Podcast
Questions and Answers
Which cells present peptides from endogenous proteins?
Which cells present peptides from endogenous proteins?
- CD8+ T cells (correct)
- CD4+ T cells
- B cells
- APCs
What type of cells recognize MHC class II?
What type of cells recognize MHC class II?
- CD4+ T cells (correct)
- B cells
- CD8+ T cells
- APCs
Why do T cells need to work with antigen presenting cells?
Why do T cells need to work with antigen presenting cells?
- To determine which peptides will be presented during initial activation (correct)
- To distinguish between external and internal antigens
- To recognize native antigens
- To present peptides on MHC class I and II
What is the main difference between B cells and T cells in recognizing antigens?
What is the main difference between B cells and T cells in recognizing antigens?
What type of peptides does MHC class II present?
What type of peptides does MHC class II present?
What cells need to be able to distinguish between external and internal antigens?
What cells need to be able to distinguish between external and internal antigens?
What is the purpose of antigen processing and presentation?
What is the purpose of antigen processing and presentation?
Which cells recognize MHC class I?
Which cells recognize MHC class I?
What is the email address of Chris Pepper?
What is the email address of Chris Pepper?
What is the learning outcome of the lecture?
What is the learning outcome of the lecture?
Which type of antigen is presented on Class I MHC molecules to CD8+ T cells?
Which type of antigen is presented on Class I MHC molecules to CD8+ T cells?
Which cellular compartment is responsible for the generation of Class I MHC peptides?
Which cellular compartment is responsible for the generation of Class I MHC peptides?
What is the role of TAP proteins in antigen processing?
What is the role of TAP proteins in antigen processing?
Which type of antigens activate cytotoxic CD8+ T cells for killing infected cells and tumor cells?
Which type of antigens activate cytotoxic CD8+ T cells for killing infected cells and tumor cells?
Which viral protein can selectively bind to TAP and inhibit the transfer of peptides into the ER?
Which viral protein can selectively bind to TAP and inhibit the transfer of peptides into the ER?
Which pathway is responsible for generating peptides bound to MHC Class II molecules?
Which pathway is responsible for generating peptides bound to MHC Class II molecules?
What prevents MHC Class II from binding self peptides in the ER?
What prevents MHC Class II from binding self peptides in the ER?
Which type of antigens activate CD4+ T cells?
Which type of antigens activate CD4+ T cells?
Which viral protein reduces MHC Class II processing and inhibits the production of invariant chain peptide?
Which viral protein reduces MHC Class II processing and inhibits the production of invariant chain peptide?
What is the sequence of events in a T cell dependent B cell response?
What is the sequence of events in a T cell dependent B cell response?
Which type of peptides are recognized by CD8+ T cells?
Which type of peptides are recognized by CD8+ T cells?
What is the main function of CD8+ T cells?
What is the main function of CD8+ T cells?
Which type of cells present antigens on MHC class II molecules?
Which type of cells present antigens on MHC class II molecules?
What is the role of MHC class II molecules?
What is the role of MHC class II molecules?
How are exogenous antigens processed in the cell?
How are exogenous antigens processed in the cell?
Which type of cells recognize MHC class I molecules?
Which type of cells recognize MHC class I molecules?
What is the function of MHC class II molecules?
What is the function of MHC class II molecules?
Why do T cells need antigen presenting cells?
Why do T cells need antigen presenting cells?
Which type of antigens can B cells recognize?
Which type of antigens can B cells recognize?
What is the main difference between B cells and T cells in recognizing antigens?
What is the main difference between B cells and T cells in recognizing antigens?
What is the cellular compartment where MHC Class I molecules load peptides?
What is the cellular compartment where MHC Class I molecules load peptides?
Which accessory proteins are involved in peptide loading of MHC Class II molecules?
Which accessory proteins are involved in peptide loading of MHC Class II molecules?
What is the fate of a B cell after it becomes an experienced antigen?
What is the fate of a B cell after it becomes an experienced antigen?
What is the main function of plasma cells?
What is the main function of plasma cells?
Which type of T cells recognize antigens presented on MHC Class II molecules?
Which type of T cells recognize antigens presented on MHC Class II molecules?
What is the function of lysosomes in antigen processing and presentation?
What is the function of lysosomes in antigen processing and presentation?
Where do MHC class II molecules encounter antigens?
Where do MHC class II molecules encounter antigens?
What prevents endogenous peptides from binding to MHC class II molecules in the endoplasmic reticulum?
What prevents endogenous peptides from binding to MHC class II molecules in the endoplasmic reticulum?
Where are MHC class II molecules loaded with peptides?
Where are MHC class II molecules loaded with peptides?
How do viruses evade MHC class II antigen presentation?
How do viruses evade MHC class II antigen presentation?
What is the role of antigen presenting cells in the immune response?
What is the role of antigen presenting cells in the immune response?
Which cells can act as antigen presenting cells?
Which cells can act as antigen presenting cells?
What is the main difference between MHC Class I and MHC Class II molecules?
What is the main difference between MHC Class I and MHC Class II molecules?
What is the function of TAP proteins in antigen processing?
What is the function of TAP proteins in antigen processing?
What is the significance of the turnover of proteins inside a cell?
What is the significance of the turnover of proteins inside a cell?
Which type of peptides are presented on MHC Class II molecules?
Which type of peptides are presented on MHC Class II molecules?
What is the main difference between MHC Class I and MHC Class II molecules?
What is the main difference between MHC Class I and MHC Class II molecules?
What is the role of MHC Class I molecules in antigen presentation?
What is the role of MHC Class I molecules in antigen presentation?
What is the purpose of antigen processing and presentation?
What is the purpose of antigen processing and presentation?
What happens to MHC Class II molecules after they present peptides to CD4+ T cells?
What happens to MHC Class II molecules after they present peptides to CD4+ T cells?
Which enzyme is responsible for the genetic recombination of variable, diversity, and joining regions in B cells and T cells?
Which enzyme is responsible for the genetic recombination of variable, diversity, and joining regions in B cells and T cells?
What is the process called that refines B cell receptor recognition of antigen?
What is the process called that refines B cell receptor recognition of antigen?
What is the last step in a B cell's response to antigen, which replaces the constant region of the antibody?
What is the last step in a B cell's response to antigen, which replaces the constant region of the antibody?
Which pathway is responsible for processing exogenous antigens, such as pathogens?
Which pathway is responsible for processing exogenous antigens, such as pathogens?
Which cellular compartment is responsible for breaking down exogenous antigens into peptides?
Which cellular compartment is responsible for breaking down exogenous antigens into peptides?
Which type of T cells recognize MHC class II complexed peptides?
Which type of T cells recognize MHC class II complexed peptides?
Which type of T cells recognize MHC class I complexed peptides?
Which type of T cells recognize MHC class I complexed peptides?
What is the main function of CD40L on T cells and CD40 on B cells?
What is the main function of CD40L on T cells and CD40 on B cells?
Which type of cells present antigens on MHC class II molecules?
Which type of cells present antigens on MHC class II molecules?
What is the purpose of antigen processing and presentation?
What is the purpose of antigen processing and presentation?
Which cells express CD3 and either CD4 or CD8?
Which cells express CD3 and either CD4 or CD8?
Where do B cells and T cells develop?
Where do B cells and T cells develop?
What is the purpose of positive selection in B cells and T cells?
What is the purpose of positive selection in B cells and T cells?
How do B cells and T cells generate an immune response?
How do B cells and T cells generate an immune response?
Which type of T cells recognize MHC class II molecules?
Which type of T cells recognize MHC class II molecules?
How do B cells take up antigen?
How do B cells take up antigen?
Which cells are capable of recognizing a large range of pathogens via pattern recognition receptors?
Which cells are capable of recognizing a large range of pathogens via pattern recognition receptors?
Which type of cells undergo positive and negative selection?
Which type of cells undergo positive and negative selection?
Which type of cells need antigen to be processed into peptides and presented in the context of MHC molecules?
Which type of cells need antigen to be processed into peptides and presented in the context of MHC molecules?
Which type of cells express CD19 and CD20?
Which type of cells express CD19 and CD20?
