Discovering Biomolecules in Biomedical Data

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Questions and Answers

Which stage involves the synthesis of a large number of new compounds in one single process?

  • Lead optimization
  • Clinical candidate selection
  • High throughput screening (correct)
  • Hit-to-lead optimization

What property is NOT considered for improvement during drug discovery and development?

  • Metabolic stability
  • In vivo efficacy
  • Color of the compound (correct)
  • Membrane permeability

Which stage involves selecting the most promising lead compound for further optimization?

  • Optimized lead synthesis (correct)
  • High throughput screening
  • Hit-to-lead optimization
  • Clinical candidate selection

What is the primary goal of repositioning an old drug?

<p>To target a different indication (B)</p> Signup and view all the answers

Which method involves compounds being synthesized by methods of combinatorial chemistry like 'split and mix' and parallel synthesis?

<p>Combinatorial synthesis (B)</p> Signup and view all the answers

What is the primary focus of bioinformatics approaches in discovering biomolecules of interest?

<p>Storing and analyzing biological data from various sources (D)</p> Signup and view all the answers

How do genetic approaches contribute to biomolecule identification?

<p>Identifying genetic associations with diseases (B)</p> Signup and view all the answers

Which method is commonly used for target identification in proteomics?

<p>Comparing protein expression levels in normal and diseased tissues (B)</p> Signup and view all the answers

What is the main purpose of SAR studies in drug discovery projects?

<p>Modifying or removing functional groups of small molecules (B)</p> Signup and view all the answers

In drug discovery, what is the role of affinity chromatography?

<p>Separate and purify biomolecules based on binding affinity (D)</p> Signup and view all the answers

What emerging tools are used for generating phenotype changes in chemical genomics and proteomics?

<p>Modifying functional groups of small molecules (D)</p> Signup and view all the answers

What is the primary focus of Target-Based Drug Discovery (TBDD)?

<p>Cloning and expressing target proteins for in vitro bioassays (C)</p> Signup and view all the answers

Which type of biomolecule is typically a target in Target-Based Drug Discovery?

<p>Proteins (D)</p> Signup and view all the answers

What is the major challenge when the structure-activity relationship (SAR) is difficult to determine?

<p>Limited understanding of drug mechanism of action (A)</p> Signup and view all the answers

Which historical example demonstrates the discovery of Aspirin as a drug?

<p>Isolation from willow, meadowsweet, and wintergreen (B)</p> Signup and view all the answers

What was the major milestone in Morphine's discovery in the 1800s?

<p>Isolation from opium for sleep induction and pain relief (C)</p> Signup and view all the answers

In drug discovery, what does 'efficacy' refer to?

<p>The beneficial effect of drugs on the disease (A)</p> Signup and view all the answers

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