Uncover the Mechanisms of Antifungal Action

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34 Questions

Which chemical class do most antifungal products belong to?

Azoles

How do Azoles work as antifungals?

They inhibit cytochrome P-450 dependent synthesis of ergosterol

Which enzyme do allylamines inhibit in fungal cells?

Squalene epoxidase

Which sterol do polyenes specifically bind to in fungal cell membranes?

Ergosterol

What is the mechanism of action of pyrimidine analogues as antifungals?

They convert to an antimetabolite chemical

Which of the following is true about cellular toxins?

They are specific to bacteria and yeasts

What is the primary function of Vercom as a disinfectant?

Oxidizing sulphur bonds in proteins and enzymes

Which of the following is used to treat otitis externa in cats and dogs caused by Malassezia?

Terbinafine

What is a potential risk associated with using Posaconazole in cats?

Neurological signs

Which of the following is a licensed treatment for Malassezia skin infection in both cats and dogs?

Miconazole

Which drug is the drug of choice for treating dogs with ringworm?

Itraconazole

Which drug is off-licence in cats and is the drug of choice in cats with ringworm?

Itraconazole

Which drug is commonly used as a systemic treatment for ringworm in horses?

Griseofulvin

Which drug is licensed for the treatment of candidiasis and aspergillosis in non-food producing birds?

Voriconazole

Which drug is used as a skin rinse for ringworm in rabbits and small mammals?

Enilconazole

Which drug is commonly used as a systemic treatment for ringworm in horses?

Griseofulvin

Which drug is licensed for the treatment of candidiasis and aspergillosis in non-food producing birds?

Voriconazole

Which drug is off-licence in cats and is the drug of choice in cats with ringworm?

Itraconazole

Which of the following is used to treat otitis externa in cats and dogs caused by Malassezia?

Chlorhexidine

Which drug is used as a skin rinse for ringworm in rabbits and small mammals?

Enilconazole

Which chemical class of antifungal products inhibits cytochrome P-450 dependent synthesis of ergosterol in fungal cell membranes?

Azoles

What is the mechanism of action of allylamines as antifungals?

Inhibit squalene epoxidase in fungal cells

Which antifungal class specifically binds to ergosterol in fungal cell membranes?

Polyenes

What is the primary function of polyenes as antifungals?

Cause physical change in fungal cell membrane

Which of the following drugs is off-licence and primarily used for the treatment of Malassezia/Pseudomonas resistant infections in cats and dogs?

Silver sulfadiazine

What is the primary function of Chlorhexidine as an antiseptic?

Binding to the skin and forming a protective layer

Which drug is off-licence and associated with neurological and systemic signs in cats and dogs?

Posaconazole

Which drug is used as a topical treatment for otitis externa caused by Malassezia in cats and dogs?

Miconazole

Which drug is licensed for the treatment of Malassezia skin infection in both cats and dogs?

Miconazole

What are the off-licence treatments for ringworm in dogs and cats?

Itraconazole, Ketoconazole, Enilconazole, Miconazole, Chlorhexidine

What are the off-licence treatments for systemic/deep mycoses, cryptococcosis, and urinary candidiasis in cats and dogs?

Amphotericin B, Fluconazole, Flucytosine

What are the off-licence treatments for ringworm in rabbits and small mammals?

Itraconazole, Enilconazole, Miconazole, Chlorhexidine, Clotrimazole

What are the off-licence treatments for fungal dermatitis in reptiles?

Itraconazole, F10 product

What are the on-licence treatments for ringworm in horses?

Enilconazole

Test your knowledge on how antifungals work with this informative quiz. Learn about the chemical class of azoles and allylamines, and how they inhibit the synthesis of ergosterol in fungal cell membranes. Discover the key mechanisms behind antifungal action and deepen your understanding of these important medications.

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