Innate vs. Adaptive Immunity Quiz

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Questions and Answers

What is the primary function of cytotoxic T-cells?

  • To produce antibodies against pathogens
  • To secrete proteins that assist other immune cells
  • To recognize and kill virus-infected cells (correct)
  • To deactivate the immune response

Where do T-cells mature in the body?

  • The bone marrow
  • The spleen
  • The thymus (correct)
  • The liver

What is the role of helper T-cells in the immune system?

  • To inhibit the production of antibodies
  • To enhance the activity of other immune cells (correct)
  • To directly kill infected cells
  • To create memory cells for future infections

Which type of T-cell is primarily responsible for controlling the immune response?

<p>Regulatory T-cells (C)</p> Signup and view all the answers

Which antibody is primarily responsible for immune protection to the fetus and newborn?

<p>IgG (C)</p> Signup and view all the answers

What is the function of major histocompatibility complex (MHC) molecules?

<p>Recognize antigens in the context of self-molecules (C)</p> Signup and view all the answers

What is the main role of IgA in the immune system?

<p>Prevention of pathogens from crossing the epithelium (D)</p> Signup and view all the answers

Which antibody is most associated with allergic reactions?

<p>IgE (D)</p> Signup and view all the answers

What type of immune response is primarily mediated by T-cells?

<p>Cell-mediated response (D)</p> Signup and view all the answers

What characterizes the role of IgD in the immune response?

<p>Receptor that binds antigens on B cells (D)</p> Signup and view all the answers

Which antibody is considered the major antibody produced in response to an initial exposure to an antigen?

<p>IgG (C)</p> Signup and view all the answers

What is a key function of mast cells activated by IgE?

<p>Histamine release (C)</p> Signup and view all the answers

How do T-cells contribute to the cell-mediated immune response?

<p>By directly attacking infected host cells (A)</p> Signup and view all the answers

What is the primary role of barrier defenses in the immune system?

<p>To prevent pathogens and chemicals from entering the body (A)</p> Signup and view all the answers

Which cells are primarily responsible for antibody production in the humoral immune response?

<p>B-cells (A)</p> Signup and view all the answers

What characterizes inflammation in the immune response?

<p>Fever, redness, swelling, pain, and loss of function (D)</p> Signup and view all the answers

What is a foreign antigen?

<p>A pathogen or substance introduced from outside the body (A)</p> Signup and view all the answers

Which type of antibody is the first to appear during an immune response?

<p>IgM (C)</p> Signup and view all the answers

What is one of the roles of the complement system in the immune response?

<p>To promote the endocytosis of pathogens by cells like macrophages (C)</p> Signup and view all the answers

How do B-cells become activated?

<p>Upon encountering an antigen in the lymph nodes (A)</p> Signup and view all the answers

Which of the following describes the function of phagocytic cells?

<p>To destroy pathogens through ingestion (A)</p> Signup and view all the answers

What is a key characteristic of innate immunity?

<p>It provides a fast-acting defense against infections. (B)</p> Signup and view all the answers

How does adaptive immunity differ from innate immunity?

<p>It can recognize and remember specific pathogens for faster response on re-exposure. (C)</p> Signup and view all the answers

What role does the innate immune system play in the overall immune response?

<p>It enhances the adaptive immune response by signaling threats. (C)</p> Signup and view all the answers

Why might a person get sick despite following healthy precautions?

<p>Pathogens may still evade the immune system. (C)</p> Signup and view all the answers

Which of the following statements about adaptive immunity is true?

<p>It relies on memory cells to respond more effectively to subsequent infections. (D)</p> Signup and view all the answers

What is the primary function of signaling from the innate immune system?

<p>To alert the adaptive immune system to threats. (B)</p> Signup and view all the answers

What could be the consequence of not having memory cells in adaptive immunity?

<p>Infections could be more severe upon re-exposure to the same pathogens. (D)</p> Signup and view all the answers

Flashcards

Innate Immunity

The body's fast-acting, first line of defense against pathogens. It's non-specific and doesn't adapt or remember previous encounters.

Adaptive Immunity

A slower-acting immune response that develops after exposure. It is highly specific to particular pathogens and has memory, enabling quicker responses upon re-exposure.

Pathogen

A microorganism or substance that causes disease.

Immunity

The ability of an organism to resist a particular infection or disease.

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Specific Features of Adaptive Immunity

Features enabling the recognition and targeting of specific pathogens, and remembering previous encounters.

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Memory Features of Adaptive Immunity

The ability of the immune system to remember past encounters with a pathogen, leading to a faster response upon re-exposure.

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Internal threats (immunity)

Harmful substances or cells within the body, such as cancer cells.

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Innate Immune System's Role

Providing an initial signal to the rest of the immune system to tackle threats in the body.

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Barrier Defenses

The body's first line of defense against pathogens, preventing them from entering. It includes physical barriers like skin and mucous membranes, and secretions like tears and saliva.

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Internal Defenses

The body's second line of defense, which acts when pathogens get past the barriers. It involves chemical mediators, white blood cells, and the inflammatory response.

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What are Chemical Mediators?

Substances that fight infections and help recruit immune cells. Examples include interferons and complement proteins.

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Phagocytic Cells

White blood cells that engulf and destroy pathogens by eating them.

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Natural Killer Cells

White blood cells that destroy infected cells or cancer cells.

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Inflammation: What is it?

A localized response to injury or infection characterized by redness, swelling, heat, pain and sometimes loss of function.

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What are Antibodies?

Proteins produced by the immune system to bind specifically to antigens, helping neutralize pathogens.

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IgG

The primary antibody produced by the immune system. It plays a crucial role in neutralizing pathogens like viruses and bacteria, protecting the body from infection. IgG also provides immune protection to the fetus and newborn through maternal antibodies.

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IgA

The key antibody in the mucosal immune system, found in secretions such as saliva, tears, and breast milk. It acts as a barrier, preventing pathogens from entering the bloodstream.

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IgE

An antibody primarily associated with allergic reactions. It binds to mast cells, which release histamine, a chemical that triggers inflammation and allergy symptoms.

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IgD

An antibody primarily found on the surface of B cells. It acts as an antigen-binding receptor, helping B cells recognize and bind to specific pathogens.

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Cell-mediated immunity

A type of immune response that occurs within the cells. It focuses on eliminating intracellular pathogens like viruses, which are not easily accessible to antibodies.

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What are cytotoxic cells?

Cytotoxic cells are specialized immune cells, such as T lymphocytes, that destroy infected or cancerous cells directly. They play a key role in cell-mediated immunity.

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Why is cell-mediated immunity important?

Cell-mediated immunity is crucial for tackling pathogens that live inside cells, such as viruses, where antibodies might not be able to reach them.

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What is the role of T cells?

T cells are a type of white blood cell that are crucial for cell-mediated immunity. They recognize and eliminate infected or damaged cells, helping control viral infections and preventing tumor growth.

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T-cells

White blood cells that mature in the thymus, recognize antigens with help from MHC molecules, and have different types with specialized roles in the immune response.

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MHC molecules

Glycoproteins on cells that present antigens to T-cells, helping them recognize invaders in the context of 'self.'

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Cytotoxic T-cells

T-cells that directly kill virus-infected cells, preventing the virus from spreading further.

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Helper T-cells

T-cells that help other immune cells, like B cells, macrophages, and other T-cells, perform their functions by secreting proteins.

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Regulatory T-cells

T-cells that control the immune response by turning it off, preventing the immune system from attacking healthy cells.

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Study Notes

Innate vs. Adaptive Immunity

  • Innate immunity is a fast-acting, non-specific defense mechanism.
  • It's the body's first response to infection.
  • Innate responses do not change with repeated exposures.
  • Innate immunity involves barrier defenses (skin, mucous membranes), internal defenses (antimicrobial proteins, phagocytic cells, inflammatory response).
  • Adaptive immunity is slower but more specific, responding to specific pathogens.
  • Adaptive immunity has memory to allow faster responses upon re-exposure to the same pathogen.

Immune System Components

  • Innate Immunity:
    • Barrier defenses (skin, mucous membranes)
    • Internal defenses (phagocytic cells, natural killer cells, antimicrobial proteins, inflammatory response)
  • Adaptive Immunity:
    • Humoral response (antibodies produced by B cells).
    • Cell-mediated response (T cells directly attacking infected cells)

Types of Cells

  • Innate Immunity:
    • Neutrophils: most abundant white blood cells, first responders
    • Eosinophils: respond to multicellular parasites
    • Basophils: release chemicals initiating inflamation
    • Monocytes: develop into macrophages and dendritic cells, slower response but longer-lasting
    • Lymphocytes: produce antibodies targeting specific antigens
  • Adaptive Immunity:
    • Cytotoxic T cells: destroy virus-infected cells
    • Helper T cells: assist other immune cells
    • Regulatory T cells: control the immune response, preventing autoimmune disease

Immune System Function

  • Innate immunity provides an initial signal to alert the rest of the immune system.
  • Pathogens and/or toxins are identified and neutralized by the immune response.
  • The adaptive response is activated.
  • Responses can be active or passive, natural or artificial.

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