Tuberculosis: Causes and Immune Response Quiz
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Questions and Answers

What organism causes tuberculosis and what is its distinguishing characteristic?

Tuberculosis is caused by the organism Mycobacterium tuberculosis, which is a slow-growing, slender, rod-shaped acid-fast bacillus with a waxy outer capsule.

Describe the role of the immune system in the development of a granuloma during tuberculosis infection.

In response to TB infection, alveolar macrophages create a granuloma that contains the bacteria, surrounded by collagen, fibroblasts, and lymphocytes, isolating the pathogen.

What are the primary modes of transmission for tuberculosis?

Tuberculosis spreads predominantly through aerosolization from person to person, typically requiring close, frequent, or prolonged exposure to an infected individual.

What distinguishes latent tuberculosis infection from active tuberculosis disease?

<p>Latent tuberculosis infection occurs when a person is infected but does not exhibit symptoms and cannot spread the disease, whereas active tuberculosis involves symptomatic disease that can be transmitted.</p> Signup and view all the answers

Identify two factors that contribute to the resurgence of tuberculosis cases.

<p>High rates of tuberculosis in individuals with HIV infection and increased immunosuppression among certain populations contribute to the resurgence of tuberculosis.</p> Signup and view all the answers

What diagnostic test results might indicate the presence of TB?

<p>Results from the tuberculin skin test, interferon-gamma release assay, or sputum culture can indicate the presence of TB.</p> Signup and view all the answers

What are some common nursing diagnoses for patients with TB?

<p>Ineffective airway clearance and alteration in gas exchange related to necrosis of lung tissue are common nursing diagnoses.</p> Signup and view all the answers

What are the goals of planning care for a patient with TB?

<p>Goals include achieving functional pulmonary function, compliance with the therapeutic regimen, and preventing disease recurrence.</p> Signup and view all the answers

What precautions should be taken with patients suspected of having TB during acute intervention?

<p>Patients suspected of having TB should be placed on airborne isolation precautions.</p> Signup and view all the answers

What essential teaching should be given to patients on airborne isolation?

<p>Patients should be taught the importance of wearing masks and following isolation protocols to prevent airborne transmission.</p> Signup and view all the answers

What does multidrug-resistant tuberculosis (MDR TB) indicate about a TB infection?

<p>It indicates resistance to the first line drugs used to treat tuberculosis.</p> Signup and view all the answers

List two populations that are disproportionately affected by multidrug-resistant strains of TB.

<p>The poor and underserved populations, as well as minorities.</p> Signup and view all the answers

What is the significance of a chest X-ray in diagnosing tuberculosis?

<p>It helps evaluate pulmonary tuberculosis findings and can show dense lesions and cavity formations.</p> Signup and view all the answers

What are common manifestations of tuberculosis that should raise suspicion for the disease?

<p>Common manifestations include fatigue, weight loss, night sweats, and a persistent cough.</p> Signup and view all the answers

What is the purpose of the intradermal PPD (Mantoux) test?

<p>It is used to determine exposure and infection with tuberculosis.</p> Signup and view all the answers

Name one complication of tuberculosis that can occur beyond pulmonary infections.

<p>Miliary tuberculosis is one possible complication.</p> Signup and view all the answers

What factors increase the risk of developing multidrug-resistant TB?

<p>Close contact with active TB patients, immunocompromised status, and inadequate healthcare resources.</p> Signup and view all the answers

Explain the role of Interferon-gamma release assays (IGRAs) in TB diagnosis.

<p>IGRAs indicate TB infection but do not differentiate between active and latent TB.</p> Signup and view all the answers

What are two key behaviors patients should be taught to promote isolation and prevent the spread of infection?

<p>Patients should be taught to cough or sneeze into a tissue and practice careful hand-washing after handling sputum or soiled tissues.</p> Signup and view all the answers

How can healthcare providers promote airway clearance in patients dealing with respiratory conditions?

<p>Healthcare providers can promote airway clearance by administering humidified oxygen.</p> Signup and view all the answers

What should patients understand about the treatment regimen for tuberculosis during and after their acute care?

<p>Patients should understand the importance of medication adherence and the potential side effects of therapy.</p> Signup and view all the answers

What role do community clinics play in the management of tuberculosis in an ambulatory care setting?

<p>Community clinics provide low-cost treatment options and essential follow-up care for patients with tuberculosis.</p> Signup and view all the answers

Why is it important for individuals living with a person infected with tuberculosis to receive skin testing?

<p>Skin testing is important to identify latent TB infection early, allowing timely intervention and treatment.</p> Signup and view all the answers

What should patients taking Rifampin report immediately to their healthcare provider?

<p>Patients should report yellowing of the skin, pain or swelling of joints, loss of appetite, or malaise.</p> Signup and view all the answers

How can Pyrazinamide affect a patient's daily hydration?

<p>Patients should drink a glass of water with each dose and increase fluid intake throughout the day to prevent dehydration.</p> Signup and view all the answers

What baselines should be established before administering Ethambutol?

<p>Baseline visual acuity tests and color discrimination ability should be determined.</p> Signup and view all the answers

What is the recommended fluid intake for patients on Streptomycin Sulfate?

<p>Patients should consume at least 2-3 liters of fluid daily.</p> Signup and view all the answers

Identify two clinical manifestations of active TB disease.

<p>Two manifestations are unexplained weight loss and low-grade fevers.</p> Signup and view all the answers

What is a significant precaution patients must take when taking any of the TB medications discussed?

<p>Patients must avoid alcohol while on these medications.</p> Signup and view all the answers

How does latent TB infection differ from active TB disease in terms of symptoms?

<p>Patients with latent TB infection are symptom-free, while those with active TB may experience fatigue and cough.</p> Signup and view all the answers

What is one potential effect of Ethambutol that requires immediate reporting?

<p>Changes in vision should be reported immediately.</p> Signup and view all the answers

What is the classification of tuberculosis for a person with a positive PPD but no active disease?

<p>Class 2: Latent infection; no disease.</p> Signup and view all the answers

What baseline data is essential before initiating treatment for tuberculosis?

<p>Liver function tests, renal function studies, vision examination, and audiometric testing.</p> Signup and view all the answers

What is the goal of therapy in the treatment of tuberculosis?

<p>To make the disease noncommunicable, reduce symptoms, and effect a cure in the shortest time.</p> Signup and view all the answers

Who is the Bacillus Calmette-Guerin (BCG) vaccine recommended for in the United States?

<p>Infants, children, and healthcare workers exposed to untreated or ineffectively treated active TB patients.</p> Signup and view all the answers

What is the recommended duration for prophylactic treatment of tuberculosis?

<p>6 to 12 months with a single drug.</p> Signup and view all the answers

Which four first-line medications are included in the initial phase regimen for TB treatment?

<p>Isoniazid (INH), Rifampin (RIF), Pyrazinamide (PZA), Ethambutol (EMB).</p> Signup and view all the answers

What action should be taken if cultures remain positive after 2-3 months of TB therapy?

<p>Consider drug resistance and add 2-3 other medications to the regimen.</p> Signup and view all the answers

What dietary restriction should patients on Isoniazid avoid to prevent adverse reactions?

<p>Avoid foods containing tyramine and histamine such as aged cheese, red wine, and soy sauce.</p> Signup and view all the answers

What is Directly Observed Therapy (DOT) in the context of tuberculosis treatment?

<p>A strategy to ensure adherence by having a healthcare provider observe the patient taking their medications.</p> Signup and view all the answers

What type of monitoring is necessary for patients taking Isoniazid?

<p>Monitor for hepatotoxicity and neurotoxicity, and provide Vitamin B6 to prevent neurotoxicity.</p> Signup and view all the answers

Study Notes

Tuberculosis (TB) Overview

  • Tuberculosis (TB) is caused by Mycobacterium tuberculosis.
  • It's a slow-growing, rod-shaped, acid-fast organism with a waxy outer capsule.
  • TB spreads via aerosolization.

Tuberculosis Pathophysiology

  • Transmission requires close, frequent, or prolonged exposure.
  • Bacteria lodge in alveoli of the small distal airways.
  • Local inflammatory response leads to granuloma formation.
  • Macrophages contain bacteria, surrounded by collagen, fibroblasts, and lymphocytes.
  • The lesion center becomes necrotic, forming a granular mass.
  • Cavities can form, calcify, and be seen on chest x-rays.

Latent Tuberculosis Infection

  • If infected but not symptomatic, TB is not spread.
  • Reactivation can occur in those with chronic diseases or immunosuppression.

Active Tuberculosis Disease

  • An inadequate initial immune response allows the organism to multiply.
  • This leads to primary active TB disease or primary tuberculosis infection.
  • Bacteria can spread.
  • Severe progression can lead to complications such as: Miliary TB, Pleural Effusion and Empyema, Genitourinary Tuberculosis, Tuberculosis Meningitis, Skeletal Tuberculosis.

Tuberculosis Resurgence

  • High rates of TB occur in individuals with HIV infections.
  • Multidrug-resistant (MDR) strains are emerging.
  • The disease disproportionately affects the poor, underserved, and minority populations.

Drug Resistance

  • Multidrug-resistance (MDR TB) is resistance to first-line TB drugs.
  • Pre-extensively drug-resistant TB (pre-XDR TB) is a precursor to extensively drug-resistant TB (XDR TB).
  • XDR TB is resistance to first-line TB drugs, at least one second-line TB drug, and at least one drug in the quinolone antibiotic sub-class.

Risk Factors for TB

  • Close contact with an active TB patient.
  • Immunocompromised individuals.
  • Substance abuse.
  • Inadequate health care resources.
  • Pre-existing medical conditions.
  • Immigration from countries with high TB prevalence.
  • Living in overcrowded or substandard housing.
  • Healthcare workers performing high-risk activities.

Manifestations of TB

  • Fatigue
  • Weight loss
  • Loss of appetite
  • Low-grade fever
  • Night sweats
  • Cough

Diagnostic Studies

  • Tuberculin Skin Test (Mantoux): Uses PPD, read after 48-72 hours.
  • Chest X-Ray: Evaluates pulmonary TB; dense lesions, cavity formation.
  • Acid-fast Bacillus smear: Determines the presence of tubercle bacilli but not specific to TB.
  • Interferon-gamma release assays (IGRAs): Indicate TB infection and do not distinguish active vs latent TB. QuantiFERON-TB Gold and T-SPOT TB are examples.
  • Sputum culture: Definitive diagnosis of TB by identifying M. tuberculosis.
  • Other tests are mentioned including acid fast bacillus smear, PPD, chest x-ray, sputum culture, IGRAs, and other similar assessments.

Tuberculosis Treatment and Collaborative Care

  • Goals: Make disease noncommunicable, reduce symptoms, hasten recovery.
  • Initial treatment phase: Typically 2 months of multiple medications (e.g., Isoniazid, Rifampin).
  • Continuation phase: Four+ months of Isoniazid and Rifampin.
  • Multi-drug resistant TB may require different/additional regimen.
  • Follow-up care: Negative cultures within 2-3 months signify effective treatment; longer time or positive cultures may suggest resistance necessitating other drugs.
  • Directly Observed Therapy (DOT): Critical for adherent therapy.
  • Other medications include: Capreomycin, ethionamide, para-aminosalicylate sodium, cycloserine. Specific monitoring and precautions associated with each.
  • Baseline measurements of liver and renal function along with visual and auditory tests may be necessary.
  • Additional measures include Airborne isolation, humidified oxygen, and supportive care to address symptoms and provide effective treatment.

Tuberculosis Classification

  • Class 0: No exposure, not infected.
  • Class 1: Exposure, but no evidence of infection.
  • Class 2: Latent infection, no active disease with a positive PPD or IGRA.
  • Class 3: Disease, clinically active TB.
  • Class 4: Previous TB disease, not currently active.
  • Class 5: Suspected TB, pending diagnosis.

Nursing Assessment

  • Patient's exposure to TB, country of origin.
  • Previous TB test results and BCG vaccination status.
  • Clinical manifestations such as temperature, sputum, breath sounds, oxygen saturation.

Nursing Implementation

  • Health Promotion: Selective screening in high-risk groups, evaluate exposures, skin testing for exposure, chest x-rays for positive skin tests.
  • Acute Interventions: Airborne precautions, oxygen administration, appropriate drug regimen, immediate medical workup, and education on specific isolation techniques.
  • Ambulatory/Home Care: Educate about TB, medications, side effects, sputum collection, avoid inhalants, support and follow-up. Community resources and follow-up care.

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Description

Test your knowledge on tuberculosis, including its causative organism, the immune system's role in granuloma formation, and transmission methods. Understand the difference between latent and active TB, and identify factors contributing to the resurgence of cases. This quiz covers essential aspects of tuberculosis for health education.

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