9 Questions
What is a first-line urate lowering agent?
Allopurinol
Which patients are candidates for prophylactic therapy with urate lowering agents?
Patients with recurrent attacks, tophi, CKD stage 2 or worse, or past urolithiasis
How does allopurinol reduce serum uric acid concentrations?
By blocking the enzyme xanthine oxidase
For which patients should urate lowering therapy (ULT) be continued even during acute flares?
Patients with recurrent attacks
What is the primary active metabolite of allopurinol?
Oxypurinol
Which intervention is part of non-pharmacologic therapy for gout prophylaxis?
Strictly limiting ethanol consumption
What is NOT a recommended approach in the pharmacologic therapy for gout prophylaxis?
Administering NSAIDs for all patients with gout
Which of the following is an alternative first-line uricosuric agent?
Probenecid
What should patients do along with maintaining hydration and managing comorbidities for gout prophylaxis?
Strictly limit or discontinue ethanol consumption
Learn about the formation, solubility, excretion pathways and health implications of uric acid in the human body. Understand how high serum concentrations and temperature levels can affect the precipitation of urate crystals.
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