L6 (T1): Physiology of thirst and fluid balance
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Questions and Answers

Which hormone is known as an 'anti-diuretic hormone' and plays a role in the regulation of thirst and fluid balance?

  • Oxytocin
  • Arginine vasopressin (AVP) (correct)
  • Insulin
  • Adrenaline

What is the narrow range of plasma osmolality that ensures stable water balance?

  • 400-420 mosmol/kg
  • 320-350 mosmol/kg
  • 200-220 mosmol/kg
  • 285-295 mosmol/kg (correct)

What is the primary determinant of water balance regulation?

  • Arginine vasopressin (AVP) (correct)
  • Blood pressure
  • Sodium levels
  • Oxytocin

What is the condition characterized by excessive urine production and increased thirst?

<p>Diabetes Insipidus (DI) (D)</p> Signup and view all the answers

What is the condition characterized by low sodium levels in the blood and excessive secretion of ADH?

<p>Syndrome of inappropriate ADH secretion (SIADH) (A)</p> Signup and view all the answers

What is the hormone that acts on the renal tubule to allow changes in water excretion?

<p>Arginine vasopressin (AVP) (C)</p> Signup and view all the answers

What is the main hormone responsible for osmotically stimulated secretion of ADH?

<p>Arginine vasopressin (AVP) (B)</p> Signup and view all the answers

What is the water deprivation test used to investigate?

<p>Diabetes Insipidus (DI) (B)</p> Signup and view all the answers

What is the condition characterized by excessive thirst?

<p>Polydipsia (D)</p> Signup and view all the answers

What is the condition characterized by low sodium levels in the blood?

<p>Hyponatraemia (B)</p> Signup and view all the answers

Which cells detect changes in plasma osmolality?

<p>Osmoreceptor cells (C)</p> Signup and view all the answers

Where are osmoreceptors located?

<p>Anterior wall of 3rd ventricle (D)</p> Signup and view all the answers

What initiates neuronal impulses that are transmitted to the hypothalamus and cerebral cortex?

<p>Osmoreceptor cell volume change (D)</p> Signup and view all the answers

What is the human form of ADH?

<p>Arginine vasopressin (AVP) (A)</p> Signup and view all the answers

Where is vasopressin synthesized in the body?

<p>Supraoptic and paraventricular nuclei of the hypothalamus (A)</p> Signup and view all the answers

What does AVP action mediated via?

<p>V2 receptors (D)</p> Signup and view all the answers

What does AVP-sensitive water channel promote in the kidney?

<p>Water reabsorption (C)</p> Signup and view all the answers

What happens to water channels when AVP is cleared?

<p>They are removed from the luminal surface (B)</p> Signup and view all the answers

What happens to AVP secretion and thirst when plasma osmolality is high?

<p>AVP secretion and thirst increase (C)</p> Signup and view all the answers

What are the three main causes of polyuria and polydipsia, excluding diabetes mellitus?

<p>Cranial (central) diabetes insipidus (DI), Nephrogenic diabetes insipidus (DI), and Primary polydipsia (A)</p> Signup and view all the answers

Which topic is the focus of the lecture?

<p>The physiology of thirst and fluid balance (B)</p> Signup and view all the answers

According to the speaker, why is the topic of fluid balance considered tricky?

<p>Because it is inherently confusing (A)</p> Signup and view all the answers

What hormone is associated with the condition called diabetes insipidus?

<p>Posterior pituitary hormone (D)</p> Signup and view all the answers

What is the condition characterized by excess urination and excessive thirst?

<p>Diabetes insipidus (B)</p> Signup and view all the answers

Which receptors does AVP act on in the kidneys?

<p>V2 receptors (B)</p> Signup and view all the answers

During water reabsorption, where do the aquaporin channels move to?

<p>Luminal membrane (A)</p> Signup and view all the answers

What happens to AVP secretion and thirst when plasma osmolarity is low?

<p>AVP secretion decreases and thirst is suppressed (A)</p> Signup and view all the answers

What is the physiological response to high plasma osmolarity?

<p>Increased AVP secretion and concentrated urine (D)</p> Signup and view all the answers

Which of the following is a characteristic of cranial diabetes insipidus?

<p>Inability to concentrate urine during water deprivation (A)</p> Signup and view all the answers

What is the main treatment for cranial diabetes insipidus?

<p>Desmopressin (B)</p> Signup and view all the answers

Which of the following can cause nephrogenic diabetes insipidus?

<p>Nonsteroidal drugs (A)</p> Signup and view all the answers

What is the potential risk of taking excessive Desmopressin?

<p>Fluid overload (B)</p> Signup and view all the answers

What is the term used to describe a condition in which the renal tubules are resistant to AVP?

<p>Diabetes insipidus (B)</p> Signup and view all the answers

What is the term used to describe excessive thirst?

<p>Polydipsia (C)</p> Signup and view all the answers

What can trigger resistance to AVP in some individuals?

<p>All of the above (D)</p> Signup and view all the answers

What is the term used to describe a condition in which a person drinks excessive amounts of fluid?

<p>Psychogenic polydipsia (A)</p> Signup and view all the answers

Which hormone deficiency is characterized by excessive thirst and urine production?

<p>Diabetes insipidus (D)</p> Signup and view all the answers

What are the three main causes of diabetes insipidus?

<p>Central cranio, Neff Genic, primary politics (C)</p> Signup and view all the answers

Which condition is characterized by a deficiency of AVP and can be genetic or idiopathic?

<p>Central cranio diabetes insipidus (A)</p> Signup and view all the answers

Which hormone deficiency can lead to disordered thirst, appetite, temperature regulation, and sleep rhythm?

<p>Diabetes insipidus (C)</p> Signup and view all the answers

Which of the following is a symptom of mild and chronic hyponatremia?

<p>Headache (B)</p> Signup and view all the answers

What can cause sudden hyponatremia?

<p>Head injury (B)</p> Signup and view all the answers

What is the severe level of hyponatremia?

<p>Less than 1 to 5 (D)</p> Signup and view all the answers

What is the key regulator of mortality in hyponatremia?

<p>Sodium (A)</p> Signup and view all the answers

What can happen to the brain when hyponatremia is slow and chronic?

<p>Adapt (C)</p> Signup and view all the answers

What are non-specific symptoms of hyponatremia?

<p>Headache, nausea, low mood (D)</p> Signup and view all the answers

What is the hormone responsible for water conservation in the body?

<p>Arginine vasopressin (D)</p> Signup and view all the answers

What are the main ways by which water homeostasis is regulated in the body?

<p>Hormonal regulation, thirst, and urine production (A)</p> Signup and view all the answers

Where is the hormone AVP synthesized in the body?

<p>Hypothalamus (D)</p> Signup and view all the answers

What stimulates fluid intake in the body?

<p>Thirst (B)</p> Signup and view all the answers

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