Uncover the Mechanisms of Antifungal Action
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Questions and Answers

Which chemical class do most antifungal products belong to?

  • Allylamines
  • Azoles (correct)
  • Polyenes
  • Pyrimidine analogues

How do Azoles work as antifungals?

  • They bind to sterols in fungal cell membranes
  • They inhibit cytochrome P-450 dependent synthesis of ergosterol (correct)
  • They convert to an antimetabolite chemical
  • They inhibit an enzyme called squalene epoxidase

Which enzyme do allylamines inhibit in fungal cells?

  • Cytochrome P-450
  • Squalene epoxidase (correct)
  • 5-fluorocytosine
  • Ergosterol

Which sterol do polyenes specifically bind to in fungal cell membranes?

<p>Ergosterol (D)</p> Signup and view all the answers

What is the mechanism of action of pyrimidine analogues as antifungals?

<p>They convert to an antimetabolite chemical (A)</p> Signup and view all the answers

Which of the following is true about cellular toxins?

<p>They are specific to bacteria and yeasts (C)</p> Signup and view all the answers

What is the primary function of Vercom as a disinfectant?

<p>Oxidizing sulphur bonds in proteins and enzymes (D)</p> Signup and view all the answers

Which of the following is used to treat otitis externa in cats and dogs caused by Malassezia?

<p>Terbinafine (D)</p> Signup and view all the answers

What is a potential risk associated with using Posaconazole in cats?

<p>Neurological signs (D)</p> Signup and view all the answers

Which of the following is a licensed treatment for Malassezia skin infection in both cats and dogs?

<p>Miconazole (C)</p> Signup and view all the answers

Which drug is the drug of choice for treating dogs with ringworm?

<p>Itraconazole (A)</p> Signup and view all the answers

Which drug is off-licence in cats and is the drug of choice in cats with ringworm?

<p>Itraconazole (B)</p> Signup and view all the answers

Which drug is commonly used as a systemic treatment for ringworm in horses?

<p>Griseofulvin (C)</p> Signup and view all the answers

Which drug is licensed for the treatment of candidiasis and aspergillosis in non-food producing birds?

<p>Voriconazole (D)</p> Signup and view all the answers

Which drug is used as a skin rinse for ringworm in rabbits and small mammals?

<p>Enilconazole (C)</p> Signup and view all the answers

Which drug is commonly used as a systemic treatment for ringworm in horses?

<p>Griseofulvin (D)</p> Signup and view all the answers

Which drug is licensed for the treatment of candidiasis and aspergillosis in non-food producing birds?

<p>Voriconazole (B)</p> Signup and view all the answers

Which drug is off-licence in cats and is the drug of choice in cats with ringworm?

<p>Itraconazole (B)</p> Signup and view all the answers

Which of the following is used to treat otitis externa in cats and dogs caused by Malassezia?

<p>Chlorhexidine (A)</p> Signup and view all the answers

Which drug is used as a skin rinse for ringworm in rabbits and small mammals?

<p>Enilconazole (C)</p> Signup and view all the answers

Which chemical class of antifungal products inhibits cytochrome P-450 dependent synthesis of ergosterol in fungal cell membranes?

<p>Azoles (C)</p> Signup and view all the answers

What is the mechanism of action of allylamines as antifungals?

<p>Inhibit squalene epoxidase in fungal cells (A)</p> Signup and view all the answers

Which antifungal class specifically binds to ergosterol in fungal cell membranes?

<p>Polyenes (C)</p> Signup and view all the answers

What is the primary function of polyenes as antifungals?

<p>Cause physical change in fungal cell membrane (D)</p> Signup and view all the answers

Which of the following drugs is off-licence and primarily used for the treatment of Malassezia/Pseudomonas resistant infections in cats and dogs?

<p>Silver sulfadiazine (C)</p> Signup and view all the answers

What is the primary function of Chlorhexidine as an antiseptic?

<p>Binding to the skin and forming a protective layer (B)</p> Signup and view all the answers

Which drug is off-licence and associated with neurological and systemic signs in cats and dogs?

<p>Posaconazole (B)</p> Signup and view all the answers

Which drug is used as a topical treatment for otitis externa caused by Malassezia in cats and dogs?

<p>Miconazole (B)</p> Signup and view all the answers

Which drug is licensed for the treatment of Malassezia skin infection in both cats and dogs?

<p>Miconazole (C)</p> Signup and view all the answers

What are the off-licence treatments for ringworm in dogs and cats?

<p>Itraconazole, Ketoconazole, Enilconazole, Miconazole, Chlorhexidine</p> Signup and view all the answers

What are the off-licence treatments for systemic/deep mycoses, cryptococcosis, and urinary candidiasis in cats and dogs?

<p>Amphotericin B, Fluconazole, Flucytosine</p> Signup and view all the answers

What are the off-licence treatments for ringworm in rabbits and small mammals?

<p>Itraconazole, Enilconazole, Miconazole, Chlorhexidine, Clotrimazole</p> Signup and view all the answers

What are the off-licence treatments for fungal dermatitis in reptiles?

<p>Itraconazole, F10 product</p> Signup and view all the answers

What are the on-licence treatments for ringworm in horses?

<p>Enilconazole</p> Signup and view all the answers

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