Telomeres and Cell Division Quiz
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Questions and Answers

What is a telomere?

  • A type of DNA polymerase
  • A protein that aids in DNA replication
  • A type of RNA molecule
  • A region at the end of chromosomes (correct)

    • What are telomeres made of?

  • Proteins
  • Repetitive sequences of non-coding DNA (correct)
  • Repetitive sequences of coding DNA
  • Single-stranded RNA molecules

    • Why is replication at the chromosome end (telomere) always a problem in somatic cells?

  • Due to the presence of RNA primers
  • Due to the absence of telomerase
  • Due to the end replication problem in the lagging strand (correct)
  • Due to the presence of coding DNA

    • What removes all the RNA primers during end replication in somatic cells?

    <p>RNase H &amp; flap endonuclease 1 (FEN1)</p> Signup and view all the answers

    What fills the gap created by the removal of RNA primers during end replication in somatic cells?

    <p>Polymerase e (epsilon)</p> Signup and view all the answers

    Why can't the gap created at the 5' end of the lagging strand be filled with DNA by polymerase during end replication in somatic cells?

    <p>Absence of primer necessary for the polymerase to synthesize complementary DNA from the template strand</p> Signup and view all the answers

    What creates a permanent gap (overhangs) in somatic cells during end replication?

    <p>Absence of primer necessary for the polymerase to synthesize complementary DNA from the template strand</p> Signup and view all the answers

    Which cells can fill the final gap created at the 5' end of the lagging strand during end replication?

    <p>Germ, stem &amp; cancer cells</p> Signup and view all the answers

    What helps in synthesizing telomeric repeat (AGGGTT) DNA at the end of the lagging strand in germ, stem & cancer cells?

    <p>Telomerase</p> Signup and view all the answers

    What is the function of RNase H during end replication in somatic cells?

    <p>Removes RNA primers</p> Signup and view all the answers

    What is the function of flap endonuclease 1 (FEN1) during end replication in somatic cells?

    <p>Removes RNA primers</p> Signup and view all the answers

    What is the function of telomerase in germ, stem & cancer cells?

    <p>Helps in synthesizing telomeric repeat (AGGGTT) DNA at the end of the lagging strand</p> Signup and view all the answers

    What is a telomere?

    <p>A region at the end of chromosomes</p> Signup and view all the answers

    What are telomeres made of?

    <p>Repetitive sequences of non-coding DNA</p> Signup and view all the answers

    Why is replication at the chromosome end (telomere) always a problem in somatic cells?

    <p>Due to the end replication problem in the lagging strand</p> Signup and view all the answers

    What removes all the RNA primers during end replication in somatic cells?

    <p>RNase H &amp; flap endonuclease 1 (FEN1)</p> Signup and view all the answers

    What fills the gap created by the removal of RNA primers during end replication in somatic cells?

    <p>Polymerase e (epsilon)</p> Signup and view all the answers

    Why can't the gap created at the 5' end of the lagging strand be filled with DNA by polymerase during end replication in somatic cells?

    <p>Absence of primer necessary for the polymerase to synthesize complementary DNA from the template strand</p> Signup and view all the answers

    What creates a permanent gap (overhangs) in somatic cells during end replication?

    <p>Absence of primer necessary for the polymerase to synthesize complementary DNA from the template strand</p> Signup and view all the answers

    Which cells can fill the final gap created at the 5' end of the lagging strand during end replication?

    <p>Germ, stem &amp; cancer cells</p> Signup and view all the answers

    What helps in synthesizing telomeric repeat (AGGGTT) DNA at the end of the lagging strand in germ, stem & cancer cells?

    <p>Telomerase</p> Signup and view all the answers

    What is the function of RNase H during end replication in somatic cells?

    <p>Removes RNA primers</p> Signup and view all the answers

    What is the function of flap endonuclease 1 (FEN1) during end replication in somatic cells?

    <p>Removes RNA primers</p> Signup and view all the answers

    What is the function of telomerase in germ, stem & cancer cells?

    <p>Helps in synthesizing telomeric repeat (AGGGTT) DNA at the end of the lagging strand</p> Signup and view all the answers

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