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Pharmacy: Tablet Manufacturing Process

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Questions and Answers

What is a possible reason for pitting on the surface of a tablet?

Incorrect die shape and size

Insufficient lubricant in the granules (correct)

Poor binding properties of the excipient

High pressure during compression

What is a characteristic of a rotary tablet machine?

It has a high output of 10,000 tablets/min (correct)

It is composed of multiple sets of punches housed in a square die

It is used for small scale production

It is composed of a single set of punches and a die

Why are special excipients required in certain tablet formulations?

To improve the color of the tablet

Because colorants are not uniformly distributed (correct)

To increase the hardness of the tablet

To enhance the bioavailability of the active ingredient

What is a characteristic of a single punch tablet machine?

It is composed of one set of punches and a die Signup and view all the answers

What is a problem that can occur during tablet manufacture due to insufficient lubricant in the granules?

Pitting on the surface of the tablet Signup and view all the answers

What is the purpose of the friability test in tablet quality control?

To determine the ability of the tablet to withstand mechanical stress Signup and view all the answers

What is one of the defects that can be present in a tablet?

Cracks Signup and view all the answers

What is the advantage of tablets that allows them to mask the unpleasant taste of drugs?

Improved patient acceptance Signup and view all the answers

What is a requirement for an ideal tablet in terms of its size?

It must be of suitable size for ease of administration Signup and view all the answers

What is a challenge in formulating and manufacturing tablets for certain drugs?

Drugs with poor wetting and slow dissolution Signup and view all the answers

Why may some drugs require encapsulation or entrapment prior to compression?

To protect them from oxygen or moisture Signup and view all the answers

What is a major disadvantage of using the slugging process for tablet production?

It requires specialized heavy-duty machines Signup and view all the answers

Why is the direct compression method not suitable for high-dose drug formulations?

The high dose of the drug has poor compressibility Signup and view all the answers

What is a potential tablet defect resulting from the direct compression method?

Segregation Signup and view all the answers

What is a critical property of an ideal direct compression vehicle?

High flowability Signup and view all the answers

What is a disadvantage of using the direct compression method for low-dose drug formulations?

Uniform distribution of the drug is not possible Signup and view all the answers

What is an advantage of using the slugging process for tablet production?

It is suitable for heat and/or moisture sensitive materials Signup and view all the answers