Questions and Answers
Explain the role of platelets in the development of atherosclerosis.
Platelets release inflammatory mediators and platelet-derived growth factor (PDGF), which stimulate the migration and proliferation of smooth muscle cells (SMCs) in the arterial wall. This contributes to the formation of a fibrous plaque in the intima.
What is the role of platelets in the development of atherosclerosis?
Platelets release inflammatory mediators and PDGF, which stimulate the migration and proliferation of SMCs, leading to the formation of fatty streaks.
What is the significance of macrophages and SMCs transforming into foam cells in the development of atherosclerosis?
Macrophages and SMCs ingest cholesterol and transform into foam cells, which accumulate to form fatty streaks in the arterial wall. These fatty streaks are the earliest visible lesion of atherosclerosis and can progress to form a fibrous plaque, leading to arterial stenosis.
How do foam cells contribute to the development of atherosclerotic plaques?
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How does plaque rupture contribute to the complications of atherosclerosis?
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What are the potential consequences of plaque rupture in atherosclerosis?
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