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Bacteriology: Anti-Fungals

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Polyenes (poly-unsaturated organic compounds - Amphotericin B (systemic and topical), Nystatin (topical only))

Bind to sterols and disrupt cell membranes; fungicidal

Zoles (imidazoles and triazoles - Ketoconazole, Clotrimazole, Miconazole, Fluconazole, Itraconazole)

Block ergosterol synthesis: resulting in membrane disruption; fungistatic (fungicidal at high concentrations)

Systemic or topical, depending.

Pyrimidines (5-fluorocytosine/flucytosine)

Inhibits fungal DNA synthesis; used systemically (oral) for systemic infections, fungistatic (-cidal at high concentrations), limited spectrum, rapid resistance, penetrates CNS

Grisans (Griseofulvin)

<p>Inhibits fungal microtubule assembly; blocks mitosis, fungistatic, used orally, only effective vs dermatophytes (ringworm), teratogenic esp in cats</p> Signup and view all the answers

Terbinafine (Lamisil)

<p>Blocks ergosterol synthesis; similar to imidazoles but different mechanism (inhibits squaline, an early precursor to ergosterol)</p> Signup and view all the answers