Purine Nucleotides Catabolism and Uric Acid

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Where does urine acidification occur?

Proximal convoluted tubule

Glomerulus

Collecting duct

DCT of the kidney (correct)

What is the metabolic end product of purine nucleotides catabolism?

Lactic acid

Urea

Uric acid (correct)

Creatinine

What is another source of uric acid besides purine nucleotides catabolism?

Glycolysis

De novo synthesis (correct)

Glucose-6-phosphatase

Krebs cycle

What is the starting material for de novo synthesis of uric acid?

Glucose-6-phosphate Signup and view all the answers

What is another source of uric acid in the body?

Exogenous purines taken in diet Signup and view all the answers

What is a characteristic of Fanconi syndrome?

Decreased reabsorption of uric acid Signup and view all the answers

Which of the following conditions is associated with a decrease in urinary uric acid?

Inherited deficiency of xanthine oxidase enzyme Signup and view all the answers

What is a consequence of renal failure?

Increased serum uric acid and decreased urinary uric acid Signup and view all the answers

Corticosteroids, such as cortisone, can induce a state of:

Catabolism Signup and view all the answers

Which of the following is NOT a cause of increased uric acid production?

Inherited deficiency of xanthine oxidase enzyme Signup and view all the answers

What is recommended to be taken with this substance?

A full glass of water Signup and view all the answers

What is the purpose of taking a full glass of water with this substance?

To inhibit formation of hypoxanthine stones in kidneys Signup and view all the answers

What is the risk associated with not taking a full glass of water with this substance?

Formation of hypoxanthine stones in kidneys Signup and view all the answers

Why is it important to take a full glass of water with this substance?

To reduce the risk of kidney stone formation Signup and view all the answers

What is the benefit of drinking a full glass of water with this substance?

It reduces the risk of hypoxanthine stones in kidneys Signup and view all the answers

What is the primary function of uricase enzyme?

To break down uric acid into a highly soluble compound Signup and view all the answers

Why is uricase enzyme-recombinant (pegloticase) used?

Because it is not found naturally in humans Signup and view all the answers

What is the result of uricase enzyme's action on uric acid?

A highly soluble compound Signup and view all the answers

What is the name of the recombinant uricase enzyme?

Pegloticase Signup and view all the answers

What is the normal source of uricase enzyme in humans?

It is not found naturally in humans Signup and view all the answers

What is the primary medication used to treat acute attacks of gout?

NSAIDs Signup and view all the answers

What is a common side effect of taking colchicine?

Vomiting Signup and view all the answers

What is the volume of urine sample required for the procedure?

20 µl Signup and view all the answers

How long should the sample be incubated before measuring the absorbance?

10 minutes Signup and view all the answers

How is the concentration of the sample calculated?

Concentration = Conc of Std Signup and view all the answers