Podcast
Questions and Answers
What are some examples of the therapeutic uses for thyroid hormone replacement?
What are some examples of the therapeutic uses for thyroid hormone replacement?
- Hypothyroidism (correct)
- Treatment of myxedema coma (correct)
- Suppression of TSH in the treatment/prevention of goiters (correct)
- All of the above
What are the adverse effects of synthetic thyroxine (T4, T3, or both)?
What are the adverse effects of synthetic thyroxine (T4, T3, or both)?
- Few if any when correct dose used (correct)
- Skin reactions, loss of hair (correct)
- Symptoms of hyperthyroidism if dose too high (correct)
- Less predictable effects: cardiac, CNS, difficulty swallowing (correct)
- All of the above
What is the mechanism of action for antithyroid agents (thioamides) used to treat hyperthyroidism?
What is the mechanism of action for antithyroid agents (thioamides) used to treat hyperthyroidism?
- Prevent formation of thyroid hormone within the thyroid cells, lowering the serum level.
- Partially inhibit conversion of T4 to T3.
- Both A and B. (correct)
- None of the above
What are some drug exemplars for antithyroid agents (thioamides)?
What are some drug exemplars for antithyroid agents (thioamides)?
Radioactive iodine is a drug exemplar for the classification of thyroid cancer.
Radioactive iodine is a drug exemplar for the classification of thyroid cancer.
What are the adverse effects of thyroid cancer treatment?
What are the adverse effects of thyroid cancer treatment?
What is the therapeutic use for synthetic vitamin D analogues?
What is the therapeutic use for synthetic vitamin D analogues?
What are some potential adverse effects of synthetic vitamin D analogues?
What are some potential adverse effects of synthetic vitamin D analogues?
What is the mechanism of action for bisphosphonates used to treat Paget's disease?
What is the mechanism of action for bisphosphonates used to treat Paget's disease?
What are some of the side effects associated with bisphosphonates?
What are some of the side effects associated with bisphosphonates?
What are some commonly used bisphosphonates?
What are some commonly used bisphosphonates?
What is the mechanism of action for calcitonins used to treat hypercalcemia and Paget's disease?
What is the mechanism of action for calcitonins used to treat hypercalcemia and Paget's disease?
What are some of the possible side effects associated with calcitonins?
What are some of the possible side effects associated with calcitonins?
Flashcards
Thyroid Hormone Replacement
Thyroid Hormone Replacement
Synthetic form of thyroxine (T4, T3, or both) used to treat hypothyroidism.
Levothyroxine (Synthroid)
Levothyroxine (Synthroid)
A common synthetic thyroid hormone used in hypothyroidism treatment.
Hypothyroidism
Hypothyroidism
A condition of decreased thyroid hormone production.
Myxedema Coma
Myxedema Coma
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Antithyroid Agents
Antithyroid Agents
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Propylthiouracil (PTU)
Propylthiouracil (PTU)
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Methimazole (Tapazole)
Methimazole (Tapazole)
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Radioactive Iodine (RAI)
Radioactive Iodine (RAI)
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Thyrotoxic Crisis/Storm
Thyrotoxic Crisis/Storm
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Potassium Iodide
Potassium Iodide
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Calcitriol
Calcitriol
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Hypocalcemia
Hypocalcemia
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Bisphosphonates
Bisphosphonates
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Alendronate (Fosamax)
Alendronate (Fosamax)
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Paget's Disease
Paget's Disease
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Hypercalcemia
Hypercalcemia
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Calcitonin
Calcitonin
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Calcitonin salmon
Calcitonin salmon
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Parathyroid Hormone
Parathyroid Hormone
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Antihypercalcemic Agents
Antihypercalcemic Agents
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Graves' Disease
Graves' Disease
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Thyroid Cancer
Thyroid Cancer
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Study Notes
Thyroid Hormone Replacement
- Uses: Hypothyroidism treatment, myxedema coma, suppression of TSH to prevent goiters
- Mechanism of Action: Synthetic forms of thyroxine (T4, T3) increase body metabolism, oxygen consumption, respiration, heart rate, growth, and maturation, and fat, carbohydrate, and protein metabolism.
- Adverse Effects: Few adverse effects with correct dosage, but skin reactions, hair loss, and symptoms of hyperthyroidism may occur if the dose is too high. Less predictable effects include cardiac and central nervous system issues, and difficulty swallowing.
Antithyroid Agents
- Uses: Hyperthyroidism treatment
- Mechanism of Action: Prevent thyroid hormone formation in thyroid cells, reducing serum levels. Some also inhibit T4 to T3 conversion.
- Adverse Effects: Effects of thyroid suppression, gastrointestinal issues, possible hypothyroidism, iodism, staining of teeth, skin rash and goiter formation.
Synthetic Vitamin D Analogs (Parathyroid)
- Uses: Hypocalcemia treatment
- Mechanism of Action: Regulate calcium and phosphate absorption from the small intestine, mineral reabsorption in bone, and phosphate reabsorption in renal tubes.
- Adverse Effects: Gastrointestinal issues, central nervous system effects, increased drug level and/or toxicity, and hypercalcemia. Kidney or liver issues can worsen these effects.
Antihypercalcemic Agents
- Uses: Paget's disease treatment
- Mechanism of Action: Slows or blocks bone resorption.
- Adverse Effects: Interruption treatments can lead to severe hypocalcemia. Common side effects include abdominal pain, constipation, musculoskeletal pain, nausea, diarrhea, increased bone pain with Paget's disease, esophageal ulceration, increased risk of femoral shaft fractures, osteonecrosis of the jaw, skin flushing, nausea, vomiting, increased urinary frequency, and local inflammation at injection sites. Intranasal administration can cause dryness and irritation. Many side effects diminish over time.
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Description
Test your knowledge on thyroid hormone replacement and antithyroid agents. This quiz covers their uses, mechanisms of action, and potential adverse effects. Understand how these medications impact thyroid function and metabolism.
