PHAR 3002 Cerebrospinal Fluid and Blood Brain Barrier
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Questions and Answers

What is the function of the Cerebrospinal Fluid (CSF) in the brain?

  • Regulates the composition of the brain's extracellular fluid (ECF)
  • Conditions the extracellular fluid (ECF) through glial cells
  • Fills ventricles and forms a thin layer around the brain and spinal cord (correct)
  • Protects the brain from fluctuations in blood composition

    • How is the Blood Brain Barrier (BBB) important for the brain?

  • It fills the ventricles and forms a thin layer around the brain and spinal cord
  • It regulates the composition of the cerebrospinal fluid (CSF)
  • It limits the entry of compounds into the brain's extracellular fluid (ECF (correct)
  • It influences the composition of the brain's extracellular fluid (ECF)

    • What is the volume of cerebrospinal fluid (CSF) produced each day?

  • 200 mls
  • 500 mls (correct)
  • 300 mls
  • 100 mls

    • How do concentrations of solutes in the brain's extracellular fluid (ECF) fluctuate?

    <p>With neuronal activity</p> Signup and view all the answers

    In what way does the CSF influence the composition of the brain's extracellular fluid (ECF)?

    <p>By regulating its composition</p> Signup and view all the answers

    How are neurones and glial cells separated within the brain's extracellular fluid (ECF)?

    <p>By narrow clefts about 20 nm wide</p> Signup and view all the answers

    What is the specific gravity of the brain?

    <p>1.040</p> Signup and view all the answers

    Which structure is responsible for secreting fluid into the ventricles?

    <p>Choroid epithelial cells</p> Signup and view all the answers

    What is the role of aquaporins (AQP1) in the CSF secretion process?

    <p>Facilitate water transport through the cell</p> Signup and view all the answers

    Which part of the brain acts as a cushion or shock-absorber?

    <p>CSF</p> Signup and view all the answers

    What is the specific gravity of the CSF?

    <p>1.007</p> Signup and view all the answers

    During embryonic development, which structures of the ventricular system are derived from the center of the neural tube?

    <p>Interventricular foramina</p> Signup and view all the answers

    What is the primary function of CSF in relation to neurones and glia?

    <p>Provides appropriate local environment</p> Signup and view all the answers

    What causes accumulation of HCO3 in choroid epithelial cells during CSF secretion?

    <p>Na+ influx</p> Signup and view all the answers

    What could potentially cause physical blockage leading to hydrocephalus?

    <p>Foramina of Magendie</p> Signup and view all the answers

    What is the primary role of CSF circulation in relation to systemic blood?

    <p>Medium of exchange</p> Signup and view all the answers

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