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Thyroglobulin Synthesis and Iodide Pump Quiz

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Thyroglobulin Synthesis and Iodide Pump Quiz

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Questions and Answers

What is the primary function of thyroglobulin in the thyroid gland?

To transport iodide into the follicular cells
To be the precursor for the production of thyroid hormones (correct)
To catalyze the oxidation of iodide to iodine
To serve as a structural component of the thyroid follicles

What is the role of the iodide pump or sodium-iodide cotransporter in the thyroid gland?

To transport sodium ions into the follicular cells
To convert iodide to iodine in the follicular cells
To secrete thyroglobulin into the follicular lumen
To actively transport iodide into the follicular cells (correct)

What is the role of thyroid peroxidase in the thyroid gland?

To transport thyroglobulin into the follicular lumen
To synthesize thyroglobulin in the follicular cells
To actively transport sodium ions into the follicular cells
To catalyze the oxidation of iodide to iodine (correct)

How is thyroglobulin secreted into the follicular lumen?

By exocytosis of secretory vesicles containing thyroglobulin (B) Signup and view all the answers

What is the significance of the numerous tyrosine amino acids on each thyroglobulin molecule?

They are used as precursors for the production of thyroid hormones (D) Signup and view all the answers

Which autoimmune condition is associated with circulating TSH receptor autoantibodies?

Graves disease (C) Signup and view all the answers

What is the primary clinical state found in Graves disease?

Thyrotoxicosis (A) Signup and view all the answers

What are thyroid stimulating immunoglobulins (TSI) in Graves disease?

Autoantibodies targeting TSH receptors (B) Signup and view all the answers

Which condition is characterized by abnormal growths within the thyroid gland?

Toxic multinodular goiter (A) Signup and view all the answers

What causes focal and/or diffuse hyperplasia of thyroid follicular cells leading to hyperthyroidism?

Antithyroid antibodies (C) Signup and view all the answers