Tetracyclines Quiz
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Questions and Answers

What is the mechanism of action of tetracyclines?

  • They inhibit protein synthesis (correct)
  • They inhibit cell wall synthesis
  • They inhibit RNA transcription
  • They inhibit DNA replication

What is the main function of tetracyclines?

  • Inhibit DNA synthesis
  • Inhibit RNA synthesis
  • Inhibit cell wall synthesis
  • Inhibit protein synthesis (correct)

What type of bacteria are tetracyclines active against?

  • Only gram-negative bacteria
  • Only gram-positive bacteria
  • Fungi and viruses
  • Gram-positive and gram-negative bacteria (correct)

What type of bacteria are tetracyclines active against?

<p>Both gram-positive and gram-negative bacteria (A)</p> Signup and view all the answers

How many mechanisms of resistance to tetracycline analogs are there?

<p>Three (B)</p> Signup and view all the answers

How many mechanisms of resistance to tetracycline analogs are there?

<p>Three (A)</p> Signup and view all the answers

What is the difference between tetracyclines in terms of their absorption and elimination?

<p>They differ in their absorption after oral administration and in their elimination (C)</p> Signup and view all the answers

In which body fluids are tetracyclines not distributed widely?

<p>Cerebrospinal fluid (B)</p> Signup and view all the answers

Where are tetracyclines distributed in the body?

<p>Widely to tissues and body fluids except for cerebrospinal fluid (B)</p> Signup and view all the answers

Where are tetracyclines excreted mainly?

<p>Bile (C)</p> Signup and view all the answers

How are tetracyclines excreted from the body?

<p>Mainly in bile and urine (D)</p> Signup and view all the answers

How are tetracyclines classified?

<p>As short-acting, intermediate-acting, or long-acting (D)</p> Signup and view all the answers

How are tetracyclines classified?

<p>Short-acting, intermediate-acting, or long-acting (D)</p> Signup and view all the answers

What is a potential side effect of tetracyclines?

<p>Damage to growing bones and teeth (B)</p> Signup and view all the answers

Flashcards

Tetracycline action

Inhibit bacterial protein synthesis.

Main tetracycline function

Inhibition of protein synthesis.

Tetracycline target

Both Gram-positive and Gram-negative bacteria.

Resistance mechanisms

Three

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Tetracycline differences

Absorption (oral) and elimination.

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Poor tetracycline fluid distribution

Cerebrospinal fluid

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Tetracycline distribution

Widely distributed, except cerebrospinal fluid

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Main tetracycline excretion

Bile

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Tetracycline excretion route

Bile and urine.

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Tetracycline classification

Short, intermediate, or long-acting.

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Tetracycline side effect

Damage to growing bones and teeth.

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Tetracycline: Bacteriostatic or Bactericidal?

Primarily bacteriostatic, inhibiting bacterial protein synthesis, but at high concentrations some may be bactericidal.

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Tetracycline MOA in detail

Inhibits binding of aminoacyl-tRNA to the A site on the bacterial ribosome

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Tetracycline transport

Transport of tetracyclines across the inner cytoplasmic membrane is energy dependent

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Study Notes

  • Tetracyclines are antibiotics that inhibit protein synthesis.
  • They are active against many gram-positive and gram-negative bacteria.
  • There are three mechanisms of resistance to tetracycline analogs.
  • Tetracyclines differ in their absorption after oral administration and in their elimination.
  • Tetracyclines are 40–80% bound by serum proteins.
  • Tetracyclines are distributed widely to tissues and body fluids except for cerebrospinal fluid.
  • They cross the placenta to reach the fetus and are excreted in milk.
  • Tetracyclines are excreted mainly in bile and urine.
  • Tetracyclines are classified as short-acting, intermediate-acting, or long-acting.
  • Tetracyclines can damage growing bones and teeth.

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Description

Think you know everything there is to know about tetracyclines? Test your knowledge with our quiz! From their mechanisms of resistance to their absorption and elimination, this quiz will cover all the key facts about tetracyclines. Plus, we'll dive into the different classifications of tetracyclines and the potential risks associated with their use. Perfect for students, healthcare professionals, and anyone interested in antibiotics and their effects on the body.

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