Uric Acid and its Excretion Pathways
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Questions and Answers

What is a first-line urate lowering agent?

  • Colchicine
  • NSAID
  • Allopurinol (correct)
  • Probenecid

    • Which patients are candidates for prophylactic therapy with urate lowering agents?

  • Patients with no history of gout attacks
  • Patients with recurrent attacks, tophi, CKD stage 2 or worse, or past urolithiasis (correct)
  • Patients with recurrent attacks, tophi, CKD stage 1, and no history of urolithiasis
  • Patients with acute gout flare only

    • How does allopurinol reduce serum uric acid concentrations?

  • By promoting the formation of tophi
  • By blocking the enzyme xanthine oxidase (correct)
  • By increasing the production of uric acid
  • By decreasing uric acid excretion

    • For which patients should urate lowering therapy (ULT) be continued even during acute flares?

    <p>Patients with recurrent attacks</p> Signup and view all the answers

    What is the primary active metabolite of allopurinol?

    <p>Oxypurinol</p> Signup and view all the answers

    Which intervention is part of non-pharmacologic therapy for gout prophylaxis?

    <p>Strictly limiting ethanol consumption</p> Signup and view all the answers

    What is NOT a recommended approach in the pharmacologic therapy for gout prophylaxis?

    <p>Administering NSAIDs for all patients with gout</p> Signup and view all the answers

    Which of the following is an alternative first-line uricosuric agent?

    <p>Probenecid</p> Signup and view all the answers

    What should patients do along with maintaining hydration and managing comorbidities for gout prophylaxis?

    <p>Strictly limit or discontinue ethanol consumption</p> Signup and view all the answers

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