PHAR 308 Immunology Chapter 1 Learning Outcomes

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Questions and Answers

What is the main function of the immune system?

  • To produce red blood cells
  • To develop hematopoietic stem cells
  • To recognize and protect against infections (correct)
  • To induce protection against smallpox

Who is often attributed as the Father of Immunology?

  • Hematopoietic stem cells
  • Louis Pasteur (correct)
  • Edward Jenner
  • Maryam AlRamadan

What are the two main lineages derived from hematopoietic stem cells in the immune system?

  • Red blood cells and white blood cells
  • Cowpox and smallpox
  • Myeloid and lymphoid lineages (correct)
  • Granulocytes and agranulocytes

What led to the discovery of protection against human smallpox?

<p>Discovery of cowpox-induced protection (A)</p> Signup and view all the answers

Where are hematopoietic stem cells (HSCs) found in adults?

<p>In the bone marrow (B)</p> Signup and view all the answers

Which cells are included in the myeloid cell lineage?

<p>Monocytes, macrophages, neutrophils, and dendritic cells (C)</p> Signup and view all the answers

Which cells are part of the adaptive immune system?

<p>T cells, B cells, and natural killer cells (A)</p> Signup and view all the answers

What is the origin of macrophages?

<p>Blood monocytes that leave the circulation to differentiate in different tissues (D)</p> Signup and view all the answers

What is the function of alveolar macrophages?

<p>Initiation and control of immunity to respiratory pathogens (C)</p> Signup and view all the answers

What type of macrophages are found in the liver?

<p>Kupffer cells (B)</p> Signup and view all the answers

What do macrophages use to detect products of bacteria and other microorganisms?

<p>Recognition receptors such as Toll-like receptors (TLRs) (D)</p> Signup and view all the answers

What is the role of MBL and CRP plasma proteins?

<p>Binding specifically to different pathogen components like sugars (LPS), RNA, DNA, or extracellular proteins (D)</p> Signup and view all the answers

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