T1 L6: Adaptive immunity 3 (CP)

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Which cells present peptides from endogenous proteins?

CD8+ T cells (correct)

CD4+ T cells

B cells

APCs

What type of cells recognize MHC class II?

CD4+ T cells (correct)

B cells

CD8+ T cells

APCs

Why do T cells need to work with antigen presenting cells?

To determine which peptides will be presented during initial activation (correct)

To distinguish between external and internal antigens

To recognize native antigens

To present peptides on MHC class I and II

What is the main difference between B cells and T cells in recognizing antigens?

B cells recognize native antigens Signup and view all the answers

What type of peptides does MHC class II present?

Exogenous peptides Signup and view all the answers

What cells need to be able to distinguish between external and internal antigens?

CD8+ T cells Signup and view all the answers

What is the purpose of antigen processing and presentation?

To understand T cell reliance on antigen presenting cells Signup and view all the answers

Which cells recognize MHC class I?

CD8+ T cells Signup and view all the answers

What is the email address of Chris Pepper?

<a href="mailto:[email protected]">[email protected]</a> Signup and view all the answers

What is the learning outcome of the lecture?

To understand T cell reliance on antigen presenting cells Signup and view all the answers

Which type of antigen is presented on Class I MHC molecules to CD8+ T cells?

Endogenous antigens Signup and view all the answers

Which cellular compartment is responsible for the generation of Class I MHC peptides?

Cytoplasm Signup and view all the answers

What is the role of TAP proteins in antigen processing?

Facilitating selective transport of peptides into the ER Signup and view all the answers

Which type of antigens activate cytotoxic CD8+ T cells for killing infected cells and tumor cells?

Endogenous antigens Signup and view all the answers

Which viral protein can selectively bind to TAP and inhibit the transfer of peptides into the ER?

ICP47 Signup and view all the answers

Which pathway is responsible for generating peptides bound to MHC Class II molecules?

Endocytic processing pathway Signup and view all the answers

What prevents MHC Class II from binding self peptides in the ER?

Invariant chain (Ii) Signup and view all the answers

Which type of antigens activate CD4+ T cells?

Exogenous antigens Signup and view all the answers

Which viral protein reduces MHC Class II processing and inhibits the production of invariant chain peptide?

Glycoprotein B Signup and view all the answers

What is the sequence of events in a T cell dependent B cell response?

Antigen binding to BCR, CD4+ T cell recognition of antigen-MHC complex, CD80 on B-cell binding to CD28 on T cell Signup and view all the answers

Which type of peptides are recognized by CD8+ T cells?

Endogenous peptides Signup and view all the answers

What is the main function of CD8+ T cells?

Recognize and kill both infected and tumor cells Signup and view all the answers

Which type of cells present antigens on MHC class II molecules?

CD4+ T cells Signup and view all the answers

What is the role of MHC class II molecules?

Recognize exogenous peptides Signup and view all the answers

How are exogenous antigens processed in the cell?

Through the lysosome Signup and view all the answers

Which type of cells recognize MHC class I molecules?

T cells Signup and view all the answers

What is the function of MHC class II molecules?

Present peptides from exogenous proteins Signup and view all the answers

Why do T cells need antigen presenting cells?

To receive antigens in the context of MHC molecules Signup and view all the answers

Which type of antigens can B cells recognize?

Native or unprocessed antigens Signup and view all the answers

What is the main difference between B cells and T cells in recognizing antigens?

B cells recognize native antigens, while T cells require antigen presentation Signup and view all the answers

What is the cellular compartment where MHC Class I molecules load peptides?

Endoplasmic reticulum Signup and view all the answers

Which accessory proteins are involved in peptide loading of MHC Class II molecules?

CD40 ligand Signup and view all the answers

What is the fate of a B cell after it becomes an experienced antigen?

It becomes a plasma cell Signup and view all the answers

What is the main function of plasma cells?

They produce antibodies Signup and view all the answers

Which type of T cells recognize antigens presented on MHC Class II molecules?

CD4+ T helper cells Signup and view all the answers

What is the function of lysosomes in antigen processing and presentation?

They break down proteins into peptides Signup and view all the answers

Where do MHC class II molecules encounter antigens?

In the phagosome Signup and view all the answers

What prevents endogenous peptides from binding to MHC class II molecules in the endoplasmic reticulum?

The presence of clip peptides Signup and view all the answers

Where are MHC class II molecules loaded with peptides?

In the endosome Signup and view all the answers

How do viruses evade MHC class II antigen presentation?

By reducing MHC class II processing Signup and view all the answers

What is the role of antigen presenting cells in the immune response?

To present antigens to T cells Signup and view all the answers

Which cells can act as antigen presenting cells?

Dendritic cells, macrophages, and B cells Signup and view all the answers

What is the main difference between MHC Class I and MHC Class II molecules?

MHC Class I presents antigens from within the cell, while MHC Class II presents antigens from outside the cell Signup and view all the answers

What is the function of TAP proteins in antigen processing?

To transport antigens from the cytoplasm to the plasma reticulum Signup and view all the answers

What is the significance of the turnover of proteins inside a cell?

It ensures a constant supply of antigens for presentation Signup and view all the answers

Which type of peptides are presented on MHC Class II molecules?

Peptides from exogenous proteins Signup and view all the answers

What is the main difference between MHC Class I and MHC Class II molecules?

MHC Class I is expressed on antigen-presenting cells, while MHC Class II is expressed on all cells Signup and view all the answers

What is the role of MHC Class I molecules in antigen presentation?

To present peptides from endogenous proteins to CD8+ T cells Signup and view all the answers

What is the purpose of antigen processing and presentation?

To activate CD8+ T cells and kill infected cells Signup and view all the answers

What happens to MHC Class II molecules after they present peptides to CD4+ T cells?

They are recycled back to the cell surface Signup and view all the answers

Which enzyme is responsible for the genetic recombination of variable, diversity, and joining regions in B cells and T cells?

RAG-1 and RAG-2 Signup and view all the answers

What is the process called that refines B cell receptor recognition of antigen?

Somatic hypermutation Signup and view all the answers

What is the last step in a B cell's response to antigen, which replaces the constant region of the antibody?

Class switch recombination Signup and view all the answers

Which pathway is responsible for processing exogenous antigens, such as pathogens?

Exogenous antigen presentation pathway Signup and view all the answers

Which cellular compartment is responsible for breaking down exogenous antigens into peptides?

Phagolysosome Signup and view all the answers

Which type of T cells recognize MHC class II complexed peptides?

CD4+ T cells Signup and view all the answers

Which type of T cells recognize MHC class I complexed peptides?

CD8+ T cells Signup and view all the answers

What is the main function of CD40L on T cells and CD40 on B cells?

Provides a second activation signal Signup and view all the answers

Which type of cells present antigens on MHC class II molecules?

Antigen presenting cells Signup and view all the answers

What is the purpose of antigen processing and presentation?

To generate an immune response Signup and view all the answers

Which cells express CD3 and either CD4 or CD8?

T cells Signup and view all the answers

Where do B cells and T cells develop?

Bone marrow Signup and view all the answers

What is the purpose of positive selection in B cells and T cells?

Promotes survival Signup and view all the answers

How do B cells and T cells generate an immune response?

B cells recognize native antigen, T cells recognize processed peptides Signup and view all the answers

Which type of T cells recognize MHC class II molecules?

CD4+ T cells Signup and view all the answers

How do B cells take up antigen?

Through specific binding to their B cell receptor Signup and view all the answers

Which cells are capable of recognizing a large range of pathogens via pattern recognition receptors?

Macrophages Signup and view all the answers

Which type of cells undergo positive and negative selection?

T cells Signup and view all the answers

Which type of cells need antigen to be processed into peptides and presented in the context of MHC molecules?

T cells Signup and view all the answers

Which type of cells express CD19 and CD20?

B cells Signup and view all the answers

T1 L6: Adaptive immunity 3 (CP)

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Questions and Answers

Which cells present peptides from endogenous proteins?

What type of cells recognize MHC class II?

Why do T cells need to work with antigen presenting cells?

What is the main difference between B cells and T cells in recognizing antigens?

What type of peptides does MHC class II present?

What cells need to be able to distinguish between external and internal antigens?

What is the purpose of antigen processing and presentation?

Which cells recognize MHC class I?

What is the email address of Chris Pepper?

What is the learning outcome of the lecture?

Which type of antigen is presented on Class I MHC molecules to CD8+ T cells?

Which cellular compartment is responsible for the generation of Class I MHC peptides?

What is the role of TAP proteins in antigen processing?

Which type of antigens activate cytotoxic CD8+ T cells for killing infected cells and tumor cells?

Which viral protein can selectively bind to TAP and inhibit the transfer of peptides into the ER?

Which pathway is responsible for generating peptides bound to MHC Class II molecules?

What prevents MHC Class II from binding self peptides in the ER?

Which type of antigens activate CD4+ T cells?

Which viral protein reduces MHC Class II processing and inhibits the production of invariant chain peptide?

What is the sequence of events in a T cell dependent B cell response?

Which type of peptides are recognized by CD8+ T cells?

What is the main function of CD8+ T cells?

Which type of cells present antigens on MHC class II molecules?

What is the role of MHC class II molecules?

How are exogenous antigens processed in the cell?

Which type of cells recognize MHC class I molecules?

What is the function of MHC class II molecules?

Why do T cells need antigen presenting cells?

Which type of antigens can B cells recognize?

What is the main difference between B cells and T cells in recognizing antigens?

What is the cellular compartment where MHC Class I molecules load peptides?

Which accessory proteins are involved in peptide loading of MHC Class II molecules?

What is the fate of a B cell after it becomes an experienced antigen?

What is the main function of plasma cells?

Which type of T cells recognize antigens presented on MHC Class II molecules?

What is the function of lysosomes in antigen processing and presentation?

Where do MHC class II molecules encounter antigens?

What prevents endogenous peptides from binding to MHC class II molecules in the endoplasmic reticulum?

Where are MHC class II molecules loaded with peptides?

How do viruses evade MHC class II antigen presentation?

What is the role of antigen presenting cells in the immune response?

Which cells can act as antigen presenting cells?

What is the main difference between MHC Class I and MHC Class II molecules?

What is the function of TAP proteins in antigen processing?

What is the significance of the turnover of proteins inside a cell?

Which type of peptides are presented on MHC Class II molecules?

What is the main difference between MHC Class I and MHC Class II molecules?

What is the role of MHC Class I molecules in antigen presentation?

What is the purpose of antigen processing and presentation?

What happens to MHC Class II molecules after they present peptides to CD4+ T cells?

Which enzyme is responsible for the genetic recombination of variable, diversity, and joining regions in B cells and T cells?

What is the process called that refines B cell receptor recognition of antigen?

What is the last step in a B cell's response to antigen, which replaces the constant region of the antibody?

Which pathway is responsible for processing exogenous antigens, such as pathogens?

Which cellular compartment is responsible for breaking down exogenous antigens into peptides?

Which type of T cells recognize MHC class II complexed peptides?

Which type of T cells recognize MHC class I complexed peptides?

What is the main function of CD40L on T cells and CD40 on B cells?

Which type of cells present antigens on MHC class II molecules?

What is the purpose of antigen processing and presentation?

Which cells express CD3 and either CD4 or CD8?

Where do B cells and T cells develop?

What is the purpose of positive selection in B cells and T cells?

How do B cells and T cells generate an immune response?

Which type of T cells recognize MHC class II molecules?

How do B cells take up antigen?

Which cells are capable of recognizing a large range of pathogens via pattern recognition receptors?

Which type of cells undergo positive and negative selection?

Which type of cells need antigen to be processed into peptides and presented in the context of MHC molecules?

Which type of cells express CD19 and CD20?

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