Uncover the Mechanisms of Antifungal Action
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Questions and Answers

Which chemical class do most antifungal products belong to?

  • Allylamines
  • Azoles (correct)
  • Polyenes
  • Pyrimidine analogues

    • How do Azoles work as antifungals?

  • They bind to sterols in fungal cell membranes
  • They inhibit cytochrome P-450 dependent synthesis of ergosterol (correct)
  • They convert to an antimetabolite chemical
  • They inhibit an enzyme called squalene epoxidase

    • Which enzyme do allylamines inhibit in fungal cells?

  • Cytochrome P-450
  • Squalene epoxidase (correct)
  • 5-fluorocytosine
  • Ergosterol

    • Which sterol do polyenes specifically bind to in fungal cell membranes?

    <p>Ergosterol</p> Signup and view all the answers

    What is the mechanism of action of pyrimidine analogues as antifungals?

    <p>They convert to an antimetabolite chemical</p> Signup and view all the answers

    Which of the following is true about cellular toxins?

    <p>They are specific to bacteria and yeasts</p> Signup and view all the answers

    What is the primary function of Vercom as a disinfectant?

    <p>Oxidizing sulphur bonds in proteins and enzymes</p> Signup and view all the answers

    Which of the following is used to treat otitis externa in cats and dogs caused by Malassezia?

    <p>Terbinafine</p> Signup and view all the answers

    What is a potential risk associated with using Posaconazole in cats?

    <p>Neurological signs</p> Signup and view all the answers

    Which of the following is a licensed treatment for Malassezia skin infection in both cats and dogs?

    <p>Miconazole</p> Signup and view all the answers

    Which drug is the drug of choice for treating dogs with ringworm?

    <p>Itraconazole</p> Signup and view all the answers

    Which drug is off-licence in cats and is the drug of choice in cats with ringworm?

    <p>Itraconazole</p> Signup and view all the answers

    Which drug is commonly used as a systemic treatment for ringworm in horses?

    <p>Griseofulvin</p> Signup and view all the answers

    Which drug is licensed for the treatment of candidiasis and aspergillosis in non-food producing birds?

    <p>Voriconazole</p> Signup and view all the answers

    Which drug is used as a skin rinse for ringworm in rabbits and small mammals?

    <p>Enilconazole</p> Signup and view all the answers

    Which drug is commonly used as a systemic treatment for ringworm in horses?

    <p>Griseofulvin</p> Signup and view all the answers

    Which drug is licensed for the treatment of candidiasis and aspergillosis in non-food producing birds?

    <p>Voriconazole</p> Signup and view all the answers

    Which drug is off-licence in cats and is the drug of choice in cats with ringworm?

    <p>Itraconazole</p> Signup and view all the answers

    Which of the following is used to treat otitis externa in cats and dogs caused by Malassezia?

    <p>Chlorhexidine</p> Signup and view all the answers

    Which drug is used as a skin rinse for ringworm in rabbits and small mammals?

    <p>Enilconazole</p> Signup and view all the answers

    Which chemical class of antifungal products inhibits cytochrome P-450 dependent synthesis of ergosterol in fungal cell membranes?

    <p>Azoles</p> Signup and view all the answers

    What is the mechanism of action of allylamines as antifungals?

    <p>Inhibit squalene epoxidase in fungal cells</p> Signup and view all the answers

    Which antifungal class specifically binds to ergosterol in fungal cell membranes?

    <p>Polyenes</p> Signup and view all the answers

    What is the primary function of polyenes as antifungals?

    <p>Cause physical change in fungal cell membrane</p> Signup and view all the answers

    Which of the following drugs is off-licence and primarily used for the treatment of Malassezia/Pseudomonas resistant infections in cats and dogs?

    <p>Silver sulfadiazine</p> Signup and view all the answers

    What is the primary function of Chlorhexidine as an antiseptic?

    <p>Binding to the skin and forming a protective layer</p> Signup and view all the answers

    Which drug is off-licence and associated with neurological and systemic signs in cats and dogs?

    <p>Posaconazole</p> Signup and view all the answers

    Which drug is used as a topical treatment for otitis externa caused by Malassezia in cats and dogs?

    <p>Miconazole</p> Signup and view all the answers

    Which drug is licensed for the treatment of Malassezia skin infection in both cats and dogs?

    <p>Miconazole</p> Signup and view all the answers

    What are the off-licence treatments for ringworm in dogs and cats?

    <p>Itraconazole, Ketoconazole, Enilconazole, Miconazole, Chlorhexidine</p> Signup and view all the answers

    What are the off-licence treatments for systemic/deep mycoses, cryptococcosis, and urinary candidiasis in cats and dogs?

    <p>Amphotericin B, Fluconazole, Flucytosine</p> Signup and view all the answers

    What are the off-licence treatments for ringworm in rabbits and small mammals?

    <p>Itraconazole, Enilconazole, Miconazole, Chlorhexidine, Clotrimazole</p> Signup and view all the answers

    What are the off-licence treatments for fungal dermatitis in reptiles?

    <p>Itraconazole, F10 product</p> Signup and view all the answers

    What are the on-licence treatments for ringworm in horses?

    <p>Enilconazole</p> Signup and view all the answers

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