Teriparatide for Osteoporosis
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Questions and Answers

A client taking teriparatide reports experiencing persistent nausea and vomiting. Which of the following actions should the nurse take first?

  • Question the client about adherence to the prescribed diet.
  • Instruct the client to take the medication at night.
  • Assess for manifestations of hypercalcemia. (correct)
  • Administer an antiemetic medication as prescribed.

Which of the following instructions should a nurse provide to a client who is starting teriparatide therapy for osteoporosis?

  • Expect a temporary decrease in bone density at the start of therapy.
  • Take the medication with an antacid to prevent stomach upset.
  • Self-inject the medication subcutaneously into the thigh or abdomen daily. (correct)
  • Administer the medication intravenously once a week.

What is the primary mechanism of action of teriparatide in treating osteoporosis?

  • Binding to estrogen receptors to mimic the effects of estrogen on bone.
  • Inhibiting osteoclast activity to reduce bone resorption.
  • Increasing calcium absorption in the small intestine.
  • Stimulating new bone formation by increasing osteoblast activity. (correct)

A client with a history of renal calculi is prescribed teriparatide. Which of the following interventions is most important for the nurse to implement?

<p>Encourage increased fluid intake to prevent hypercalcemia. (D)</p> Signup and view all the answers

A client taking digoxin also starts teriparatide therapy. The nurse should monitor for which of the following potential interactions?

<p>Increased risk of digoxin toxicity. (D)</p> Signup and view all the answers

Which of the following conditions is a contraindication for the use of teriparatide?

<p>History of osteosarcoma. (C)</p> Signup and view all the answers

A client reports experiencing orthostatic hypotension after starting teriparatide. Which of the following instructions is appropriate for the nurse to provide?

<p>Change positions slowly and avoid prolonged standing. (C)</p> Signup and view all the answers

After teaching a client about teriparatide injections, which statement by the client indicates a need for further instruction?

<p>&quot;I can continue to use the same injection pen until it is empty.&quot; (C)</p> Signup and view all the answers

Flashcards

Teriparatide: Use

Stimulates new bone formation to treat osteoporosis.

Teriparatide: Mechanism

A synthetic form of parathyroid hormone that regulates calcium homeostasis.

Teriparatide: Result

Rate of bone formation exceeds rate of bone resorption.

Teriparatide: Adverse Reactions

Hypertension, orthostatic hypotension, arthralgia, leg cramps, upper respiratory infections, angina, and hypercalcemia.

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Teriparatide: Nursing Actions

Monitor serum calcium levels before, one month after beginning, and periodically. Monitor for nausea, vomiting, and orthostatic hypotension.

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Teriparatide: Administration

20 mcg subcutaneously once daily.

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Teriparatide: Teaching

Teach subcutaneous self-injection technique. Inject into abdomen or thigh. Discard pen after 28 days.

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Teriparatide: Contraindications

History of osteosarcomas and in clients who are pregnant.

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Study Notes

Anabolic Agents - Teriparatide

  • Treats osteoporosis by stimulating new bone formation.
  • Is a synthetic form of parathyroid hormone.
  • Regulates calcium homeostasis.
  • Mediates pathways that increase the quantity and lifespan of osteoblasts.
  • Bone formation exceeds bone resorption.
  • Adverse reactions include hypertension, orthostatic hypotension, arthralgia, leg cramps, upper respiratory infections, angina, and hypercalcemia.
  • Check serum calcium level before starting treatment, again one month later, and then regularly based on individual calcium levels.
  • Watch for signs of Teriparatide toxicity, like nausea, vomiting, and orthostatic hypotension.
  • Decrease the dosage or stop treatment by prescriber if hypercalcemia continues.
  • Administration is 20 mcg subcutaneously daily.
  • Teach patients how to self-inject subcutaneously.
  • Inject into the abdomen or thigh.
  • Discard the injection pen after 28 days.
  • Do not use with clients who have a history of osteosarcomas or are pregnant.
  • Use with caution if patients have renal calculi or conditions that raise the risk of hypercalcemia.
  • Digoxin: Hypercalcemia increases the risk of digoxin toxicity.

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Description

Learn about Teriparatide, a synthetic parathyroid hormone used to treat osteoporosis by stimulating new bone formation. This medication increases osteoblast lifespan, but monitor for adverse reactions like hypertension and hypercalcemia. Proper administration and patient education on self-injection are crucial.

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