Purine Nucleotides Catabolism and Uric Acid
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Questions and Answers

Where does urine acidification occur?

  • Proximal convoluted tubule
  • Glomerulus
  • Collecting duct
  • DCT of the kidney (correct)

What is the metabolic end product of purine nucleotides catabolism?

  • Lactic acid
  • Urea
  • Uric acid (correct)
  • Creatinine

What is another source of uric acid besides purine nucleotides catabolism?

  • Glycolysis
  • De novo synthesis (correct)
  • Glucose-6-phosphatase
  • Krebs cycle

What is the starting material for de novo synthesis of uric acid?

<p>Glucose-6-phosphate (D)</p> Signup and view all the answers

What is another source of uric acid in the body?

<p>Exogenous purines taken in diet (C)</p> Signup and view all the answers

What is a characteristic of Fanconi syndrome?

<p>Decreased reabsorption of uric acid (A)</p> Signup and view all the answers

Which of the following conditions is associated with a decrease in urinary uric acid?

<p>Inherited deficiency of xanthine oxidase enzyme (B)</p> Signup and view all the answers

What is a consequence of renal failure?

<p>Increased serum uric acid and decreased urinary uric acid (C)</p> Signup and view all the answers

Corticosteroids, such as cortisone, can induce a state of:

<p>Catabolism (A)</p> Signup and view all the answers

Which of the following is NOT a cause of increased uric acid production?

<p>Inherited deficiency of xanthine oxidase enzyme (C)</p> Signup and view all the answers

What is recommended to be taken with this substance?

<p>A full glass of water (D)</p> Signup and view all the answers

What is the purpose of taking a full glass of water with this substance?

<p>To inhibit formation of hypoxanthine stones in kidneys (D)</p> Signup and view all the answers

What is the risk associated with not taking a full glass of water with this substance?

<p>Formation of hypoxanthine stones in kidneys (C)</p> Signup and view all the answers

Why is it important to take a full glass of water with this substance?

<p>To reduce the risk of kidney stone formation (B)</p> Signup and view all the answers

What is the benefit of drinking a full glass of water with this substance?

<p>It reduces the risk of hypoxanthine stones in kidneys (D)</p> Signup and view all the answers

What is the primary function of uricase enzyme?

<p>To break down uric acid into a highly soluble compound (A)</p> Signup and view all the answers

Why is uricase enzyme-recombinant (pegloticase) used?

<p>Because it is not found naturally in humans (B)</p> Signup and view all the answers

What is the result of uricase enzyme's action on uric acid?

<p>A highly soluble compound (D)</p> Signup and view all the answers

What is the name of the recombinant uricase enzyme?

<p>Pegloticase (C)</p> Signup and view all the answers

What is the normal source of uricase enzyme in humans?

<p>It is not found naturally in humans (D)</p> Signup and view all the answers

What is the primary medication used to treat acute attacks of gout?

<p>NSAIDs (A)</p> Signup and view all the answers

What is a common side effect of taking colchicine?

<p>Vomiting (C)</p> Signup and view all the answers

What is the volume of urine sample required for the procedure?

<p>20 µl (C)</p> Signup and view all the answers

How long should the sample be incubated before measuring the absorbance?

<p>10 minutes (C)</p> Signup and view all the answers

How is the concentration of the sample calculated?

<p>Concentration = Conc of Std (D)</p> Signup and view all the answers

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