Uncover the Mechanisms of Antifungal Action

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Which chemical class do most antifungal products belong to?

Allylamines

Azoles (correct)

Polyenes

Pyrimidine analogues

How do Azoles work as antifungals?

They bind to sterols in fungal cell membranes

They inhibit cytochrome P-450 dependent synthesis of ergosterol (correct)

They convert to an antimetabolite chemical

They inhibit an enzyme called squalene epoxidase

Which enzyme do allylamines inhibit in fungal cells?

Cytochrome P-450

Squalene epoxidase (correct)

5-fluorocytosine

Ergosterol

Which sterol do polyenes specifically bind to in fungal cell membranes?

Ergosterol Signup and view all the answers

What is the mechanism of action of pyrimidine analogues as antifungals?

They convert to an antimetabolite chemical Signup and view all the answers

Which of the following is true about cellular toxins?

They are specific to bacteria and yeasts Signup and view all the answers

What is the primary function of Vercom as a disinfectant?

Oxidizing sulphur bonds in proteins and enzymes Signup and view all the answers

Which of the following is used to treat otitis externa in cats and dogs caused by Malassezia?

Terbinafine Signup and view all the answers

What is a potential risk associated with using Posaconazole in cats?

Neurological signs Signup and view all the answers

Which of the following is a licensed treatment for Malassezia skin infection in both cats and dogs?

Miconazole Signup and view all the answers

Which drug is the drug of choice for treating dogs with ringworm?

Itraconazole Signup and view all the answers

Which drug is off-licence in cats and is the drug of choice in cats with ringworm?

Itraconazole Signup and view all the answers

Which drug is commonly used as a systemic treatment for ringworm in horses?

Griseofulvin Signup and view all the answers

Which drug is licensed for the treatment of candidiasis and aspergillosis in non-food producing birds?

Voriconazole Signup and view all the answers

Which drug is used as a skin rinse for ringworm in rabbits and small mammals?

Enilconazole Signup and view all the answers

Which drug is commonly used as a systemic treatment for ringworm in horses?

Griseofulvin Signup and view all the answers

Which drug is licensed for the treatment of candidiasis and aspergillosis in non-food producing birds?

Voriconazole Signup and view all the answers

Which drug is off-licence in cats and is the drug of choice in cats with ringworm?

Itraconazole Signup and view all the answers

Which of the following is used to treat otitis externa in cats and dogs caused by Malassezia?

Chlorhexidine Signup and view all the answers

Which drug is used as a skin rinse for ringworm in rabbits and small mammals?

Enilconazole Signup and view all the answers

Which chemical class of antifungal products inhibits cytochrome P-450 dependent synthesis of ergosterol in fungal cell membranes?

Azoles Signup and view all the answers

What is the mechanism of action of allylamines as antifungals?

Inhibit squalene epoxidase in fungal cells Signup and view all the answers

Which antifungal class specifically binds to ergosterol in fungal cell membranes?

Polyenes Signup and view all the answers

What is the primary function of polyenes as antifungals?

Cause physical change in fungal cell membrane Signup and view all the answers

Which of the following drugs is off-licence and primarily used for the treatment of Malassezia/Pseudomonas resistant infections in cats and dogs?

Silver sulfadiazine Signup and view all the answers

What is the primary function of Chlorhexidine as an antiseptic?

Binding to the skin and forming a protective layer Signup and view all the answers

Which drug is off-licence and associated with neurological and systemic signs in cats and dogs?

Posaconazole Signup and view all the answers

Which drug is used as a topical treatment for otitis externa caused by Malassezia in cats and dogs?

Miconazole Signup and view all the answers

Which drug is licensed for the treatment of Malassezia skin infection in both cats and dogs?

Miconazole Signup and view all the answers

What are the off-licence treatments for ringworm in dogs and cats?

Itraconazole, Ketoconazole, Enilconazole, Miconazole, Chlorhexidine Signup and view all the answers

What are the off-licence treatments for systemic/deep mycoses, cryptococcosis, and urinary candidiasis in cats and dogs?

Amphotericin B, Fluconazole, Flucytosine Signup and view all the answers

What are the off-licence treatments for ringworm in rabbits and small mammals?

Itraconazole, Enilconazole, Miconazole, Chlorhexidine, Clotrimazole Signup and view all the answers

What are the off-licence treatments for fungal dermatitis in reptiles?

Itraconazole, F10 product Signup and view all the answers

What are the on-licence treatments for ringworm in horses?

Enilconazole Signup and view all the answers

Uncover the Mechanisms of Antifungal Action

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Questions and Answers

Which chemical class do most antifungal products belong to?

How do Azoles work as antifungals?

Which enzyme do allylamines inhibit in fungal cells?

Which sterol do polyenes specifically bind to in fungal cell membranes?

What is the mechanism of action of pyrimidine analogues as antifungals?

Which of the following is true about cellular toxins?

What is the primary function of Vercom as a disinfectant?

Which of the following is used to treat otitis externa in cats and dogs caused by Malassezia?

What is a potential risk associated with using Posaconazole in cats?

Which of the following is a licensed treatment for Malassezia skin infection in both cats and dogs?

Which drug is the drug of choice for treating dogs with ringworm?

Which drug is off-licence in cats and is the drug of choice in cats with ringworm?

Which drug is commonly used as a systemic treatment for ringworm in horses?

Which drug is licensed for the treatment of candidiasis and aspergillosis in non-food producing birds?

Which drug is used as a skin rinse for ringworm in rabbits and small mammals?

Which drug is commonly used as a systemic treatment for ringworm in horses?

Which drug is licensed for the treatment of candidiasis and aspergillosis in non-food producing birds?

Which drug is off-licence in cats and is the drug of choice in cats with ringworm?

Which of the following is used to treat otitis externa in cats and dogs caused by Malassezia?

Which drug is used as a skin rinse for ringworm in rabbits and small mammals?

Which chemical class of antifungal products inhibits cytochrome P-450 dependent synthesis of ergosterol in fungal cell membranes?

What is the mechanism of action of allylamines as antifungals?

Which antifungal class specifically binds to ergosterol in fungal cell membranes?

What is the primary function of polyenes as antifungals?

Which of the following drugs is off-licence and primarily used for the treatment of Malassezia/Pseudomonas resistant infections in cats and dogs?

What is the primary function of Chlorhexidine as an antiseptic?

Which drug is off-licence and associated with neurological and systemic signs in cats and dogs?

Which drug is used as a topical treatment for otitis externa caused by Malassezia in cats and dogs?

Which drug is licensed for the treatment of Malassezia skin infection in both cats and dogs?

What are the off-licence treatments for ringworm in dogs and cats?

What are the off-licence treatments for systemic/deep mycoses, cryptococcosis, and urinary candidiasis in cats and dogs?

What are the off-licence treatments for ringworm in rabbits and small mammals?

What are the off-licence treatments for fungal dermatitis in reptiles?

What are the on-licence treatments for ringworm in horses?

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