5 Questions
What is the term for the partial or complete separation of the tablet top or bottom crown from the main body of the tablet?
Capping
What is one of the causes of capping during tablet processing?
Air entrapment in the granular material
What is the recommended solution for the capping problem during tablet processing?
Slow down the compression speed and decrease the main compression pressure
What type of properties of the formulation during and after compression can contribute to capping?
Deformational properties
What is the term used for the pressure greater than what can be relieved by the elastic recovery when punch pressure is removed?
Die wall pressure
Study Notes
Tablet Defects
- Capping: partial or complete separation of the tablet top or bottom crown from the main body of the tablet
Causes of Capping
- One of the causes of capping during tablet processing is over-lubrication
Solutions to Capping
- Recommended solution for the capping problem during tablet processing is optimal lubrication
Formulation Properties Contributing to Capping
- Properties of the formulation during and after compression that can contribute to capping include low hardness, high elasticity, and poor bonding
Compression Pressure
- Over-pressure: pressure greater than what can be relieved by the elastic recovery when punch pressure is removed
Test your knowledge of tablet formulation and manufacturing problems with this quiz. Identify common issues related to tablet processing, excipients, and other potential problems that can arise during the manufacturing and handling of tablets.
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