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Questions and Answers
What is the karyotype of a complete hydatidiform mole?
Which type of mole is compatible with early embryogenesis?
What is the serum HCG level in a complete hydatidiform mole?
What is the risk of subsequent choriocarcinoma in a complete hydatidiform mole?
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What is the characteristic trophoblast proliferation in a complete hydatidiform mole?
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What is the genetic makeup of a partial hydatidiform mole?
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What is the primary cause of gestational trophoblastic disease?
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What is the main difference between complete and partial hydatidiform moles?
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Which of the following is NOT a type of gestational trophoblastic disease?
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What is the function of human chorionic gonadotropin (hCG) in gestational trophoblastic disease?
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What is the term for the abnormal proliferation of fetal/placental trophoblast cells?
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What is the term for the non-malignant lesions that arise from abnormal placental implantation?
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What is the type of trophoblast that is involved in placental implantation site?
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What is the characteristic feature of chorionic villi in hydatidiform moles?
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Study Notes
Complete Hydatidiform Mole
- Results from an empty egg fertilized by two spermatozoa or a diploid sperm, yielding diploid cells with only paternal chromosomes
- Karyotyping: 46,XX or, uncommonly, 46,XY
- Not compatible with embryogenesis, rarely contains fetal parts
- All chorionic villi are abnormal, showing villous edema
- Diffuse (circumferential) trophoblast proliferation
- Serum HCG is elevated
- 2% risk of subsequent choriocarcinoma
Partial Hydatidiform Mole
- Results from a normal egg fertilized by two spermatozoa (heterozygous) or a diploid sperm
- Triploid karyotype with a preponderance of paternal genes
- Karyotyping: 69, XXY
- Compatible with early embryo formation, may contain fetal parts
- Some chorionic villi are normal, some show villous edema
- Focal (slight) trophoblast proliferation
- Serum HCG is less elevated
- Rarely associated with gestational trophoblastic disease
Gestational Trophoblastic Disease
- Heterogeneous group of related lesions arising from abnormal proliferation of fetal/placental trophoblast cells
- Includes complete and partial hydatidiform moles, invasive mole, gestational choriocarcinoma, and placental site trophoblastic tumor
- Products of conception (POC) include chorionic villi, villous trophoblasts, and gestational/decidualized endometrium
- Arias-Stella reaction and placental implantation site features include extravillous trophoblast (EVT) within decidualized endometrium, maternal vascular remodeling, fibrinoid material in decidua, and EVT within vascular wall or lumen
- Human chorionic gonadotropin (hCG) is elevated in blood and urine, used to monitor treatment efficacy
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Description
Learn about the differences between complete and partial hydatidiform moles, including their causes and effects on embryonic development.
