Systemic Lupus Erythematosus (SLE) Pathophysiology

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What is the underlying mechanism of Systemic Lupus Erythematosus (SLE)?

Infectious disease caused by virus

Autoimmune reaction with T-cell activation

Type III hypersensitivity reaction (correct)

Type I hypersensitivity reaction

What is the hallmark of discoid lupus in Systemic Lupus Erythematosus (SLE)?

Red infiltrated plaques on the hands and feet

Painful joints in the morning

Swollen lymph nodes in the armpits

Red infiltrated plaques on the face, neck, and scalp (correct)

What is the diagnostic criterion for Systemic Lupus Erythematosus (SLE)?

3+ of clinical or antibody manifestations

4+ of clinical or antibody manifestations (correct)

5+ of clinical or antibody manifestations

6+ of clinical or antibody manifestations

What is the primary treatment for Systemic Lupus Erythematosus (SLE)?

Hydroxychloroquine and glucocorticoids Signup and view all the answers

What is a characteristic feature of Drug-induced Lupus?

Positive ANA and anti-histone Signup and view all the answers

What is a common manifestation of Neonatal Lupus?

Facial rash and anemia Signup and view all the answers

What is the primary role of Th1 cells in the context of autoimmune diseases?

To stimulate macrophages with cytokine releases Signup and view all the answers

Which of the following is NOT a characteristic feature of rheumatoid arthritis?

Asymmetric polyarthritis Signup and view all the answers

What is the primary mechanism of action of TNF-a inhibitors in the treatment of rheumatoid arthritis?

Blockade of TNF-a cytokine release Signup and view all the answers

Which of the following is a risk factor for the development of rheumatoid arthritis?

Smoking Signup and view all the answers

What is the primary pathophysiologic mechanism underlying gout?

Monosodium urate crystal deposition Signup and view all the answers

Which of the following medications is commonly used to treat gout?

Colchicine Signup and view all the answers

Which autoimmune disease is characterized by the presence of anti-U1RNP antibody?

Mixed Connective Tissue Disease (MCTD) Signup and view all the answers

What is the primary mechanism of action of TNF-a inhibitors in the treatment of Axial Spondylarthritis (SpA)?

Inhibition of TNF-a release Signup and view all the answers

Which of the following is a characteristic radiological finding in Axial Spondylarthritis (SpA)?

Syndesmophytes in the lumbar spine Signup and view all the answers

What is the strongest risk factor for developing Reactive Arthritis following a chlamydia infection?

Male gender Signup and view all the answers

Which of the following is a common feature of Arthritis associated with Inflammatory Bowel Disease (IBD)?

Enthesitis and dactylitis Signup and view all the answers

What is the primary goal of treating underlying Inflammatory Bowel Disease (IBD) in Arthritis associated with IBD?

Managing gastrointestinal symptoms Signup and view all the answers