Telomeres and Cell Division Quiz

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What is a telomere?

A type of DNA polymerase

A protein that aids in DNA replication

A type of RNA molecule

A region at the end of chromosomes (correct)

What are telomeres made of?

Proteins

Repetitive sequences of non-coding DNA (correct)

Repetitive sequences of coding DNA

Single-stranded RNA molecules

Why is replication at the chromosome end (telomere) always a problem in somatic cells?

Due to the presence of RNA primers

Due to the absence of telomerase

Due to the end replication problem in the lagging strand (correct)

Due to the presence of coding DNA

What removes all the RNA primers during end replication in somatic cells?

RNase H & flap endonuclease 1 (FEN1) Signup and view all the answers

What fills the gap created by the removal of RNA primers during end replication in somatic cells?

Polymerase e (epsilon) Signup and view all the answers

Why can't the gap created at the 5' end of the lagging strand be filled with DNA by polymerase during end replication in somatic cells?

Absence of primer necessary for the polymerase to synthesize complementary DNA from the template strand Signup and view all the answers

What creates a permanent gap (overhangs) in somatic cells during end replication?

Absence of primer necessary for the polymerase to synthesize complementary DNA from the template strand Signup and view all the answers

Which cells can fill the final gap created at the 5' end of the lagging strand during end replication?

Germ, stem & cancer cells Signup and view all the answers

What helps in synthesizing telomeric repeat (AGGGTT) DNA at the end of the lagging strand in germ, stem & cancer cells?

Telomerase Signup and view all the answers

What is the function of RNase H during end replication in somatic cells?

Removes RNA primers Signup and view all the answers

What is the function of flap endonuclease 1 (FEN1) during end replication in somatic cells?

Removes RNA primers Signup and view all the answers

What is the function of telomerase in germ, stem & cancer cells?

Helps in synthesizing telomeric repeat (AGGGTT) DNA at the end of the lagging strand Signup and view all the answers

What is a telomere?

A region at the end of chromosomes Signup and view all the answers

What are telomeres made of?

Repetitive sequences of non-coding DNA Signup and view all the answers

Why is replication at the chromosome end (telomere) always a problem in somatic cells?

Due to the end replication problem in the lagging strand Signup and view all the answers

What removes all the RNA primers during end replication in somatic cells?

RNase H & flap endonuclease 1 (FEN1) Signup and view all the answers

What fills the gap created by the removal of RNA primers during end replication in somatic cells?

Polymerase e (epsilon) Signup and view all the answers

Why can't the gap created at the 5' end of the lagging strand be filled with DNA by polymerase during end replication in somatic cells?

Absence of primer necessary for the polymerase to synthesize complementary DNA from the template strand Signup and view all the answers

What creates a permanent gap (overhangs) in somatic cells during end replication?

Absence of primer necessary for the polymerase to synthesize complementary DNA from the template strand Signup and view all the answers

Which cells can fill the final gap created at the 5' end of the lagging strand during end replication?

Germ, stem & cancer cells Signup and view all the answers

What helps in synthesizing telomeric repeat (AGGGTT) DNA at the end of the lagging strand in germ, stem & cancer cells?

Telomerase Signup and view all the answers

What is the function of RNase H during end replication in somatic cells?

Removes RNA primers Signup and view all the answers

What is the function of flap endonuclease 1 (FEN1) during end replication in somatic cells?

Removes RNA primers Signup and view all the answers

What is the function of telomerase in germ, stem & cancer cells?

Helps in synthesizing telomeric repeat (AGGGTT) DNA at the end of the lagging strand Signup and view all the answers

Telomeres and Cell Division Quiz

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Questions and Answers

What is a telomere?

What are telomeres made of?

Why is replication at the chromosome end (telomere) always a problem in somatic cells?

What removes all the RNA primers during end replication in somatic cells?

What fills the gap created by the removal of RNA primers during end replication in somatic cells?

Why can't the gap created at the 5' end of the lagging strand be filled with DNA by polymerase during end replication in somatic cells?

What creates a permanent gap (overhangs) in somatic cells during end replication?

Which cells can fill the final gap created at the 5' end of the lagging strand during end replication?

What helps in synthesizing telomeric repeat (AGGGTT) DNA at the end of the lagging strand in germ, stem & cancer cells?

What is the function of RNase H during end replication in somatic cells?

What is the function of flap endonuclease 1 (FEN1) during end replication in somatic cells?

What is the function of telomerase in germ, stem & cancer cells?

What is a telomere?

What are telomeres made of?

Why is replication at the chromosome end (telomere) always a problem in somatic cells?

What removes all the RNA primers during end replication in somatic cells?

What fills the gap created by the removal of RNA primers during end replication in somatic cells?

Why can't the gap created at the 5' end of the lagging strand be filled with DNA by polymerase during end replication in somatic cells?

What creates a permanent gap (overhangs) in somatic cells during end replication?

Which cells can fill the final gap created at the 5' end of the lagging strand during end replication?

What helps in synthesizing telomeric repeat (AGGGTT) DNA at the end of the lagging strand in germ, stem & cancer cells?

What is the function of RNase H during end replication in somatic cells?

What is the function of flap endonuclease 1 (FEN1) during end replication in somatic cells?

What is the function of telomerase in germ, stem & cancer cells?

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