Thrombosis and Erythrocytes

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Questions and Answers

What is the primary function of erythrocytes, which is facilitated by hemoglobin?

  • Transporting oxygen and carbon dioxide throughout the body. (correct)
  • Promoting blood clotting at the site of damaged blood vessels.
  • Producing platelets at a rate of approximately 1x10^11 per day.
  • Generating new organelles within bone marrow.

Which characteristic distinguishes erythrocytes from megakaryocytes?

  • Erythrocytes are generated by budding; megakaryocytes are generated in bone marrow.
  • Erythrocytes have a lifespan of 5-9 days; megakaryocytes have a lifespan of 120 days.
  • Erythrocytes promote blood clotting; megakaryocytes transport oxygen.
  • Erythrocytes lack a nucleus and other organelles; megakaryocytes generate platelets. (correct)

If approximately 1% of erythrocytes must be replaced daily to maintain equilibrium, about how many erythrocytes need to be replaced each hour?

  • 10^5/hour
  • 10^7/hour
  • 10^11/hour
  • 10^9/hour (correct)

What role do megakaryocytes play in hemostasis?

<p>They generate platelets, which promote blood clotting. (C)</p> Signup and view all the answers

What is the approximate diameter range of erythrocytes?

<p>7.5-8 μm (A)</p> Signup and view all the answers

What is the biconcave disc shape of erythrocytes important for?

<p>To increase the surface area for gas exchange. (B)</p> Signup and view all the answers

How does the absence of a nucleus and other organelles affect the functionality of erythrocytes?

<p>It increases the space available for hemoglobin, improving oxygen-carrying capacity. (C)</p> Signup and view all the answers

Which component of hemoglobin directly binds to oxygen?

<p>Heme containing iron (Fe2+) (A)</p> Signup and view all the answers

What aspect of erythrocyte production does the term '1x10^11 platelets/day produced by a healthy individual' describe?

<p>The average daily production rate of platelets by megakaryocytes. (B)</p> Signup and view all the answers

What is indicated by the phrase 'Erythrocytes (44% of whole blood)'?

<p>Erythrocytes constitute 44% of the total blood volume. (D)</p> Signup and view all the answers

What is the lifespan of a typical erythrocyte?

<p>120 days (A)</p> Signup and view all the answers

What does the term 'thrombosis' refer to in the context of blood physiology?

<p>The formation of blood clots. (D)</p> Signup and view all the answers

If a patient's erythrocyte production rate decreases significantly, what direct physiological consequence is most likely?

<p>Reduced oxygen-carrying capacity. (B)</p> Signup and view all the answers

What might be affected if the bone marrow is damaged and cannot produce megakaryocytes effectively?

<p>The ability to clot blood would be impaired. (B)</p> Signup and view all the answers

Which of the following is a key structural feature of erythrocytes that directly aids their function?

<p>A biconcave disc shape. (A)</p> Signup and view all the answers

What is the primary role of the iron (Fe2+) component within hemoglobin?

<p>To enable the binding and transport of oxygen. (D)</p> Signup and view all the answers

How does the daily replacement of approximately 1% of erythrocytes relate to maintaining physiological equilibrium?

<p>It ensures a constant supply of functional oxygen-carrying cells. (B)</p> Signup and view all the answers

If an individual has a condition that reduces the production of hemoglobin, what direct effect would this have on their erythrocytes?

<p>Reduced oxygen-carrying capacity. (D)</p> Signup and view all the answers

What immediate effect would a significant decrease in the number of circulating platelets have on an individual's health?

<p>Impaired ability to control bleeding. (A)</p> Signup and view all the answers

What adaptation of erythrocytes is most effective for navigating through narrow capillaries to deliver oxygen to tissues?

<p>Their small size and biconcave disc shape. (C)</p> Signup and view all the answers

Following the breakdown of heme, what is the immediate fate of bilirubin before it is further processed for excretion?

<p>It is carried to the liver and secreted into bile. (A)</p> Signup and view all the answers

Which of the following is a critical component required for the transportation of iron in the bloodstream, which is later used in erythropoiesis?

<p>Transferrin (B)</p> Signup and view all the answers

What initiates the process of erythropoiesis when normal blood oxygen levels decrease?

<p>The kidneys and liver secrete erythropoietin. (C)</p> Signup and view all the answers

What is the primary fate of globin molecules after an erythrocyte is broken down?

<p>They are broken down into amino acids and reused. (C)</p> Signup and view all the answers

In the erythrocyte breakdown process, what is the role of macrophages?

<p>They phagocytose and break down aged or damaged erythrocytes. (A)</p> Signup and view all the answers

How does high-altitude training stimulate erythropoiesis?

<p>By reducing oxygen availability, stimulating EPO production. (A)</p> Signup and view all the answers

Which sequence accurately describes the transformation of heme after the destruction of erythrocytes?

<p>Heme → Biliverdin → Bilirubin → Urobilinogen (A)</p> Signup and view all the answers

What role do cytokines, growth factors, and hormones play in erythropoiesis?

<p>They influence erythroid proliferation, differentiation, and maturation. (C)</p> Signup and view all the answers

Where does the conversion of urobilinogen into stercobilin primarily occur?

<p>In the large intestine (D)</p> Signup and view all the answers

Which process describes the regulation of erythrocyte production, where erythropoietin (EPO) plays a central role?

<p>A negative feedback loop responding to blood oxygen levels. (A)</p> Signup and view all the answers

What is the primary form in which iron is stored within cells like hepatocytes and macrophages?

<p>Ferritin (D)</p> Signup and view all the answers

What is the life span of erythrocytes, approximately?

<p>120 days (D)</p> Signup and view all the answers

What effect do bile acids have on bilirubin, facilitating its excretion?

<p>Bile acids make bilirubin more soluble, aiding its excretion. (D)</p> Signup and view all the answers

What stimulates the kidneys to release erythropoietin (EPO)?

<p>Low blood oxygen levels (B)</p> Signup and view all the answers

Which of the following organs is NOT a primary site for macrophage-mediated erythrocyte breakdown?

<p>Kidney (A)</p> Signup and view all the answers

What is the ultimate fate of most urobilinogen produced in the large intestine?

<p>It is converted to stercobilin and excreted in feces. (B)</p> Signup and view all the answers

After iron (Fe3+) is released during the breakdown of hemoglobin, what glycoprotein is responsible for transporting it in the blood?

<p>Transferrin (B)</p> Signup and view all the answers

Following the phagocytosis of erythrocytes by macrophages, which enzyme is responsible for the initial degradation of hemoglobin (Hb)?

<p>Protease (D)</p> Signup and view all the answers

What is the role of erythropoietin in the bone marrow during erythropoiesis?

<p>It stimulates the proliferation and differentiation of erythroid progenitor cells. (D)</p> Signup and view all the answers

In the recycling process of erythrocytes components, what substance is produced from the degradation of heme and subsequently gives bile its color?

<p>Bilirubin (D)</p> Signup and view all the answers

For treating a patient with a genetic disorder that impairs their ability to produce certain clotting factors, which blood component would be most suitable for therapeutic use?

<p>Fresh frozen plasma (C)</p> Signup and view all the answers

What is the MOST direct effect of administering a saline solution to a patient who has experienced blood loss exceeding 1.5L?

<p>Increasing blood volume (A)</p> Signup and view all the answers

A blood sample shows a hematocrit value outside the normal range. What can this imply about the blood's characteristics?

<p>Indication of the proportion of erythrocytes and leukocytes, useful in estimating oxygen-carrying capacity. (B)</p> Signup and view all the answers

What is the purpose of refrigerating donated blood at 4°C overnight before separation?

<p>To minimize bacterial growth and preserve blood component integrity (B)</p> Signup and view all the answers

If a patient needs a blood transfusion, but most of the plasma and leukocytes must be removed, which blood product would be the MOST appropriate?

<p>Packed red blood cells (C)</p> Signup and view all the answers

What is the clinical significance of determining the hematocrit level in a patient's blood sample?

<p>To determine the proportion of blood composed of erythrocytes and leukocytes, crucial for oxygen transport. (B)</p> Signup and view all the answers

How does the composition of packed red blood cells (RBCs) differ from that of whole blood?

<p>Packed RBCs have most of the plasma and leukocytes removed. (A)</p> Signup and view all the answers

Which condition would MOST warrant the use of activated coagulation factors derived from donated blood?

<p>Uncontrolled bleeding due to a deficiency in clotting factors (A)</p> Signup and view all the answers

If a male patient has a hematocrit value of 0.39, what inference can be made based on the provided normal ranges?

<p>His hematocrit is below the normal range for males. (D)</p> Signup and view all the answers

What does the 'buffy coat,' found between the red blood cells and plasma in a centrifuged blood sample, primarily consist of?

<p>Leukocytes and platelets (D)</p> Signup and view all the answers

A laboratory receives a 450 mL unit of blood collected into an anticoagulant. What is the immediate next step in processing this donation?

<p>Separation into individual components after overnight refrigeration (A)</p> Signup and view all the answers

Why is blood often processed into separate components, such as packed red blood cells, fresh frozen plasma, and platelets, rather than being used as whole blood for transfusions?

<p>To maximize the number of patients who can benefit from a single donation and to tailor treatment to the patient's specific needs (C)</p> Signup and view all the answers

When transfusing blood products, why is it important to perform compatibility testing, especially for red blood cells?

<p>To ensure the donor and recipient have compatible blood types to prevent transfusion reactions (B)</p> Signup and view all the answers

Following the separation of blood components, fresh frozen plasma is stored at -25°C. What is the primary reason for this?

<p>To preserve the activity of coagulation factors and other proteins (C)</p> Signup and view all the answers

What is the purpose of using an anticoagulant when collecting blood for donation?

<p>To prevent the blood from clotting, allowing for separation and storage (C)</p> Signup and view all the answers

What is the MOST important reason for testing donated blood for various infectious diseases?

<p>To prevent transfusion-transmitted infections in recipients (C)</p> Signup and view all the answers

Why are fresh frozen plasma transfusions especially beneficial for individuals with genetic disorders affecting coagulation?

<p>They provide essential coagulation factors that these individuals may not produce sufficiently. (D)</p> Signup and view all the answers

What is the SIGNIFICANCE of knowing the normal hematocrit ranges for males and females?

<p>To assess for anemia or polycythemia, as normal ranges differ between sexes. (B)</p> Signup and view all the answers

In the context of blood transfusions, what considerations should be addressed when using blood components stored at different temperatures?

<p>Avoiding mixing components stored under different conditions until compatibility is confirmed. (B)</p> Signup and view all the answers

What is the expected outcome of administering fibrinolysis inhibitors to a patient?

<p>Prevention of excessive clot breakdown, stabilizing existing clots. (A)</p> Signup and view all the answers

Flashcards

Thrombosis

Formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system.

Most abundant blood cells

The most abundant cells in the blood.

Platelet Function

Promote blood clotting when blood vessels are damaged.

Platelet Production

Platelets are generated in bone marrow by budding off from megakaryocytes, each producing 5-10,000 platelets.

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Platelet Lifespan

The lifespan of platelets is approximately 5-9 days.

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Red Blood Cell Lifespan

The lifespan of a red blood cell is approximately 120 days.

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Red Blood Cell Composition

Red blood cells lack a nucleus and other organelles.

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Red Blood Cell Function

RBCs transport O2 and CO2 facilitated by hemoglobin (Hb).

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Erythropoiesis

Process that generates mature erythrocytes.

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Erythrocyte breakdown

Process by which red blood cells are broken down.

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Erythropoietin (EPO)

Hormone that regulates erythrocyte production in a feedback process.

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Cytokines, growth factors, and hormones

Factor influencing erythroid proliferation, differentiation, and maturation.

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High altitude training

Process of adaptation to reduced oxygen availability at high altitudes, enhancing erythropoiesis.

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Globin breakdown

Where hemoglobin is broken down into amino acids for reuse.

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Heme degradation

The fate of heme after being metabolized.

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Ferritin

How iron is stored.

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Red blood cell phagocytosis

Macrophage location where aged red blood cells are phagocytosed.

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Transferrin

Transports iron to bone marrow for new erythrocyte synthesis

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Proteases

Degraded by these. Happens to hemoglobin in lysosomes of macrophages

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urobilinogen

Becomes stercobilin/urobilin in the large intestine

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Blood Donation Volume

450mL of blood collected with an anticoagulant.

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Blood Processing

Blood is refrigerated overnight at 4°C, then separated.

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Saline Use in Blood Loss

Saline solution can increase blood volume in patients

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Buffy Coat

Blood component with white blood cells and platelets.

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Packed Red Blood Cells

Whole blood with most of the plasma and leukocytes removed.

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Hematocrit

Used to estimate erythrocyte proportion in blood, indicating O2 carrying capacity.

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Hematocrit Definition

Proportion of blood volume made up by cells (erythrocytes + leukocytes).

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Packed Cell Volume

Proportion of blood made up by cells (red and white). Expressed as a ratio.

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Coagulation Factors Replacement

Replacement coagulation factors are administered to patients with genetic disorders.

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Activated Coagulation Factors

Activated coagulation factors (e.g., Factor VIIa, thrombin)

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Blood plasma

Liquid component of blood (55%)

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Study Notes

  • Haematocrit is useful to estimate proportion of erythrocytes in a blood sample to indicate O2 carrying capacity.
  • Proportion of blood made up by cells (erythrocytes + leukocytes).
  • Blood donation occurs when you need blood.
  • Saline, a salt solution, can be used to increase blood volume (for loss of <1.5L).
  • Given as a ratio.
  • 1 unit = 450mL, collected into anticoagulant.
  • Blood consists of 55% plasma and 45% red blood cells.
  • The buffy coat is composed of white blood cells and platelets.
  • Also known as packed cell volume (PCV).
  • Normal haematocrit is 0.47 (0.42-0.54) for males and 0.42 (0.37-0.47) for females.
  • Donations are refrigerated (4°C) overnight, then separated.
  • Donations are processed into blood components using a filter to remove leukocytes.
  • Blood components include fresh frozen plasma, platelets, and packed red blood cells.
  • Packed RBCs is whole blood from which most of the plasma and leukocytes have been removed.
  • Replacement coagulation factors are done for patients with genetic disorders.
  • Activated coagulation factors, e.g., factor VIIIa, thrombin.
  • Fibrinolysis inhibitors exist.

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