Types of Anti-Fungal Agents and Their Mechanism of Action
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Questions and Answers

What is the mechanism of action of Amphotericin B?

  • Inhibition of squalene oxidase
  • Inhibition of fungal cell wall synthesis
  • Formation of a complex with Ergosterol leading to cytoplasmic leakage (correct)
  • Inhibition of the enzyme 1,3 D-glucan synthase

    • Which of the following anti-fungal agents inhibits the fungal cytochrome p450 3A –dependent C 14demethylase?

  • Caspofungin (correct)
  • Amphotericin B
  • Griseofulvin
  • Flucytosine

    • How do Glucan synthesis Inhibitors act as anti-fungal agents?

  • Inhibition of the enzyme 1,3 D-glucan synthase (correct)
  • Inhibition of fungal cell wall synthesis
  • Inhibition of fungal mitotic spindles
  • Inhibition of ergosterol synthesis through the inhibition of squalene oxidase

    • Which anti-fungal agent primarily acts as a topical agent and inhibits ergosterol synthesis through the inhibition of squalene oxidase?

    <p>Terbinafine</p> Signup and view all the answers

    Which type of anti-fungal agent disrupts fungal cell mitotic spindles thus preventing fungal cell division?

    <p>Griseofulvin</p> Signup and view all the answers

    What is the major lipid component of the fungal membrane that forms a complex with Amphotericin B?

    <p>Ergosterol</p> Signup and view all the answers

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