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Questions and Answers
What is the main mechanism of action of tetracyclines?
What is the main mechanism of action of tetracyclines?
- Inhibit bacterial cell wall synthesis
- Inhibit folic acid synthesis
- Inhibit DNA gyrase
- Inhibit bacterial protein synthesis by binding to the 30S ribosome (correct)
Which metallic ions do tetracyclines bind to form insoluble complexes?
Which metallic ions do tetracyclines bind to form insoluble complexes?
- Sodium, potassium, and iron
- Lead, mercury, and cadmium
- Zinc, copper, and nickel
- Calcium, magnesium, and aluminum (correct)
Against which types of organisms are tetracyclines effective?
Against which types of organisms are tetracyclines effective?
- Virus, fungi, helminths
- Gram negative, helminths, fungi
- Gram negative, gram positive, protozoans (correct)
- Gram positive, virus, protozoans
What is the most common drug in the tetracycline class?
What is the most common drug in the tetracycline class?
What are the indications for using tetracyclines?
What are the indications for using tetracyclines?
What is a significant adverse effect of tetracyclines related to calcium?
What is a significant adverse effect of tetracyclines related to calcium?
What is the main mechanism of action of tetracyclines?
What is the main mechanism of action of tetracyclines?
What is a significant adverse effect of tetracyclines related to calcium?
What is a significant adverse effect of tetracyclines related to calcium?
What should be avoided while taking tetracyclines due to chelation and drug-binding that occurs?
What should be avoided while taking tetracyclines due to chelation and drug-binding that occurs?
Which infections are indicated for the use of tetracyclines?
Which infections are indicated for the use of tetracyclines?
What alteration in intestinal flora may result from taking tetracyclines?
What alteration in intestinal flora may result from taking tetracyclines?
What is a nursing implication related to tetracyclines and sunlight exposure?
What is a nursing implication related to tetracyclines and sunlight exposure?
What is the most common indication for using doxycycline (Vibramycin)?
What is the most common indication for using doxycycline (Vibramycin)?
What is the significant adverse effect of tetracyclines related to calcium in fetuses, children, or nursing infants?
What is the significant adverse effect of tetracyclines related to calcium in fetuses, children, or nursing infants?
Which metallic ions do tetracyclines bind to form insoluble complexes?
Which metallic ions do tetracyclines bind to form insoluble complexes?
What alteration in intestinal flora may result from taking tetracyclines?
What alteration in intestinal flora may result from taking tetracyclines?
What is the nursing implication related to tetracyclines and sunlight exposure?
What is the nursing implication related to tetracyclines and sunlight exposure?
Against which types of organisms are tetracyclines effective?
Against which types of organisms are tetracyclines effective?
Flashcards
Tetracyclines: Action
Tetracyclines: Action
Inhibit bacterial protein synthesis by binding to the 30S ribosome.
Tetracycline Binding
Tetracycline Binding
Calcium, magnesium, and aluminum.
Tetracycline Target
Tetracycline Target
Effective against gram-negative, gram-positive, and protozoans.
Common Tetracycline
Common Tetracycline
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Tetracycline Use
Tetracycline Use
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Tetracycline & Teeth
Tetracycline & Teeth
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Tetracycline Avoid
Tetracycline Avoid
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Tetracycline Flora
Tetracycline Flora
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Tetracycline & Sun
Tetracycline & Sun
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Doxycycline Use
Doxycycline Use
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Tetracycline: Child Risk
Tetracycline: Child Risk
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Tetracycline Ion Bind
Tetracycline Ion Bind
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Tetracycline Patient Advice
Tetracycline Patient Advice
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Tetracycline Coverage
Tetracycline Coverage
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Tetracycline MOA
Tetracycline MOA
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Tetracycline Adverse Effect
Tetracycline Adverse Effect
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Tetracycline Interaction
Tetracycline Interaction
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Tetracycline Targets
Tetracycline Targets
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Study Notes
Mechanism of Action and Pharmacology
- Tetracyclines work by inhibiting protein synthesis in bacteria.
- They bind to metallic ions, such as calcium, magnesium, and iron, to form insoluble complexes.
- This binding leads to chelation and drug-binding, which can affect absorption and efficacy.
Spectrum of Activity
- Tetracyclines are effective against a wide range of bacteria, including Gram-positive and Gram-negative bacteria, as well as some protozoa and rickettsiae.
Indications and Uses
- The most common drug in the tetracycline class is doxycycline (Vibramycin).
- Tetracyclines are indicated for treating a variety of infections, including urinary tract infections, respiratory tract infections, and sexually transmitted infections.
- Doxycycline is commonly used to treat acne, rosacea, and Lyme disease.
Adverse Effects
- A significant adverse effect of tetracyclines is related to calcium, as they can bind to calcium and lead to skeletal and dental deformities in fetuses, children, and nursing infants.
- Tetracyclines can also cause superinfections, which can lead to alterations in intestinal flora.
- Patients taking tetracyclines should avoid taking antacids, calcium supplements, and iron preparations, as they can reduce the absorption of the antibiotic.
Nursing Implications
- Tetracyclines can increase the risk of photosensitivity, so patients should avoid sunlight exposure and use sunscreen and protective clothing.
- Nurses should monitor patients for signs of superinfection, such as diarrhea or vaginal itching, and report any changes to the healthcare provider.
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Description
Test your knowledge of tetracyclines and their properties with this quiz. Explore their mechanism of action, interactions with metallic ions, and effectiveness against different types of bacteria and protozoans. This quiz also covers common drugs like doxycycline and their indications for use in medical conditions such as skin/acne, GI/GU infections, and respiratory infections.
