17 Questions
What is a possible reason for pitting on the surface of a tablet?
Insufficient lubricant in the granules
What is a characteristic of a rotary tablet machine?
It has a high output of 10,000 tablets/min
Why are special excipients required in certain tablet formulations?
Because colorants are not uniformly distributed
What is a characteristic of a single punch tablet machine?
It is composed of one set of punches and a die
What is a problem that can occur during tablet manufacture due to insufficient lubricant in the granules?
Pitting on the surface of the tablet
What is the purpose of the friability test in tablet quality control?
To determine the ability of the tablet to withstand mechanical stress
What is one of the defects that can be present in a tablet?
Cracks
What is the advantage of tablets that allows them to mask the unpleasant taste of drugs?
Improved patient acceptance
What is a requirement for an ideal tablet in terms of its size?
It must be of suitable size for ease of administration
What is a challenge in formulating and manufacturing tablets for certain drugs?
Drugs with poor wetting and slow dissolution
Why may some drugs require encapsulation or entrapment prior to compression?
To protect them from oxygen or moisture
What is a major disadvantage of using the slugging process for tablet production?
It requires specialized heavy-duty machines
Why is the direct compression method not suitable for high-dose drug formulations?
The high dose of the drug has poor compressibility
What is a potential tablet defect resulting from the direct compression method?
Segregation
What is a critical property of an ideal direct compression vehicle?
High flowability
What is a disadvantage of using the direct compression method for low-dose drug formulations?
Uniform distribution of the drug is not possible
What is an advantage of using the slugging process for tablet production?
It is suitable for heat and/or moisture sensitive materials
This quiz covers the manufacturing process of tablets, including the advantages and disadvantages of dry granulation and types of tableting presses.
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