18 Questions
What is the main mechanism of action of tetracyclines?
Inhibit bacterial protein synthesis by binding to the 30S ribosome
Which metallic ions do tetracyclines bind to form insoluble complexes?
Calcium, magnesium, and aluminum
Against which types of organisms are tetracyclines effective?
Gram negative, gram positive, protozoans
What is the most common drug in the tetracycline class?
Doxycycline (Doryx)
What are the indications for using tetracyclines?
Skin/Acne, GI/GU infections, Respiratory infections, Tick/bug infections
What is a significant adverse effect of tetracyclines related to calcium?
Discoloration of permanent teeth and tooth enamel in fetuses and children
What is the main mechanism of action of tetracyclines?
Inhibit bacterial protein synthesis by binding to the 30S ribosome
What is a significant adverse effect of tetracyclines related to calcium?
Discoloration of permanent teeth and tooth enamel in fetuses and children
What should be avoided while taking tetracyclines due to chelation and drug-binding that occurs?
Milk products, iron preparations, antacids, and other dairy products
Which infections are indicated for the use of tetracyclines?
Skin/Acne, GI/GU infections, Respiratory infections, Tick/bug infections
What alteration in intestinal flora may result from taking tetracyclines?
Superinfection (overgrowth of nonsusceptible organisms such as Candida)
What is a nursing implication related to tetracyclines and sunlight exposure?
Avoid sunlight and tanning beds due to photosensitivity
What is the most common indication for using doxycycline (Vibramycin)?
Skin/Acne
What is the significant adverse effect of tetracyclines related to calcium in fetuses, children, or nursing infants?
Discoloration of permanent teeth and tooth enamel
Which metallic ions do tetracyclines bind to form insoluble complexes?
Calcium and magnesium
What alteration in intestinal flora may result from taking tetracyclines?
Overgrowth of nonsusceptible organisms such as Candida
What is the nursing implication related to tetracyclines and sunlight exposure?
Warn against sunlight and tanning bed exposure
Against which types of organisms are tetracyclines effective?
Both gram-negative and gram-positive
Study Notes
Mechanism of Action and Pharmacology
- Tetracyclines work by inhibiting protein synthesis in bacteria.
- They bind to metallic ions, such as calcium, magnesium, and iron, to form insoluble complexes.
- This binding leads to chelation and drug-binding, which can affect absorption and efficacy.
Spectrum of Activity
- Tetracyclines are effective against a wide range of bacteria, including Gram-positive and Gram-negative bacteria, as well as some protozoa and rickettsiae.
Indications and Uses
- The most common drug in the tetracycline class is doxycycline (Vibramycin).
- Tetracyclines are indicated for treating a variety of infections, including urinary tract infections, respiratory tract infections, and sexually transmitted infections.
- Doxycycline is commonly used to treat acne, rosacea, and Lyme disease.
Adverse Effects
- A significant adverse effect of tetracyclines is related to calcium, as they can bind to calcium and lead to skeletal and dental deformities in fetuses, children, and nursing infants.
- Tetracyclines can also cause superinfections, which can lead to alterations in intestinal flora.
- Patients taking tetracyclines should avoid taking antacids, calcium supplements, and iron preparations, as they can reduce the absorption of the antibiotic.
Nursing Implications
- Tetracyclines can increase the risk of photosensitivity, so patients should avoid sunlight exposure and use sunscreen and protective clothing.
- Nurses should monitor patients for signs of superinfection, such as diarrhea or vaginal itching, and report any changes to the healthcare provider.
Test your knowledge of tetracyclines and their properties with this quiz. Explore their mechanism of action, interactions with metallic ions, and effectiveness against different types of bacteria and protozoans. This quiz also covers common drugs like doxycycline and their indications for use in medical conditions such as skin/acne, GI/GU infections, and respiratory infections.
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