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Questions and Answers
Which anti-fungal agent acts by inhibiting ergosterol synthesis through the inhibition of squalene oxidase?
Which anti-fungal agent acts by inhibiting ergosterol synthesis through the inhibition of squalene oxidase?
Which anti-fungal agent forms a complex with Ergosterol, leading to cytoplasmic leakage and fungal death?
Which anti-fungal agent forms a complex with Ergosterol, leading to cytoplasmic leakage and fungal death?
Which anti-fungal agent inhibits the enzyme 1,3 D-glucan synthase, thus inhibiting fungal cell wall synthesis?
Which anti-fungal agent inhibits the enzyme 1,3 D-glucan synthase, thus inhibiting fungal cell wall synthesis?
Which anti-fungal agent disrupts fungal cell mitotic spindles, thus preventing fungal cell division?
Which anti-fungal agent disrupts fungal cell mitotic spindles, thus preventing fungal cell division?
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Which anti-fungal agent causes the depletion of ergosterol in the fungal cell membrane by inhibiting the fungal cytochrome p450 3A –dependent C 14demethylase?
Which anti-fungal agent causes the depletion of ergosterol in the fungal cell membrane by inhibiting the fungal cytochrome p450 3A –dependent C 14demethylase?
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Which type of anti-fungal agent is primarily topical but has an exception that is available as both oral and topical?
Which type of anti-fungal agent is primarily topical but has an exception that is available as both oral and topical?
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How does Amphotericin B cause fungal death?
How does Amphotericin B cause fungal death?
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Which anti-fungal agent primarily acts by inhibiting the enzyme 1,3 D-glucan synthase?
Which anti-fungal agent primarily acts by inhibiting the enzyme 1,3 D-glucan synthase?
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What is the primary MOA of Flucytosine?
What is the primary MOA of Flucytosine?
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Which anti-fungal agent inhibits ergosterol synthesis through the inhibition of squalene oxidase?
Which anti-fungal agent inhibits ergosterol synthesis through the inhibition of squalene oxidase?
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Which anti-fungal agent causes the depletion of ergosterol in the fungal cell membrane by inhibiting the fungal cytochrome p450 3A –dependent C 14demethylase?
Which anti-fungal agent causes the depletion of ergosterol in the fungal cell membrane by inhibiting the fungal cytochrome p450 3A –dependent C 14demethylase?
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How do Allylamines act as anti-fungal agents?
How do Allylamines act as anti-fungal agents?
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Study Notes
Anti-Fungal Agents
- Fenbendazole inhibits ergosterol synthesis through the inhibition of squalene oxidase.
Mode of Action
- Amphotericin B forms a complex with Ergosterol, leading to cytoplasmic leakage and fungal death.
- Echinocandins inhibit the enzyme 1,3 D-glucan synthase, thus inhibiting fungal cell wall synthesis.
- Griseofulvin disrupts fungal cell mitotic spindles, thus preventing fungal cell division.
Inhibition of Ergosterol Synthesis
- Azoles (e.g. Ketoconazole) cause the depletion of ergosterol in the fungal cell membrane by inhibiting the fungal cytochrome p450 3A –dependent C 14 demethylase.
Topical vs. Oral Administration
- Imidazoles are primarily topical, but one exception, Ketoconazole, is available as both oral and topical.
Fungal Death
- Amphotericin B causes fungal death by forming a complex with Ergosterol, leading to cytoplasmic leakage.
1,3 D-Glucan Synthase Inhibitors
- Echinocandins primarily act by inhibiting the enzyme 1,3 D-glucan synthase.
Flucytosine Mode of Action
- Flucytosine's primary MOA is to inhibit DNA synthesis by converting into a toxic metabolite that inhibits fungal RNA and DNA synthesis.
Squalene Oxidase Inhibitors
- Fenbendazole inhibits ergosterol synthesis through the inhibition of squalene oxidase.
Azole Mode of Action
- Azoles cause the depletion of ergosterol in the fungal cell membrane by inhibiting the fungal cytochrome p450 3A –dependent C 14 demethylase.
Allylamine Mode of Action
- Allylamines act as anti-fungal agents by inhibiting squalene epoxidase, a key enzyme in ergosterol synthesis.
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Description
Learn about the 6 major types of anti-fungal agents and their modes of action, including polyenes like Amphotericin B, anti-metabolites like Flucytosine, and azoles that inhibit fungal cytochrome p450 3A –dependent C 14demethylase. Understand how these agents work to combat fungal infections.
