Podcast
Questions and Answers
Teriparatide increases bone formation by primarily affecting which type of bone cell?
Teriparatide increases bone formation by primarily affecting which type of bone cell?
- Chondrocytes, stimulating cartilage formation in bone joints.
- Osteoclasts, increasing their differentiation and activity.
- Osteocytes, enhancing their communication within the bone matrix.
- Osteoblasts, increasing their number and length of survival. (correct)
A client taking teriparatide reports experiencing persistent nausea and vomiting. What is the most appropriate initial nursing intervention?
A client taking teriparatide reports experiencing persistent nausea and vomiting. What is the most appropriate initial nursing intervention?
- Assess the client for other signs and symptoms of hypercalcemia. (correct)
- Reassure the client that these are common side effects and will resolve with time.
- Administer an antiemetic medication as needed for symptom relief.
- Instruct the client to increase their daily fluid intake to prevent dehydration.
Why is romosozumab use generally limited to clients who have not responded to or did not tolerate other osteoporosis medications?
Why is romosozumab use generally limited to clients who have not responded to or did not tolerate other osteoporosis medications?
- Its cost-effectiveness is lower compared to other available treatments.
- It carries a greater risk of cardiovascular events that require careful patient selection. (correct)
- It has a higher risk of causing severe allergic reactions compared to other medications.
- It requires more frequent administration, making it less convenient for most patients.
A client with a history of renal calculi is prescribed teriparatide. Which intervention is most important for the nurse to implement?
A client with a history of renal calculi is prescribed teriparatide. Which intervention is most important for the nurse to implement?
A client who is taking digoxin also begins teriparatide therapy. The nurse should closely monitor for:
A client who is taking digoxin also begins teriparatide therapy. The nurse should closely monitor for:
A client misses their daily dose of teriparatide. What instruction should the nurse provide?
A client misses their daily dose of teriparatide. What instruction should the nurse provide?
A client is prescribed teriparatide. Which pre-existing condition is a contraindication for this medication?
A client is prescribed teriparatide. Which pre-existing condition is a contraindication for this medication?
What is the primary reason for discarding a teriparatide injection pen after 28 days?
What is the primary reason for discarding a teriparatide injection pen after 28 days?
Flashcards
Anabolic Agents
Anabolic Agents
Medications that stimulate new bone formation, used to treat osteoporosis.
Teriparatide
Teriparatide
A synthetic parathyroid hormone that increases osteoblast activity and bone formation.
Parathyroid Hormone Action
Parathyroid Hormone Action
Regulates calcium levels and increases the number and survival of osteoblasts.
Common Teriparatide Side Effects
Common Teriparatide Side Effects
High blood pressure, dizziness upon standing, joint pain, leg cramps.
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Teriparatide Monitoring
Teriparatide Monitoring
Monitor serum calcium levels before and during therapy. Watch for nausea, vomiting, and hypotension.
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Teriparatide & Hypercalcemia
Teriparatide & Hypercalcemia
Mild and temporary; if persistent, dosage should be reduced or discontinued.
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Teriparatide Administration
Teriparatide Administration
Administer subcutaneously once daily into the abdomen or thigh.
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Teriparatide Contraindications
Teriparatide Contraindications
Avoid in clients with osteosarcoma history or during pregnancy; caution with renal calculi.
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- Anabolic agents treat osteoporosis by stimulating new bone formation.
- Teriparatide is the prototype anabolic agent.
- Other anabolic agents include abaloparatide and romosozumab.
- Romosozumab is for clients who haven't responded to or tolerated other medications.
Expected Pharmacologic Action
- Teriparatide is a synthetic parathyroid hormone that regulates calcium homeostasis.
- Teriparatide increases the number and survival length of osteoblasts.
- Bone formation exceeds bone resorption.
Adverse Drug Reactions
- Common adverse effects: hypertension, orthostatic hypotension, arthralgia, leg cramps, upper respiratory infections, angina, and hypercalcemia.
Interventions
- Check serum calcium levels before and one month after starting therapy.
- Monitor for nausea, vomiting, and orthostatic hypotension (signs of toxicity).
Safety Alert
- Mild, temporary hypercalcemia may occur.
- For persistent hypercalcemia, the provider should decrease dosage or discontinue medication.
Administration
- Administer 20 mcg teriparatide subcutaneously once daily.
- If a dose is missed, inject it as soon as remembered that day.
- Inject into the abdomen or thigh.
- Discard injection pen after 28 days.
Contraindications and Precautions
- Prescribe cautiously to clients with renal calculi history or conditions increasing hypercalcemia risk.
- Avoid in clients with osteosarcoma history and during pregnancy.
Interactions
- Hypercalcemia from teriparatide increases the risk of digoxin toxicity in clients taking digoxin.
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