Free Triiodothyronine (FT3) and Thyroglobulin: Clinical Utility and Interpretation

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Questions and Answers

What is the reference range for Thyroxine (T4) levels?

  • 0.9–1.7 ng/dL
  • 80–200 ng/dL
  • 2.5–5.0 mIU/L
  • 0.4–4.0 mIU/L (correct)

What percentage of Triiodothyronine (T3) is derived from the deiodination of T4?

  • 20%
  • 40%
  • 60%
  • 80% (correct)

What is the reference range for Free Thyroxine (FT4) levels?

  • 0.4–4.0 mIU/L
  • 0.9–1.7 ng/dL (correct)
  • 80–200 ng/dL
  • 2.5–5.0 mIU/L

Which of the following is the biologically active fraction of T4?

<p>Free T4 (FT4) (D)</p> Signup and view all the answers

Which of the following can interfere with the measurement of Free Thyroxine (FT4) levels?

<p>Both thyroid autoantibodies/biotin and HAMA (C)</p> Signup and view all the answers

What is the ideal use of Thyroglobulin as a diagnostic test?

<p>Detecting thyroid cancer recurrence post-surgery (A)</p> Signup and view all the answers

Which assay is used to detect Thyroglobulin, ensuring its detection even when undetectable?

<p>Immunochemiluminescent assay (ICMA) (C)</p> Signup and view all the answers

What is the main cause of hyperthyroidism in Graves’ disease?

<p>Antibodies directed at the TSH receptor (C)</p> Signup and view all the answers

Which test is primarily used for diagnosing Hashimoto’s thyroiditis?

<p>Thyroglobulin Antibody test (B)</p> Signup and view all the answers

How are antibodies against thyroglobulin (Tg) produced?

<p>Through autoimmune hypothyroidism (C)</p> Signup and view all the answers

What diagnostic tool is used to confirm hyperthyroidism in patients with an altered distribution of thyroid binding proteins?

<p>Free Triiodothyronine (FT3) test (C)</p> Signup and view all the answers

Which gland is responsible for the production of thyroid hormone and calcitonin?

<p>Thyroid gland (B)</p> Signup and view all the answers

What is the anatomical position of the thyroid gland?

<p>Lower anterior neck (C)</p> Signup and view all the answers

Which of the following is rich in the amino acid tyrosine and is a major component of colloid in the thyroid follicles?

<p>Thyroglobulin (A)</p> Signup and view all the answers

What is the main function of Type 1 iodothyronine 5'-deiodinase?

<p>Most abundant form, contributes to the circulating T3 pool (C)</p> Signup and view all the answers

Which enzyme catalyzes the oxidation and binding of iodide with tyrosyl residues on thyroglobulin in the thyroid follicles?

<p>Thyroid peroxidase (TPO) (D)</p> Signup and view all the answers

What is the precursor with minimal hormonal effect and stored in the thyroid lumen filled with colloid?

<p>Thyroglobulin (A)</p> Signup and view all the answers

Which hormone is released from the anterior pituitary to signal the follicular cell to ingest a droplet of colloid by endocytosis?

<p>Thyroid-stimulating hormone (TSH) (B)</p> Signup and view all the answers

What hormone is considered a prohormone precursor with minimal hormonal effect?

<p>Thyroglobulin (A)</p> Signup and view all the answers

What is the main function of Type 2 iodothyronine 5'-deiodinase?

<p>Maintains constant levels of T3 in the central nervous system (A)</p> Signup and view all the answers

What are the effects of Thyroid Hormone on Tissue growth, Brain maturation, Energy production, and Oxygen consumption primarily due to?

<p>Increased expression of β-adrenergic receptors (B)</p> Signup and view all the answers

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