PHAR 3002 Cerebrospinal Fluid and Blood Brain Barrier

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What is the function of the Cerebrospinal Fluid (CSF) in the brain?

Fills ventricles and forms a thin layer around the brain and spinal cord

How is the Blood Brain Barrier (BBB) important for the brain?

It limits the entry of compounds into the brain's extracellular fluid (ECF

What is the volume of cerebrospinal fluid (CSF) produced each day?

500 mls

How do concentrations of solutes in the brain's extracellular fluid (ECF) fluctuate?

<p>With neuronal activity</p> Signup and view all the answers

In what way does the CSF influence the composition of the brain's extracellular fluid (ECF)?

<p>By regulating its composition</p> Signup and view all the answers

How are neurones and glial cells separated within the brain's extracellular fluid (ECF)?

<p>By narrow clefts about 20 nm wide</p> Signup and view all the answers

What is the specific gravity of the brain?

<p>1.040</p> Signup and view all the answers

Which structure is responsible for secreting fluid into the ventricles?

<p>Choroid epithelial cells</p> Signup and view all the answers

What is the role of aquaporins (AQP1) in the CSF secretion process?

<p>Facilitate water transport through the cell</p> Signup and view all the answers

Which part of the brain acts as a cushion or shock-absorber?

<p>CSF</p> Signup and view all the answers

What is the specific gravity of the CSF?

<p>1.007</p> Signup and view all the answers

During embryonic development, which structures of the ventricular system are derived from the center of the neural tube?

<p>Interventricular foramina</p> Signup and view all the answers

What is the primary function of CSF in relation to neurones and glia?

<p>Provides appropriate local environment</p> Signup and view all the answers

What causes accumulation of HCO3 in choroid epithelial cells during CSF secretion?

<p>Na+ influx</p> Signup and view all the answers

What could potentially cause physical blockage leading to hydrocephalus?

<p>Foramina of Magendie</p> Signup and view all the answers

What is the primary role of CSF circulation in relation to systemic blood?

<p>Medium of exchange</p> Signup and view all the answers

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