (B)</p> Signup and view all the answers

What is a key limitation of descriptive cross-sectional studies regarding the establishment of cause-and-effect relationships?

<p>They assess exposure and outcome simultaneously, making it difficult to determine temporal relationships. (B)</p> Signup and view all the answers

In an analytical cross-sectional study examining the relationship between coffee consumption and anxiety levels, researchers find an odds ratio of 0.5. What does this suggest?

<p>Coffee consumption might be associated with a lower likelihood of anxiety. (D)</p> Signup and view all the answers

Flashcards

Experimental Epidemiology

Epidemiology that evaluates the impact of treatments or interventions on disease.

Descriptive Epidemiology

Epidemiology focused on patterns (disease, behaviors).

Analytic Epidemiology

Epidemiology studies evaluating relationships between risk/protective factors and disease.

Goal of Experimental Epidemiology

To evaluate effect of treatment/intervention on disease.

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Goal of Descriptive Epidemiology

To examine patterns (of disease, health behaviors)

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Goal of Analytic Epidemiology

To evaluate relationships between risk or protective factors and disease.

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Experimental Study Design

A study design in which the researcher intervenes and manipulates exposure to potential risk or protective factors.

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Observational Studies

A study design in which the researcher observes and analyzes existing patterns without intervening.

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Analytic Epidemiology Goal

Aims to identify connections or links between an exposure and a specific outcome.

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Exposure (in Epidemiology)

A potential factor (e.g., drug, intervention, policy) that may influence an outcome.

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Outcome (in Epidemiology)

A health-related event or condition that is being studied (e.g., disease, clinical measure).

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Association (in Epidemiology)

A connection or relationship between an exposure and an outcome.

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Statin (example)

Medication to lower cholesterol.

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Disease Outcome (example)

The occurrence of a disease, such as cancer.

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Experimental study

A study design where the researcher intervenes to change something.

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Observational study

A study design where the researcher observes without intervention.

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Randomized Controlled Trial

An experimental study where participants are randomly assigned to groups.

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Descriptive study

An observational study focused on describing characteristics of a population.

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Analytic study

An observational study focused on identifying associations and causes.

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Case Report

A detailed report of a single interesting case.

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Case Series

A compilation of multiple case reports with similar characteristics.

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Cross-sectional study

Study that examines data from a population at one specific point in time.

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Epidemiology

The study of the distribution and determinants of health-related states or events (including disease), and the application of this study to the control of diseases and other health problems.

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Descriptive Observational Studies

Observational studies that describe the characteristics of a population or phenomenon. Useful for generating hypotheses.

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Analytic Observational Studies

Observational studies that analyze relationships between variables to test a hypothesis.

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Cross-sectional Study (Descriptive)

A study that examines the relationship between diseases (or other health-related characteristics) and other variables of interest as they exist in a defined population at one particular time

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Case-control Study

A type of observational study in which two existing groups differing in outcome are identified and compared on the basis of some supposed causative attribute

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What case series DO

Report a new or unique condition, describe a previously undescribed disease, show unexpected therapeutic effect or report adverse events.

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What case series DON'T do

Measure disease incidence, identify risk factors or identify the cause of the disease.

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Descriptive cross-sectional study

Examines patterns of disease or health behaviors.

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Prevalence

Measures the proportion of a population with a disease or condition at a specific time.

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Descriptive Cross-Sectional Study Focus

Focus is on exposure or disease.

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Analytic cross-sectional study

Analyzes the association between exposure and outcome at a single point in time.

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Odds Ratio (OR)

The likelihood of an event occurring in one group compared to another.

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Odds outcomeexposed

The odds of an outcome among the exposed group.

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Odds outcomenot exposed

The odds of an outcome among the unexposed group.

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OR > 1

Exposed group has higher odds of outcome.

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OR < 1

Exposed group has lower odds of outcome.

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Study Notes

  • PHRM 205 (2024/2025) Lecture 6 covers Epidemiology and Observational Studies I.
  • UBC Vancouver is situated on the traditional, ancestral, and unceded territory of the Musqueam people.
  • Articles in CANVAS are listed in order of mention during the lecture.

Learning Objectives

  • Review classification of epidemiologic study designs and how the study designs arise from types of epidemiology.
  • Contrast analytic versus descriptive observational studies.
  • Case reports, case series, and descriptive cross-sectional studies are all examples of types of descriptive observational studies.
  • Analytic cross-sectional study, cohort study, and case-control study are all types of analytic observational studies

Epidemiology Types and Goals

  • Descriptive goal is to examine patterns of disease and health behaviors.
  • Analytic goal is to evaluate relationships between risk/protective factors and disease (association).
  • The "Big Picture" for Analytic Epidemiology asks, "Is there a relationship?" between an exposure and an outcome.
  • Experimental goal is to evaluate the effect of treatment/intervention on disease.

Three Types of Epidemiology Placed Into Epidemiologic Study Design

  • Experimental studies are placed into observational studies
  • Observational studies branch into two types of studies, being Descriptive and Analytic Studies

Observational Studies Overview

  • Individuals are followed/observed in real-world settings
  • There is no intervention or exposure assignment by the researcher.
  • Observational studies are Descriptive or Analytic.

Descriptive Observational Studies

  • Describe occurrence of an outcome, such as a disease.
  • Descriptive observational studies do not evaluate an intervention.
  • Start with no hypothesis, and end with a possible hypothesis.
  • Descriptive observational studies are "hypothesis generating".

Case Reports

  • Detailed presentation of one case ('n of 1').
  • Case reports record a new or unique condition.
  • Case reports describe previously undescribed disease.
  • Case reports can show unexpected new therapeutic effects.
  • Case reports can report adverse events.
  • Case reports do not measure disease incidence, identify risk factors or identify cause of disease.

Case Series

  • Detailed presentation of 2 or more cases.
  • A case series can report on a new or unique condition.
  • A case series can describe previously undescribed diseases.
  • A case series can show unexpected new therapeutic effects.
  • A case series can report on adverse events.
  • A case series will not measure disease incidence, identify risk factors, or identify a cause of disease

Cross-Sectional Study

  • Observational design that surveys exposures and/or outcomes at a single point in time ('snapshot').
  • Cross-sectional studies can be descriptive, focusing on exposure or disease
  • Cross-sectional studies can be analytic, measuring association between exposure and disease.

Descriptive Cross-Sectional Study

  • Examines patterns of disease and health behaviors.
  • Measures prevalence, not incidence.

Analytic Cross-Sectional study

  • Observational design that surveys exposures and/or outcomes at a single point in time ('snapshot').
  • Can be descriptive, meaning they can focus on exposure or disease related information
  • Can be analytical, meaning they can measure association between exposure and disease
  • The temporal sequence of exposure and outcome is impossible to determine since you dont know which occurred first which is a main limitation compared to cohort and case control studies

Analytic Cross-Sectional Study: odds of outcome

  • In the context of an analytic cross-sectional study, the odds of an outcome is the ratio of those exposed and have the outcome, those exposured that do not have the outcome.
  • The ratio of odds of outcome for those who are exposed to the odds of outcome for those who are not exposed is the “Odds Ratio”

Analyzing Analytic Studies: Odds Ratio(OR)

  • Odds Ratio (OR) is calculated as the odds of outcome among the exposed divided by the odds of outcome among the unexposed which equals a/b / c/d = ad/bc.
  • In analytic cross-sectional study, exposure and outcome are assessed at the same time.
  • The measurement of risk in analytic cross-sectional study is with "odds" instead of risk since its hard to measure in these types of studies
  • If OR > 1, exposed group has higher odds of outcome compared to unexposed group (Association)
  • If OR = 1, no association
  • If OR < 1, exposed group has lower odds of outcome compared to unexposed group (Inverse association)
  • Percentage increase (strength of relationship) is calculated by (% increase) = (OR - 1) X 100
  • Percentage decrease (strength of relationship) is calculated by (% decrease) = (1 - OR) X 100

Limitation of Analytic Studies:

  • Cannot establish temporality

Epidemiological Studies Recap/Summary

  • The 2x2 table is set up in order to find exposure to certain phenomenon under study
  • Key is knowing which association measures to use with each study design.

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