21 Questions
What is the reference range for Thyroxine (T4) levels?
0.4–4.0 mIU/L
What percentage of Triiodothyronine (T3) is derived from the deiodination of T4?
80%
What is the reference range for Free Thyroxine (FT4) levels?
0.9–1.7 ng/dL
Which of the following is the biologically active fraction of T4?
Free T4 (FT4)
Which of the following can interfere with the measurement of Free Thyroxine (FT4) levels?
Both thyroid autoantibodies/biotin and HAMA
What is the ideal use of Thyroglobulin as a diagnostic test?
Detecting thyroid cancer recurrence post-surgery
Which assay is used to detect Thyroglobulin, ensuring its detection even when undetectable?
Immunochemiluminescent assay (ICMA)
What is the main cause of hyperthyroidism in Graves’ disease?
Antibodies directed at the TSH receptor
Which test is primarily used for diagnosing Hashimoto’s thyroiditis?
Thyroglobulin Antibody test
How are antibodies against thyroglobulin (Tg) produced?
Through autoimmune hypothyroidism
What diagnostic tool is used to confirm hyperthyroidism in patients with an altered distribution of thyroid binding proteins?
Free Triiodothyronine (FT3) test
Which gland is responsible for the production of thyroid hormone and calcitonin?
Thyroid gland
What is the anatomical position of the thyroid gland?
Lower anterior neck
Which of the following is rich in the amino acid tyrosine and is a major component of colloid in the thyroid follicles?
Thyroglobulin
What is the main function of Type 1 iodothyronine 5'-deiodinase?
Most abundant form, contributes to the circulating T3 pool
Which enzyme catalyzes the oxidation and binding of iodide with tyrosyl residues on thyroglobulin in the thyroid follicles?
Thyroid peroxidase (TPO)
What is the precursor with minimal hormonal effect and stored in the thyroid lumen filled with colloid?
Thyroglobulin
Which hormone is released from the anterior pituitary to signal the follicular cell to ingest a droplet of colloid by endocytosis?
Thyroid-stimulating hormone (TSH)
What hormone is considered a prohormone precursor with minimal hormonal effect?
Thyroglobulin
What is the main function of Type 2 iodothyronine 5'-deiodinase?
Maintains constant levels of T3 in the central nervous system
What are the effects of Thyroid Hormone on Tissue growth, Brain maturation, Energy production, and Oxygen consumption primarily due to?
Increased expression of β-adrenergic receptors
Learn about Free Triiodothyronine (FT3) as a biologically active form of T3 used in the further confirmation of hyperthyroidism. Explore the significance of Thyroglobulin, a protein exclusively synthesized by thyroid follicular cells, with applications in evaluating clinically euthyroid patients with altered distribution of thyroid binding proteins.
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