Questions and Answers
What is the therapeutic class of Teriparatide (Forteo) Injection?
Hormone
What is one of the actions of Teriparatide (Forteo) Injection?
Regulates calcium and phosphate metabolism in bone and kidney by binding to specific cell receptors; stimulates osteoblastic activity.
Which of the following are indications for Teriparatide (Forteo) Injection? (Select all that apply)
What are the pharmacokinetics of Teriparatide regarding absorption?
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Match the following pharmacological details of Teriparatide (Forteo) Injection:
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What is a significant contraindication for Teriparatide (Forteo) Injection?
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What should patients be advised regarding the administration of Teriparatide (Forteo) Injection?
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Teriparatide (Forteo) Injection can be used safely in patients with active urolithiasis.
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What may transient hypercalcemia increase the risk of when taking Teriparatide (Forteo) Injection?
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What should patients do if light-headedness or palpitations occur after taking Teriparatide (Forteo) Injection?
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Study Notes
Teriparatide (Forteo) Injection Overview
- Teriparatide, branded as Forteo, is classified as a hormone therapy.
- It functions as an exogenous parathyroid hormone (PTH) that enhances bone formation at low doses.
Indications for Use
- Approved for treating osteoporosis in postmenopausal women at high fracture risk.
- Increases bone mass in men with primary or hypogonadal osteoporosis who are at high risk for fractures.
- Treats glucocorticoid-induced osteoporosis in both men and women who are at high risk for fractures.
- Especially beneficial for patients who have failed or are intolerant to other osteoporosis treatments.
Mechanism of Action
- Regulates calcium and phosphate metabolism by binding to specific receptors, stimulating osteoblastic activity.
- Raises serum calcium levels while lowering serum phosphorus concentrations.
- Therapeutic effects include increased bone mineral density and reduced fracture risk.
Pharmacokinetics
- Absorption: Well-absorbed via subcutaneous administration.
- Metabolism: Occurs in the liver, with renal excretion of metabolites.
- Half-life: Approximately 1 hour following subcutaneous use.
- Time/Action Profile:
- Onset: 2 hours
- Peak: 4-6 hours
- Duration: 16-24 hours
Contraindications
- Hypersensitivity reactions.
- Paget's disease or any other metabolic bone disorders.
- Unexplained elevation in alkaline phosphatase levels.
- Safety and efficacy not established for pediatric patients.
- Patients with a history of radiation therapy, bone metastases, or skeletal malignancy.
- Pre-existing hypercalcemia, pregnancy, or lactation.
Cautions and Interactions
- Caution advised for patients with active or recent urolithiasis.
- Transient hypercalcemia may elevate the risk of digoxin toxicity.
Patient Education and Administration
- Administer injections at the same time each day.
- If a dose is missed, take it as soon as remembered within the same day; do not double doses.
- Patients should be trained on proper injection technique and how to dispose of needles safely.
- Emphasize reading therapeutic guides and medication manuals prior to and during therapy.
- Discard pen devices after a 28-day usage period; sharing is prohibited.
- Additional treatment strategies for osteoporosis include supplemental calcium, vitamin D, and weight-bearing exercises.
- Patients might experience orthostatic hypotension upon initial doses; recommend lying down if light-headedness occurs.
- Persistent hypercalcemia symptoms (nausea, vomiting, constipation, muscle weakness) should be reported to healthcare providers.
- Importance of follow-up bone mineral density tests should be stressed.
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Test your knowledge on Teriparatide (Forteo) Injection with these flashcards. This quiz covers its therapeutic class, mechanism of action, and benefits in treating osteoporosis. Perfect for students and professionals in the medical field.
