23 Questions
What is the main difference between polyclonal and monoclonal antibodies?
Polyclonal antibodies are produced by many plasma cells, while monoclonal antibodies are produced by one type of plasma cell.
How are polyclonal antibodies produced?
By collecting the serum of immunized animals and purifying the antibodies.
What is characteristic of monoclonal antibodies?
They are identical antibodies produced in large quantities by a specific cell line.
Which type of antibodies are less expensive to produce: polyclonal or monoclonal?
Polyclonal antibodies
How do polyclonal antibodies differ from monoclonal antibodies in terms of antigenic recognition?
Polyclonal antibodies recognize multiple antigenic sites of injected antigens, while monoclonal antibodies recognize only one antigenic site.
What is the source for collecting polyclonal antibodies?
Sera of immunized animals
What is a key characteristic of monoclonal antibody production?
Hybridoma cell immortalization
What is a defining characteristic of immunotoxins?
They recognize only one antigenic site
In Radioimmunotherapy, what is the main function of monoclonal antibodies?
To deliver the toxic payload
What distinguishes monoclonal antibodies from polyclonal antibodies in terms of recognition?
Recognize only one antigenic site
Which feature is a notable advantage of monoclonal antibodies over polyclonal antibodies?
Immortalized hybridoma cell line production
What is a key difference between polyclonal and monoclonal antibodies in terms of origin?
Produced by immunizing an animal with antigen
Which type of antibodies is more cost-effective to produce?
"Polyclonal antibodies"
Explain the difference between polyclonal and monoclonal antibodies in terms of recognition of antigenic sites.
Polyclonal antibodies recognize multiple antigenic sites, while monoclonal antibodies recognize only one antigenic site.
What is the key characteristic of immunotoxins?
Immunotoxins are composed of a targeting antibody linked to a toxin.
In Radioimmunotherapy, what is the main role of monoclonal antibodies?
Monoclonal antibodies are used to deliver radiation to specific target cells.
How are polyclonal antibodies produced?
Polyclonal antibodies are produced by immunizing an animal with the appropriate antigen and collecting the serum for antibody purification.
What distinguishes monoclonal antibodies from polyclonal antibodies in terms of production?
Monoclonal antibodies are produced by a cloned and cultured individual B lymphocyte hybridoma, while polyclonal antibodies are collected from the sera of immunized animals.
Explain the concept of polyclonal antibodies being 'less expensive' to produce compared to monoclonal antibodies.
Polyclonal antibodies are less expensive to produce because one antigen induces the production of multiple antibodies in an immunized animal.
What is the source of collecting monoclonal antibodies?
Monoclonal antibodies are collected from the culture media of hybridoma cells.
Describe the antigenic recognition specificity of monoclonal antibodies.
Monoclonal antibodies recognize only one antigenic site of the injected antigen.
What is the defining characteristic of monoclonal antibodies in Radioimmunotherapy?
Monoclonal antibodies are used to target specific antigens on cancer cells for the delivery of radiation therapy.
Explain the significance of using monoclonal antibodies in immunotoxin therapy.
Monoclonal antibodies play a crucial role in immunotoxin therapy by specifically targeting cells of interest for toxin delivery.
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