Types of Anti-Fungal Agents and Their Mechanism of Action
12 Questions
6 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

Which anti-fungal agent acts by inhibiting ergosterol synthesis through the inhibition of squalene oxidase?

  • Terbinafine (correct)
  • Griseofulvin
  • Caspofungin
  • Flucytosine

Which anti-fungal agent forms a complex with Ergosterol, leading to cytoplasmic leakage and fungal death?

  • Caspofungin
  • Amphotericin B (correct)
  • Itraconazole
  • Fluconazole

Which anti-fungal agent inhibits the enzyme 1,3 D-glucan synthase, thus inhibiting fungal cell wall synthesis?

  • Clotrimazole
  • Itraconazole
  • Caspofungin (correct)
  • Flucytosine

Which anti-fungal agent disrupts fungal cell mitotic spindles, thus preventing fungal cell division?

<p>Griseofulvin (D)</p> Signup and view all the answers

Which anti-fungal agent causes the depletion of ergosterol in the fungal cell membrane by inhibiting the fungal cytochrome p450 3A –dependent C 14demethylase?

<p>Fluconazole (B)</p> Signup and view all the answers

Which type of anti-fungal agent is primarily topical but has an exception that is available as both oral and topical?

<p>Allylamines (A)</p> Signup and view all the answers

How does Amphotericin B cause fungal death?

<p>Formation of a complex with Ergosterol, leading to cytoplasmic leakage (B)</p> Signup and view all the answers

Which anti-fungal agent primarily acts by inhibiting the enzyme 1,3 D-glucan synthase?

<p>Griseofulvin (B)</p> Signup and view all the answers

What is the primary MOA of Flucytosine?

<p>Inhibition of ergosterol synthesis (A)</p> Signup and view all the answers

Which anti-fungal agent inhibits ergosterol synthesis through the inhibition of squalene oxidase?

<p>Terbinafine (C)</p> Signup and view all the answers

Which anti-fungal agent causes the depletion of ergosterol in the fungal cell membrane by inhibiting the fungal cytochrome p450 3A –dependent C 14demethylase?

<p>Fluconazole (A)</p> Signup and view all the answers

How do Allylamines act as anti-fungal agents?

<p>By inhibiting ergosterol synthesis through the inhibition of squalene oxidase (B)</p> Signup and view all the answers

Study Notes

Anti-Fungal Agents

  • Fenbendazole inhibits ergosterol synthesis through the inhibition of squalene oxidase.

Mode of Action

  • Amphotericin B forms a complex with Ergosterol, leading to cytoplasmic leakage and fungal death.
  • Echinocandins inhibit the enzyme 1,3 D-glucan synthase, thus inhibiting fungal cell wall synthesis.
  • Griseofulvin disrupts fungal cell mitotic spindles, thus preventing fungal cell division.

Inhibition of Ergosterol Synthesis

  • Azoles (e.g. Ketoconazole) cause the depletion of ergosterol in the fungal cell membrane by inhibiting the fungal cytochrome p450 3A –dependent C 14 demethylase.

Topical vs. Oral Administration

  • Imidazoles are primarily topical, but one exception, Ketoconazole, is available as both oral and topical.

Fungal Death

  • Amphotericin B causes fungal death by forming a complex with Ergosterol, leading to cytoplasmic leakage.

1,3 D-Glucan Synthase Inhibitors

  • Echinocandins primarily act by inhibiting the enzyme 1,3 D-glucan synthase.

Flucytosine Mode of Action

  • Flucytosine's primary MOA is to inhibit DNA synthesis by converting into a toxic metabolite that inhibits fungal RNA and DNA synthesis.

Squalene Oxidase Inhibitors

  • Fenbendazole inhibits ergosterol synthesis through the inhibition of squalene oxidase.

Azole Mode of Action

  • Azoles cause the depletion of ergosterol in the fungal cell membrane by inhibiting the fungal cytochrome p450 3A –dependent C 14 demethylase.

Allylamine Mode of Action

  • Allylamines act as anti-fungal agents by inhibiting squalene epoxidase, a key enzyme in ergosterol synthesis.

Studying That Suits You

Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

Quiz Team

Related Documents

2.ANTI-FUNGAL AGENTS.pptx

Description

Learn about the 6 major types of anti-fungal agents and their modes of action, including polyenes like Amphotericin B, anti-metabolites like Flucytosine, and azoles that inhibit fungal cytochrome p450 3A –dependent C 14demethylase. Understand how these agents work to combat fungal infections.

More Like This

Anti-Fungals
10 questions

Anti-Fungals

BoundlessObsidian4130 avatar
BoundlessObsidian4130
PCO 401 Dr S S Agboola: Anti-fungal Agents Outlines
20 questions
Antifungal Agents Quiz
12 questions

Antifungal Agents Quiz

SharperEducation9982 avatar
SharperEducation9982
Use Quizgecko on...
Browser
Browser