Tests for Efficacy and Defects of Innate Immunity
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Questions and Answers

Which type of cells secrete fatty acids and defensins in sweat as part of the first line of defense?

  • Macrophages
  • Dendritic cells
  • Neutrophils
  • Epithelial cells (correct)

What is the function of surfactants secreted by type II pneumocytes in the respiratory tract as a part of the first line of defense?

  • Secrete antimicrobial peptides
  • Lubricate the alveoli (correct)
  • Bind pathogens for phagocytosis
  • Promote cough-sneeze reflex

Which of the following is a component of the first line of defense in the gastrointestinal tract due to its role in secreting antimicrobial peptides?

  • Epithelium
  • Paneth cells (correct)
  • Resident bacteria
  • Stomach acidity

What is the main function of Tamm-Horsfall protein (THP) in the genitourinary tract as a part of the first line of defense?

<p>Promote urine acidity (B)</p> Signup and view all the answers

What is the primary function of the body's first line of defense?

<p>Preventing pathogens from entering the body (B)</p> Signup and view all the answers

Which of the following is a non-cellular component of the innate immune system?

<p>Mucus membranes (B)</p> Signup and view all the answers

What is the main principle involved in pathogen recognition by innate cells?

<p>Pattern recognition (D)</p> Signup and view all the answers

How does the innate immune system affect the adaptive immune system?

<p>By initiating and modulating adaptive immune responses (A)</p> Signup and view all the answers

Which type of interferons is primarily involved in antiviral defense?

<p>IFN-α (B)</p> Signup and view all the answers

Which type of interferon is also involved in defenses against intracellular pathogens, but is associated more with cellular immunity?

<p>IFN- (A)</p> Signup and view all the answers

Which cardinal sign is associated with increased blood flow and erythema?

<p>Redness – Rubor (C)</p> Signup and view all the answers

What does NBT (Nitro Blue Tetrazolium) measure in phagocytes?

<p>Killing capacity by ROS (B)</p> Signup and view all the answers

Which type of cells express CD56, but not TCR, and are a special type of T cells?

<p>Natural Killer Cells (D)</p> Signup and view all the answers

What is the primary function of type III interferons?

<p>Not mentioned in the text (D)</p> Signup and view all the answers

Which cellular component of innate immunity is primarily responsible for the process of phagocytosis?

<p>Neutrophils (A)</p> Signup and view all the answers

Which type of receptor found on innate cells is responsible for recognizing pathogen-associated molecular patterns (PAMPs)?

<p>Toll-like receptors (TLRs) (D)</p> Signup and view all the answers

Which major signal transduction pathway is involved in the innate immune response and activation of inflammatory genes?

<p>NF-κB pathway (A)</p> Signup and view all the answers

Which specific type of enzyme is involved in the intracellular killing by phagocytes?

<p>Myeloperoxidase (C)</p> Signup and view all the answers

Which cellular component of innate immunity is primarily responsible for secreting proinflammatory cytokines to recruit other immune cells to the site of infection?

<p>Mast cells (C)</p> Signup and view all the answers

Which type of interferons are primarily involved in antiviral defense?

<p>IFN- (C)</p> Signup and view all the answers

What is the main function of natural killer (NK) cells?

<p>Activation of NK cells (C)</p> Signup and view all the answers

What is the role of type III interferons in the immune system?

<p>Inhibition of viral replication (A)</p> Signup and view all the answers

Which cells express CD56, but not T-cell receptor, and are a special type of T cells?

<p>Natural Killer Cells (A)</p> Signup and view all the answers

Which type of interferon is associated more with cellular immunity and defenses against intracellular pathogens?

<p>IFN- (C)</p> Signup and view all the answers

Which receptor is activated by IL-12, IFN-, TNF-, IL-15, and possesses Fc receptor FcRIII (CD16) for Antibody Dependent Cellular Cytotoxicity (ADCC)?

<p>KAR (Killer Activation Receptor) (C)</p> Signup and view all the answers

Which cell is involved in NK Cell - Adaptive Killing Function and possesses the inducible expression of FasL and releases perforin/granzyme?

<p>NK Cell (C)</p> Signup and view all the answers

What is the primary function of Apoptosis in immunity?

<p>To induce cell death in self-reactive lymphocytes (A)</p> Signup and view all the answers

Which process leads to the activation of Fas+ target cells and eventually results in Cell Death via Fas/FasL Apoptosis?

<p>Binding of FasL to Fas on target cells (B)</p> Signup and view all the answers

What is the role of FasL in inducing cell death?

<p>Inducing apoptosis in Fas-expressing cells (A)</p> Signup and view all the answers

Which type of cells are responsible for secreting fatty acids and defensins in sweat as part of the first line of defense?

<p>Epithelial cells (C)</p> Signup and view all the answers

Which type of cells are known for their rapid response and non-specific receptors encoded in the germ line?

<p>Neutrophils (C)</p> Signup and view all the answers

Which type of cells are responsible for antigen presentation and are part of the first line of defense in the skin?

<p>Dendritic cells (C)</p> Signup and view all the answers

Which type of cells are involved in the flushing action of urine as part of the first line of defense in the genitourinary tract?

<p>Epithelial cells (A)</p> Signup and view all the answers

Which type of cells are known for their ability to secrete TNF-α and IL-8 as part of the innate immune response?

<p>Neutrophils (C)</p> Signup and view all the answers

Which of the following is a protein secreted by Paneth cells in the gastrointestinal tract as a part of the first line of defense?

<p>Lysozyme (C)</p> Signup and view all the answers

Which protein is primarily involved in the lubrication of alveoli and binding of pathogens for phagocytosis in the respiratory tract?

<p>Surfactant (A)</p> Signup and view all the answers

Which protein is known for its antimicrobial and immunomodulatory functions in the genitourinary tract?

<p>Tamm-Horsfall protein (THP) (D)</p> Signup and view all the answers

Which protein is secreted by sweat glands as part of the first line of defense?

<p>Defensins (D)</p> Signup and view all the answers

What type of proteins are predominantly secreted by Paneth cells in the gastrointestinal tract as a part of innate immunity?

<p>Antimicrobial peptides (A)</p> Signup and view all the answers

Which type of interferon is primarily involved in antiviral defense?

<p>IFN- (D)</p> Signup and view all the answers

What is the function of C-reactive protein as part of the innate immune system?

<p>Detection of pathogens and initiation of the complement cascade (B)</p> Signup and view all the answers

Which type of cells secrete defensins as part of the first line of defense?

<p>Type II pneumocytes (D)</p> Signup and view all the answers

What is the primary role of acute phase proteins in the innate immune system?

<p>Detection of pathogens and initiation of the complement cascade (C)</p> Signup and view all the answers

What is measured by NBT (Nitro Blue Tetrazolium) in phagocytes?

<p>Killing capacity by ROS (C)</p> Signup and view all the answers

Which cellular component of innate immunity is primarily responsible for secreting antimicrobial peptides?

<p>Keratinocytes (C)</p> Signup and view all the answers

What is the primary function of defensins secreted by various cells in innate immunity?

<p>Inhibiting viral replication (B)</p> Signup and view all the answers

Which enzyme is involved in the process of intracellular killing by phagocytes?

<p>Myeloperoxidase (C)</p> Signup and view all the answers

Which specific non-cellular component plays a role in preventing pathogens from binding to host cell receptors?

<p>Mannose-binding lectin (B)</p> Signup and view all the answers

Which protein plays a role in opsonization and subsequent phagocytosis of pathogens?

<p>Lactoferrin (A)</p> Signup and view all the answers

Which protein is secreted by type II pneumocytes in the respiratory tract as part of the first line of defense?

<p>Surfactant protein A (C)</p> Signup and view all the answers

Which non-enzymatic protein contributes to the protection of mucosal surfaces in the gastrointestinal tract?

<p>Mucin (A)</p> Signup and view all the answers

Which protein functions by binding iron ions and thereby inhibiting bacterial growth?

<p>Lactoferrin (B)</p> Signup and view all the answers

Which non-enzymatic protein contributes to the regulation of the complement system and phagocytosis?

<p>Mannose-binding lectin (C)</p> Signup and view all the answers

Which protein contributes to the process of opsonization and phagocytosis and also has antimicrobial properties?

<p>Cathelicidin (B)</p> Signup and view all the answers

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