Discovering Biomolecules in Biomedical Data
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Questions and Answers

Which stage involves the synthesis of a large number of new compounds in one single process?

  • Lead optimization
  • Clinical candidate selection
  • High throughput screening (correct)
  • Hit-to-lead optimization

    • What property is NOT considered for improvement during drug discovery and development?

  • Metabolic stability
  • In vivo efficacy
  • Color of the compound (correct)
  • Membrane permeability

    • Which stage involves selecting the most promising lead compound for further optimization?

  • Optimized lead synthesis (correct)
  • High throughput screening
  • Hit-to-lead optimization
  • Clinical candidate selection

    • What is the primary goal of repositioning an old drug?

    <p>To target a different indication</p> Signup and view all the answers

    Which method involves compounds being synthesized by methods of combinatorial chemistry like 'split and mix' and parallel synthesis?

    <p>Combinatorial synthesis</p> Signup and view all the answers

    What is the primary focus of bioinformatics approaches in discovering biomolecules of interest?

    <p>Storing and analyzing biological data from various sources</p> Signup and view all the answers

    How do genetic approaches contribute to biomolecule identification?

    <p>Identifying genetic associations with diseases</p> Signup and view all the answers

    Which method is commonly used for target identification in proteomics?

    <p>Comparing protein expression levels in normal and diseased tissues</p> Signup and view all the answers

    What is the main purpose of SAR studies in drug discovery projects?

    <p>Modifying or removing functional groups of small molecules</p> Signup and view all the answers

    In drug discovery, what is the role of affinity chromatography?

    <p>Separate and purify biomolecules based on binding affinity</p> Signup and view all the answers

    What emerging tools are used for generating phenotype changes in chemical genomics and proteomics?

    <p>Modifying functional groups of small molecules</p> Signup and view all the answers

    What is the primary focus of Target-Based Drug Discovery (TBDD)?

    <p>Cloning and expressing target proteins for in vitro bioassays</p> Signup and view all the answers

    Which type of biomolecule is typically a target in Target-Based Drug Discovery?

    <p>Proteins</p> Signup and view all the answers

    What is the major challenge when the structure-activity relationship (SAR) is difficult to determine?

    <p>Limited understanding of drug mechanism of action</p> Signup and view all the answers

    Which historical example demonstrates the discovery of Aspirin as a drug?

    <p>Isolation from willow, meadowsweet, and wintergreen</p> Signup and view all the answers

    What was the major milestone in Morphine's discovery in the 1800s?

    <p>Isolation from opium for sleep induction and pain relief</p> Signup and view all the answers

    In drug discovery, what does 'efficacy' refer to?

    <p>The beneficial effect of drugs on the disease</p> Signup and view all the answers

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