PHAR 505 Fall 2022-2023: Mechanism of Action

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Which of the following is a potential complication of abrupt withdrawal from long-term corticosteroid therapy?

Cushing's syndrome

Hyperglycemia

Osteoporosis

Adrenal crisis (correct)

Which of the following is a potential adverse effect of long-term, supraphysiological doses of corticosteroids?

Thrombocytopenia

Hypoglycemia

Immunosuppression (correct)

Hyperkalemia

Corticosteroids are used in the treatment of which of the following conditions?

Congenital adrenal hyperplasia (correct)

Alzheimer's disease

Parkinson's disease

Schizophrenia

Which of the following is a potential local adverse effect of inhaled corticosteroids?

Dysphonia (hoarseness) Signup and view all the answers

Corticosteroids are used in the treatment of which of the following conditions?

All of the above Signup and view all the answers

Which of the following is a potential systemic adverse effect of inhaled corticosteroids, although uncommon?

All of the above Signup and view all the answers

What is the most severe complication of steroid cessation?

Acute adrenal insufficiency Signup and view all the answers

Which of the following is NOT a complication of continued use of supraphysiological glucocorticoid doses?

Decreased blood pressure Signup and view all the answers

What is a common withdrawal symptom associated with corticosteroid cessation?

Fever and myalgia Signup and view all the answers

What is the characteristic habitus seen in individuals experiencing steroid overdose?

Acne and hirsutism Signup and view all the answers

Which complication is NOT associated with continued use of corticosteroids?

Hypoglycemia Signup and view all the answers

What is the major clinical use of glucocorticoids?

Reducing inflammation and suppressing the immune system Signup and view all the answers

Which of the following is a mechanism by which corticosteroids protect against life-threatening inflammatory responses?

Blocking production and release of cytokines Signup and view all the answers

What physiological action do corticosteroids have on metabolism?

+Increase in protein breakdown and lipolysis Signup and view all the answers

'Steroid myopathy' results from what effect of prolonged glucocorticoid excess?

-Skeletal muscle wasting Signup and view all the answers

Which of the following is NOT a potential adverse effect of abrupt discontinuation or rapid withdrawal of glucocorticoids after prolonged use?

Osteoporosis Signup and view all the answers

Which of the following is a potential complication of long-term, supraphysiological doses of glucocorticoids?

Cushing's syndrome Signup and view all the answers

Which of the following is NOT a therapeutic use of glucocorticoids?

Induction of labor in pregnant women Signup and view all the answers

Which of the following statements about the therapeutic use of glucocorticoids is TRUE?

They can be used to manage certain inflammatory and autoimmune disorders Signup and view all the answers

Which of the following is a potential adverse effect of long-term, high-dose glucocorticoid therapy?

Osteoporosis Signup and view all the answers

Which of the following statements about the physiological effects of cortisol is FALSE?

It enhances insulin sensitivity Signup and view all the answers

PHAR 505 Fall 2022-2023: Mechanism of Action

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Questions and Answers

Which of the following is a potential complication of abrupt withdrawal from long-term corticosteroid therapy?

Which of the following is a potential adverse effect of long-term, supraphysiological doses of corticosteroids?

Corticosteroids are used in the treatment of which of the following conditions?

Which of the following is a potential local adverse effect of inhaled corticosteroids?

Corticosteroids are used in the treatment of which of the following conditions?

Which of the following is a potential systemic adverse effect of inhaled corticosteroids, although uncommon?

What is the most severe complication of steroid cessation?

Which of the following is NOT a complication of continued use of supraphysiological glucocorticoid doses?

What is a common withdrawal symptom associated with corticosteroid cessation?

What is the characteristic habitus seen in individuals experiencing steroid overdose?

Which complication is NOT associated with continued use of corticosteroids?

What is the major clinical use of glucocorticoids?

Which of the following is a mechanism by which corticosteroids protect against life-threatening inflammatory responses?

What physiological action do corticosteroids have on metabolism?

'Steroid myopathy' results from what effect of prolonged glucocorticoid excess?

Which of the following is NOT a potential adverse effect of abrupt discontinuation or rapid withdrawal of glucocorticoids after prolonged use?

Which of the following is a potential complication of long-term, supraphysiological doses of glucocorticoids?

Which of the following is NOT a therapeutic use of glucocorticoids?

Which of the following statements about the therapeutic use of glucocorticoids is TRUE?

Which of the following is a potential adverse effect of long-term, high-dose glucocorticoid therapy?

Which of the following statements about the physiological effects of cortisol is FALSE?

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