Questions and Answers
Which synthetic compound is used for diagnosing thyroid carcinoma?
TSH
Which thyroid hormone replacement has a longer half-life and is preferred due to its stability?
Levothyroxine (T4)
Which patient group requires lower doses of thyroid hormone replacement due to the hormone's effects on the heart?
Patients with heart disease
Which medication is preferred for hyperactive thyroid conditions during the first trimester of pregnancy?
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Which medication can cause severe hepatic toxicity?
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Which medication can be used as an anti-thyroid agent through high iodine doses?
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Which medication is used to block the sympathetic nervous system in thyroid storm?
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Which medication blocks the conversion of T4 to T3 in thyroid storm treatment?
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Which medication can cause teratogenic effects?
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What is the preferred thyroid hormone replacement due to its long half-life and stability?
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Which medication is used for hyperactive thyroid conditions like Graves' disease by blocking thyroid peroxidase and T4 to T3 conversion?
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In which condition should PTU be preferred over methimazole for treatment due to teratogenic effects?
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What synthetic compound is used to induce iodine uptake in thyroid cells for diagnosing thyroid carcinoma?
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Why do patients with heart disease require lower doses of thyroid hormone replacement?
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Which medication is preferred in the later trimesters of pregnancy due to a switch from PTU for treating hyperactive thyroid conditions?
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What medication can lead to aplastic anemia and teratogenic effects?
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Which medication can be used for partial or complete destruction of the thyroid glands as an anti-thyroid agent?
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In thyroid storm treatment, which medication combination blocks the conversion of T4 to T3?
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Study Notes
- TSH is a synthetic compound used for diagnosing thyroid carcinoma by inducing iodine uptake in thyroid cells.
- Levothyroxine and liothyronine are thyroid hormone replacements, with levothyroxine (T4) being preferred due to its long half-life and stability.
- Dosing of levothyroxine varies based on conditions like pregnancy, oral contraceptive use, hepatic failure, elderly patients, and heart disease.
- Patients with heart disease require lower doses of thyroid hormone replacement due to the hormone's effects on the heart.
- Methimazole and PTU are used for hyperactive thyroid conditions like Graves' disease, blocking thyroid peroxidase and T4 to T3 conversion.
- PTU is preferred in the first trimester of pregnancy due to methimazole's teratogenic effects, switching to methimazole in later trimesters.
- Methimazole can cause aplastic anemia and teratogenic effects, while PTU can lead to severe hepatic toxicity.
- Iodine can be used as an anti-thyroid agent through high iodine doses or radio-labeled iodine for partial or complete destruction of thyroid glands.
- Propranolol is used to block the sympathetic nervous system in thyroid storm, along with methimazole or PTU to inhibit T4 and T3 synthesis.
- Hydrocortisone, propranolol, and PTU block the conversion of T4 to T3 in thyroid storm treatment.
- Plasmapheresis, cholestyramine, surgery (thyroid removal), or radioactive iodine are additional treatments for thyroid storm to remove circulating T4 and T3 and address the underlying cause.
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