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What are the brand names for Triamterene with hydrochlorothiazide?
What is the therapeutic class of Triamterene with hydrochlorothiazide?
Potassium sparing/thiazide diuretic combination
What are the dosage forms of Triamterene with hydrochlorothiazide?
What are the indications for using Triamterene with hydrochlorothiazide?
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What is the efficacy of Triamterene with hydrochlorothiazide?
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The mechanism of action (MOA) of Triamterene involves active sodium exchange for ______.
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What is a common patient counseling point when using Triamterene with hydrochlorothiazide?
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Match the following adverse effects (AE) with their categories:
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What are the signs of potential toxicity associated with Triamterene with hydrochlorothiazide?
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Which medications can interact with Triamterene with hydrochlorothiazide?
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What are contraindications for using Triamterene with hydrochlorothiazide?
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What Black Box Warning (BBW) applies to Triamterene with hydrochlorothiazide?
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What is the usual dosing for Triamterene with hydrochlorothiazide?
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What organ system is important for the pharmacology of Triamterene with hydrochlorothiazide?
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Study Notes
Brand/Generic Names
- Dyazide and Maxzide are the brand names for triamterene with hydrochlorothiazide.
Therapeutic Class
- Classified as a potassium-sparing and thiazide diuretic combination.
Dosage Forms
- Available in tablet and capsule forms.
Indications for Use
- Primarily indicated for the treatment of edema and hypertension.
Efficacy
- Effective in lowering blood pressure and reducing edema.
Mechanism of Action (MOA)
- Triamterene inhibits sodium exchange for potassium and hydrogen in the distal tubular lumen, leading to mild diuresis independent of aldosterone.
- Hydrochlorothiazide enhances sodium and chloride excretion by blocking their reabsorption in the nephron’s cortical diluting segment.
Patient Counseling Tips
- Patients may experience dizziness; advise gradual position changes to mitigate this.
- Instruct to avoid high potassium foods, potassium supplements, or potassium-based salt substitutes.
- Recommend caution with NSAIDs use.
- May cause photosensitivity; sunscreen is advised.
- Caution is necessary for patients with a sulfonamide allergy.
Adverse Events (AEs)
- Common side effects include hypotension, dizziness, and headache.
- Serious adverse effects may include cardiac arrhythmias, hepatitis, hyperkalemia, gout, and pancreatitis.
Toxicity Signs
- Monitor for altered serum and urine electrolytes (calcium, magnesium, potassium, sodium).
- Decreased renal function indicated by increased serum creatinine or reduced urine output.
- High serum uric acid or blood glucose levels are concerns.
- Seek immediate medical advice for skin rash, jaundice, decreased urine output, or gout symptoms.
Drug Interactions
- Caution advised with concurrent use of aliskiren, ACE inhibitors (ACEIs), ARBs, and other potassium-sparing diuretics.
- Be wary of interactions with potassium supplements, calcium supplements, antidiabetic agents, and NSAIDs.
Contraindications
- Contraindicated in patients with hypersensitivity to hydrochlorothiazide, sulfonamides, or triamterene.
- Avoid in patients taking potassium supplements, potassium-based salt substitutes, or other potassium-sparing diuretics.
- Not suitable for patients with anuria, acute or chronic renal insufficiency, or hyperkalemia.
Black Box Warning (BBW)
- Warning for the risk of hyperkalemia.
Standard Dosing
- Typical doses include 37.5 mg/25 mg and 75 mg/50 mg daily.
Pharmacology
- Requires functional renal capabilities for effectiveness.
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Description
This quiz provides flashcards on the drug Triamterene with Hydrochlorothiazide, covering essential concepts such as brand names, therapeutic class, dosage forms, indications, efficacy, and mechanism of action. Prepare yourself for exams or enhance your understanding of this medication through these key points.
