PHAR 505 Fall 2022-2023: Mechanism of Action
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Questions and Answers

Which of the following is a potential complication of abrupt withdrawal from long-term corticosteroid therapy?

  • Cushing's syndrome
  • Hyperglycemia
  • Osteoporosis
  • Adrenal crisis (correct)
  • Which of the following is a potential adverse effect of long-term, supraphysiological doses of corticosteroids?

  • Thrombocytopenia
  • Hypoglycemia
  • Immunosuppression (correct)
  • Hyperkalemia
  • Corticosteroids are used in the treatment of which of the following conditions?

  • Congenital adrenal hyperplasia (correct)
  • Alzheimer's disease
  • Parkinson's disease
  • Schizophrenia
  • Which of the following is a potential local adverse effect of inhaled corticosteroids?

    <p>Dysphonia (hoarseness)</p> Signup and view all the answers

    Corticosteroids are used in the treatment of which of the following conditions?

    <p>All of the above</p> Signup and view all the answers

    Which of the following is a potential systemic adverse effect of inhaled corticosteroids, although uncommon?

    <p>All of the above</p> Signup and view all the answers

    What is the most severe complication of steroid cessation?

    <p>Acute adrenal insufficiency</p> Signup and view all the answers

    Which of the following is NOT a complication of continued use of supraphysiological glucocorticoid doses?

    <p>Decreased blood pressure</p> Signup and view all the answers

    What is a common withdrawal symptom associated with corticosteroid cessation?

    <p>Fever and myalgia</p> Signup and view all the answers

    What is the characteristic habitus seen in individuals experiencing steroid overdose?

    <p>Acne and hirsutism</p> Signup and view all the answers

    Which complication is NOT associated with continued use of corticosteroids?

    <p>Hypoglycemia</p> Signup and view all the answers

    What is the major clinical use of glucocorticoids?

    <p>Reducing inflammation and suppressing the immune system</p> Signup and view all the answers

    Which of the following is a mechanism by which corticosteroids protect against life-threatening inflammatory responses?

    <p>Blocking production and release of cytokines</p> Signup and view all the answers

    What physiological action do corticosteroids have on metabolism?

    <p>+Increase in protein breakdown and lipolysis</p> Signup and view all the answers

    'Steroid myopathy' results from what effect of prolonged glucocorticoid excess?

    <p>-Skeletal muscle wasting</p> Signup and view all the answers

    Which of the following is NOT a potential adverse effect of abrupt discontinuation or rapid withdrawal of glucocorticoids after prolonged use?

    <p>Osteoporosis</p> Signup and view all the answers

    Which of the following is a potential complication of long-term, supraphysiological doses of glucocorticoids?

    <p>Cushing's syndrome</p> Signup and view all the answers

    Which of the following is NOT a therapeutic use of glucocorticoids?

    <p>Induction of labor in pregnant women</p> Signup and view all the answers

    Which of the following statements about the therapeutic use of glucocorticoids is TRUE?

    <p>They can be used to manage certain inflammatory and autoimmune disorders</p> Signup and view all the answers

    Which of the following is a potential adverse effect of long-term, high-dose glucocorticoid therapy?

    <p>Osteoporosis</p> Signup and view all the answers

    Which of the following statements about the physiological effects of cortisol is FALSE?

    <p>It enhances insulin sensitivity</p> Signup and view all the answers

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