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What organism causes tuberculosis and what is its distinguishing characteristic?
What organism causes tuberculosis and what is its distinguishing characteristic?
Tuberculosis is caused by the organism Mycobacterium tuberculosis, which is a slow-growing, slender, rod-shaped acid-fast bacillus with a waxy outer capsule.
Describe the role of the immune system in the development of a granuloma during tuberculosis infection.
Describe the role of the immune system in the development of a granuloma during tuberculosis infection.
In response to TB infection, alveolar macrophages create a granuloma that contains the bacteria, surrounded by collagen, fibroblasts, and lymphocytes, isolating the pathogen.
What are the primary modes of transmission for tuberculosis?
What are the primary modes of transmission for tuberculosis?
Tuberculosis spreads predominantly through aerosolization from person to person, typically requiring close, frequent, or prolonged exposure to an infected individual.
What distinguishes latent tuberculosis infection from active tuberculosis disease?
What distinguishes latent tuberculosis infection from active tuberculosis disease?
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Identify two factors that contribute to the resurgence of tuberculosis cases.
Identify two factors that contribute to the resurgence of tuberculosis cases.
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What diagnostic test results might indicate the presence of TB?
What diagnostic test results might indicate the presence of TB?
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What are some common nursing diagnoses for patients with TB?
What are some common nursing diagnoses for patients with TB?
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What are the goals of planning care for a patient with TB?
What are the goals of planning care for a patient with TB?
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What precautions should be taken with patients suspected of having TB during acute intervention?
What precautions should be taken with patients suspected of having TB during acute intervention?
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What essential teaching should be given to patients on airborne isolation?
What essential teaching should be given to patients on airborne isolation?
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What does multidrug-resistant tuberculosis (MDR TB) indicate about a TB infection?
What does multidrug-resistant tuberculosis (MDR TB) indicate about a TB infection?
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List two populations that are disproportionately affected by multidrug-resistant strains of TB.
List two populations that are disproportionately affected by multidrug-resistant strains of TB.
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What is the significance of a chest X-ray in diagnosing tuberculosis?
What is the significance of a chest X-ray in diagnosing tuberculosis?
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What are common manifestations of tuberculosis that should raise suspicion for the disease?
What are common manifestations of tuberculosis that should raise suspicion for the disease?
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What is the purpose of the intradermal PPD (Mantoux) test?
What is the purpose of the intradermal PPD (Mantoux) test?
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Name one complication of tuberculosis that can occur beyond pulmonary infections.
Name one complication of tuberculosis that can occur beyond pulmonary infections.
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What factors increase the risk of developing multidrug-resistant TB?
What factors increase the risk of developing multidrug-resistant TB?
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Explain the role of Interferon-gamma release assays (IGRAs) in TB diagnosis.
Explain the role of Interferon-gamma release assays (IGRAs) in TB diagnosis.
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What are two key behaviors patients should be taught to promote isolation and prevent the spread of infection?
What are two key behaviors patients should be taught to promote isolation and prevent the spread of infection?
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How can healthcare providers promote airway clearance in patients dealing with respiratory conditions?
How can healthcare providers promote airway clearance in patients dealing with respiratory conditions?
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What should patients understand about the treatment regimen for tuberculosis during and after their acute care?
What should patients understand about the treatment regimen for tuberculosis during and after their acute care?
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What role do community clinics play in the management of tuberculosis in an ambulatory care setting?
What role do community clinics play in the management of tuberculosis in an ambulatory care setting?
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Why is it important for individuals living with a person infected with tuberculosis to receive skin testing?
Why is it important for individuals living with a person infected with tuberculosis to receive skin testing?
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What should patients taking Rifampin report immediately to their healthcare provider?
What should patients taking Rifampin report immediately to their healthcare provider?
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How can Pyrazinamide affect a patient's daily hydration?
How can Pyrazinamide affect a patient's daily hydration?
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What baselines should be established before administering Ethambutol?
What baselines should be established before administering Ethambutol?
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What is the recommended fluid intake for patients on Streptomycin Sulfate?
What is the recommended fluid intake for patients on Streptomycin Sulfate?
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Identify two clinical manifestations of active TB disease.
Identify two clinical manifestations of active TB disease.
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What is a significant precaution patients must take when taking any of the TB medications discussed?
What is a significant precaution patients must take when taking any of the TB medications discussed?
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How does latent TB infection differ from active TB disease in terms of symptoms?
How does latent TB infection differ from active TB disease in terms of symptoms?
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What is one potential effect of Ethambutol that requires immediate reporting?
What is one potential effect of Ethambutol that requires immediate reporting?
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What is the classification of tuberculosis for a person with a positive PPD but no active disease?
What is the classification of tuberculosis for a person with a positive PPD but no active disease?
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What baseline data is essential before initiating treatment for tuberculosis?
What baseline data is essential before initiating treatment for tuberculosis?
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What is the goal of therapy in the treatment of tuberculosis?
What is the goal of therapy in the treatment of tuberculosis?
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Who is the Bacillus Calmette-Guerin (BCG) vaccine recommended for in the United States?
Who is the Bacillus Calmette-Guerin (BCG) vaccine recommended for in the United States?
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What is the recommended duration for prophylactic treatment of tuberculosis?
What is the recommended duration for prophylactic treatment of tuberculosis?
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Which four first-line medications are included in the initial phase regimen for TB treatment?
Which four first-line medications are included in the initial phase regimen for TB treatment?
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What action should be taken if cultures remain positive after 2-3 months of TB therapy?
What action should be taken if cultures remain positive after 2-3 months of TB therapy?
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What dietary restriction should patients on Isoniazid avoid to prevent adverse reactions?
What dietary restriction should patients on Isoniazid avoid to prevent adverse reactions?
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What is Directly Observed Therapy (DOT) in the context of tuberculosis treatment?
What is Directly Observed Therapy (DOT) in the context of tuberculosis treatment?
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What type of monitoring is necessary for patients taking Isoniazid?
What type of monitoring is necessary for patients taking Isoniazid?
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Study Notes
Tuberculosis (TB) Overview
- Tuberculosis (TB) is caused by Mycobacterium tuberculosis.
- It's a slow-growing, rod-shaped, acid-fast organism with a waxy outer capsule.
- TB spreads via aerosolization.
Tuberculosis Pathophysiology
- Transmission requires close, frequent, or prolonged exposure.
- Bacteria lodge in alveoli of the small distal airways.
- Local inflammatory response leads to granuloma formation.
- Macrophages contain bacteria, surrounded by collagen, fibroblasts, and lymphocytes.
- The lesion center becomes necrotic, forming a granular mass.
- Cavities can form, calcify, and be seen on chest x-rays.
Latent Tuberculosis Infection
- If infected but not symptomatic, TB is not spread.
- Reactivation can occur in those with chronic diseases or immunosuppression.
Active Tuberculosis Disease
- An inadequate initial immune response allows the organism to multiply.
- This leads to primary active TB disease or primary tuberculosis infection.
- Bacteria can spread.
- Severe progression can lead to complications such as: Miliary TB, Pleural Effusion and Empyema, Genitourinary Tuberculosis, Tuberculosis Meningitis, Skeletal Tuberculosis.
Tuberculosis Resurgence
- High rates of TB occur in individuals with HIV infections.
- Multidrug-resistant (MDR) strains are emerging.
- The disease disproportionately affects the poor, underserved, and minority populations.
Drug Resistance
- Multidrug-resistance (MDR TB) is resistance to first-line TB drugs.
- Pre-extensively drug-resistant TB (pre-XDR TB) is a precursor to extensively drug-resistant TB (XDR TB).
- XDR TB is resistance to first-line TB drugs, at least one second-line TB drug, and at least one drug in the quinolone antibiotic sub-class.
Risk Factors for TB
- Close contact with an active TB patient.
- Immunocompromised individuals.
- Substance abuse.
- Inadequate health care resources.
- Pre-existing medical conditions.
- Immigration from countries with high TB prevalence.
- Living in overcrowded or substandard housing.
- Healthcare workers performing high-risk activities.
Manifestations of TB
- Fatigue
- Weight loss
- Loss of appetite
- Low-grade fever
- Night sweats
- Cough
Diagnostic Studies
- Tuberculin Skin Test (Mantoux): Uses PPD, read after 48-72 hours.
- Chest X-Ray: Evaluates pulmonary TB; dense lesions, cavity formation.
- Acid-fast Bacillus smear: Determines the presence of tubercle bacilli but not specific to TB.
- Interferon-gamma release assays (IGRAs): Indicate TB infection and do not distinguish active vs latent TB. QuantiFERON-TB Gold and T-SPOT TB are examples.
- Sputum culture: Definitive diagnosis of TB by identifying M. tuberculosis.
- Other tests are mentioned including acid fast bacillus smear, PPD, chest x-ray, sputum culture, IGRAs, and other similar assessments.
Tuberculosis Treatment and Collaborative Care
- Goals: Make disease noncommunicable, reduce symptoms, hasten recovery.
- Initial treatment phase: Typically 2 months of multiple medications (e.g., Isoniazid, Rifampin).
- Continuation phase: Four+ months of Isoniazid and Rifampin.
- Multi-drug resistant TB may require different/additional regimen.
- Follow-up care: Negative cultures within 2-3 months signify effective treatment; longer time or positive cultures may suggest resistance necessitating other drugs.
- Directly Observed Therapy (DOT): Critical for adherent therapy.
- Other medications include: Capreomycin, ethionamide, para-aminosalicylate sodium, cycloserine. Specific monitoring and precautions associated with each.
- Baseline measurements of liver and renal function along with visual and auditory tests may be necessary.
- Additional measures include Airborne isolation, humidified oxygen, and supportive care to address symptoms and provide effective treatment.
Tuberculosis Classification
- Class 0: No exposure, not infected.
- Class 1: Exposure, but no evidence of infection.
- Class 2: Latent infection, no active disease with a positive PPD or IGRA.
- Class 3: Disease, clinically active TB.
- Class 4: Previous TB disease, not currently active.
- Class 5: Suspected TB, pending diagnosis.
Nursing Assessment
- Patient's exposure to TB, country of origin.
- Previous TB test results and BCG vaccination status.
- Clinical manifestations such as temperature, sputum, breath sounds, oxygen saturation.
Nursing Implementation
- Health Promotion: Selective screening in high-risk groups, evaluate exposures, skin testing for exposure, chest x-rays for positive skin tests.
- Acute Interventions: Airborne precautions, oxygen administration, appropriate drug regimen, immediate medical workup, and education on specific isolation techniques.
- Ambulatory/Home Care: Educate about TB, medications, side effects, sputum collection, avoid inhalants, support and follow-up. Community resources and follow-up care.
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Description
Test your knowledge on tuberculosis, including its causative organism, the immune system's role in granuloma formation, and transmission methods. Understand the difference between latent and active TB, and identify factors contributing to the resurgence of cases. This quiz covers essential aspects of tuberculosis for health education.