17 Questions
Which stage involves the synthesis of a large number of new compounds in one single process?
High throughput screening
What property is NOT considered for improvement during drug discovery and development?
Color of the compound
Which stage involves selecting the most promising lead compound for further optimization?
Optimized lead synthesis
What is the primary goal of repositioning an old drug?
To target a different indication
Which method involves compounds being synthesized by methods of combinatorial chemistry like 'split and mix' and parallel synthesis?
Combinatorial synthesis
What is the primary focus of bioinformatics approaches in discovering biomolecules of interest?
Storing and analyzing biological data from various sources
How do genetic approaches contribute to biomolecule identification?
Identifying genetic associations with diseases
Which method is commonly used for target identification in proteomics?
Comparing protein expression levels in normal and diseased tissues
What is the main purpose of SAR studies in drug discovery projects?
Modifying or removing functional groups of small molecules
In drug discovery, what is the role of affinity chromatography?
Separate and purify biomolecules based on binding affinity
What emerging tools are used for generating phenotype changes in chemical genomics and proteomics?
Modifying functional groups of small molecules
What is the primary focus of Target-Based Drug Discovery (TBDD)?
Cloning and expressing target proteins for in vitro bioassays
Which type of biomolecule is typically a target in Target-Based Drug Discovery?
Proteins
What is the major challenge when the structure-activity relationship (SAR) is difficult to determine?
Limited understanding of drug mechanism of action
Which historical example demonstrates the discovery of Aspirin as a drug?
Isolation from willow, meadowsweet, and wintergreen
What was the major milestone in Morphine's discovery in the 1800s?
Isolation from opium for sleep induction and pain relief
In drug discovery, what does 'efficacy' refer to?
The beneficial effect of drugs on the disease
Explore the process of discovering a biomolecule of interest by mining available biomedical data using bioinformatics approaches. Learn how to identify biomolecules through mRNA/protein levels analysis and genetic associations.
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