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Questions and Answers
What is the typical presentation of a hydatidiform mole?
What is the typical presentation of a hydatidiform mole?
What is the malignant trophoblastic tumor that can arise from a complete mole?
What is the malignant trophoblastic tumor that can arise from a complete mole?
What is the characteristic ultrasound appearance of a hydatidiform mole?
What is the characteristic ultrasound appearance of a hydatidiform mole?
What is the treatment for a hydatidiform mole?
What is the treatment for a hydatidiform mole?
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What is the rare and aggressive form of gestational trophoblastic disease?
What is the rare and aggressive form of gestational trophoblastic disease?
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What is the potential complication of a molar pregnancy?
What is the potential complication of a molar pregnancy?
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What is the diagnosis of a placental site trophoblastic tumor based on?
What is the diagnosis of a placental site trophoblastic tumor based on?
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What is the treatment for choriocarcinoma?
What is the treatment for choriocarcinoma?
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Study Notes
Hydatidiform Mole
- Also known as molar pregnancy.
- Characterized by the abnormal proliferation of trophoblastic cells.
- Two types: complete mole (46XX or 46XY) and partial mole (69XXX, 69XXY, or 69XYY).
- Presents with vaginal bleeding, enlarged uterus for gestational age, and elevated hCG levels.
- Diagnosis with ultrasound showing a "snowstorm" or "cluster of grapes" appearance.
- Treatment involves dilation and curettage (D&C) and monitoring hCG levels.
Choriocarcinoma
- A malignant trophoblastic tumor.
- Can arise from a complete mole, partial mole, ectopic pregnancy, or even normal pregnancy.
- Presents with symptoms like irregular vaginal bleeding, pelvic pain, and respiratory distress.
- Diagnosis through elevated hCG levels and imaging studies.
- Treatment includes chemotherapy with drugs like methotrexate, etoposide, and cisplatin.
Epithelioid Trophoblastic Tumor
- A rare and aggressive form of gestational trophoblastic disease.
- Composed of epithelioid trophoblastic cells.
- Presents with abnormal vaginal bleeding and an enlarged uterus.
- Diagnosis with histopathology showing epithelioid cells with abundant eosinophilic cytoplasm.
- Treatment involves surgery and chemotherapy.
Placental Site Trophoblastic Tumor
- Rare, indolent form of gestational trophoblastic disease.
- Arises from the implantation site of a previous pregnancy.
- Presents with irregular vaginal bleeding.
- Diagnosis with histopathology showing intermediate trophoblastic cells at the implantation site.
- Treatment includes surgical resection and sometimes chemotherapy.
Molar Pregnancy Complications
- Potential complications of molar pregnancies include:
- Persistent gestational trophoblastic disease (PTD) requiring chemotherapy.
- Risk of developing choriocarcinoma.
- Recurrent molar pregnancies in subsequent pregnancies.
- Increased risk of thyroid dysfunction.
- Risk of uterine perforation during D&C procedure.
- Close monitoring of hCG levels post-molar pregnancy is crucial to detect and manage complications promptly.
Hydatidiform Mole
- Characterized by abnormal proliferation of trophoblastic cells
- Two types: complete mole (46XX or 46XY) and partial mole (69XXX, 69XXY, or 69XYY)
- Presents with vaginal bleeding, enlarged uterus for gestational age, and elevated hCG levels
- Ultrasound diagnosis shows a "snowstorm" or "cluster of grapes" appearance
- Treatment involves dilation and curettage (D&C) and monitoring hCG levels
Choriocarcinoma
- A malignant trophoblastic tumor arising from molar pregnancy, ectopic pregnancy, or normal pregnancy
- Presents with irregular vaginal bleeding, pelvic pain, and respiratory distress
- Diagnosis through elevated hCG levels and imaging studies
- Treatment includes chemotherapy with methotrexate, etoposide, and cisplatin
Epithelioid Trophoblastic Tumor
- A rare and aggressive form of gestational trophoblastic disease
- Composed of epithelioid trophoblastic cells with abundant eosinophilic cytoplasm
- Presents with abnormal vaginal bleeding and an enlarged uterus
- Diagnosis with histopathology showing epithelioid cells
- Treatment involves surgery and chemotherapy
Placental Site Trophoblastic Tumor
- A rare, indolent form of gestational trophoblastic disease arising from the implantation site of a previous pregnancy
- Presents with irregular vaginal bleeding
- Diagnosis with histopathology showing intermediate trophoblastic cells at the implantation site
- Treatment includes surgical resection and sometimes chemotherapy
Molar Pregnancy Complications
- Persistent gestational trophoblastic disease (PTD) requiring chemotherapy
- Risk of developing choriocarcinoma
- Recurrent molar pregnancies in subsequent pregnancies
- Increased risk of thyroid dysfunction
- Risk of uterine perforation during D&C procedure
- Close monitoring of hCG levels post-molar pregnancy is crucial to detect and manage complications promptly
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Description
Learn about Hydatidiform Mole, a type of molar pregnancy characterized by abnormal trophoblastic cell growth, and Choriocarcinoma, a malignant tumor. Understand their symptoms, diagnosis, and treatment.
