PHAR 505 Fall 2022-2023: Mechanism of Action
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Questions and Answers

Which of the following is a potential complication of abrupt withdrawal from long-term corticosteroid therapy?

  • Cushing's syndrome
  • Hyperglycemia
  • Osteoporosis
  • Adrenal crisis (correct)

Which of the following is a potential adverse effect of long-term, supraphysiological doses of corticosteroids?

  • Thrombocytopenia
  • Hypoglycemia
  • Immunosuppression (correct)
  • Hyperkalemia

Corticosteroids are used in the treatment of which of the following conditions?

  • Congenital adrenal hyperplasia (correct)
  • Alzheimer's disease
  • Parkinson's disease
  • Schizophrenia

Which of the following is a potential local adverse effect of inhaled corticosteroids?

<p>Dysphonia (hoarseness) (B)</p> Signup and view all the answers

Corticosteroids are used in the treatment of which of the following conditions?

<p>All of the above (D)</p> Signup and view all the answers

Which of the following is a potential systemic adverse effect of inhaled corticosteroids, although uncommon?

<p>All of the above (D)</p> Signup and view all the answers

What is the most severe complication of steroid cessation?

<p>Acute adrenal insufficiency (A)</p> Signup and view all the answers

Which of the following is NOT a complication of continued use of supraphysiological glucocorticoid doses?

<p>Decreased blood pressure (D)</p> Signup and view all the answers

What is a common withdrawal symptom associated with corticosteroid cessation?

<p>Fever and myalgia (A)</p> Signup and view all the answers

What is the characteristic habitus seen in individuals experiencing steroid overdose?

<p>Acne and hirsutism (B)</p> Signup and view all the answers

Which complication is NOT associated with continued use of corticosteroids?

<p>Hypoglycemia (D)</p> Signup and view all the answers

What is the major clinical use of glucocorticoids?

<p>Reducing inflammation and suppressing the immune system (D)</p> Signup and view all the answers

Which of the following is a mechanism by which corticosteroids protect against life-threatening inflammatory responses?

<p>Blocking production and release of cytokines (C)</p> Signup and view all the answers

What physiological action do corticosteroids have on metabolism?

<p>+Increase in protein breakdown and lipolysis (C)</p> Signup and view all the answers

'Steroid myopathy' results from what effect of prolonged glucocorticoid excess?

<p>-Skeletal muscle wasting (A)</p> Signup and view all the answers

Which of the following is NOT a potential adverse effect of abrupt discontinuation or rapid withdrawal of glucocorticoids after prolonged use?

<p>Osteoporosis (C)</p> Signup and view all the answers

Which of the following is a potential complication of long-term, supraphysiological doses of glucocorticoids?

<p>Cushing's syndrome (A)</p> Signup and view all the answers

Which of the following is NOT a therapeutic use of glucocorticoids?

<p>Induction of labor in pregnant women (D)</p> Signup and view all the answers

Which of the following statements about the therapeutic use of glucocorticoids is TRUE?

<p>They can be used to manage certain inflammatory and autoimmune disorders (D)</p> Signup and view all the answers

Which of the following is a potential adverse effect of long-term, high-dose glucocorticoid therapy?

<p>Osteoporosis (C)</p> Signup and view all the answers

Which of the following statements about the physiological effects of cortisol is FALSE?

<p>It enhances insulin sensitivity (B)</p> Signup and view all the answers

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