Systemic Lupus Erythematosus (SLE) Pathophysiology
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Questions and Answers

What is the underlying mechanism of Systemic Lupus Erythematosus (SLE)?

  • Infectious disease caused by virus
  • Autoimmune reaction with T-cell activation
  • Type III hypersensitivity reaction (correct)
  • Type I hypersensitivity reaction

    • What is the hallmark of discoid lupus in Systemic Lupus Erythematosus (SLE)?

  • Red infiltrated plaques on the hands and feet
  • Painful joints in the morning
  • Swollen lymph nodes in the armpits
  • Red infiltrated plaques on the face, neck, and scalp (correct)

    • What is the diagnostic criterion for Systemic Lupus Erythematosus (SLE)?

  • 3+ of clinical or antibody manifestations
  • 4+ of clinical or antibody manifestations (correct)
  • 5+ of clinical or antibody manifestations
  • 6+ of clinical or antibody manifestations

    • What is the primary treatment for Systemic Lupus Erythematosus (SLE)?

    <p>Hydroxychloroquine and glucocorticoids</p> Signup and view all the answers

    What is a characteristic feature of Drug-induced Lupus?

    <p>Positive ANA and anti-histone</p> Signup and view all the answers

    What is a common manifestation of Neonatal Lupus?

    <p>Facial rash and anemia</p> Signup and view all the answers

    What is the primary role of Th1 cells in the context of autoimmune diseases?

    <p>To stimulate macrophages with cytokine releases</p> Signup and view all the answers

    Which of the following is NOT a characteristic feature of rheumatoid arthritis?

    <p>Asymmetric polyarthritis</p> Signup and view all the answers

    What is the primary mechanism of action of TNF-a inhibitors in the treatment of rheumatoid arthritis?

    <p>Blockade of TNF-a cytokine release</p> Signup and view all the answers

    Which of the following is a risk factor for the development of rheumatoid arthritis?

    <p>Smoking</p> Signup and view all the answers

    What is the primary pathophysiologic mechanism underlying gout?

    <p>Monosodium urate crystal deposition</p> Signup and view all the answers

    Which of the following medications is commonly used to treat gout?

    <p>Colchicine</p> Signup and view all the answers

    Which autoimmune disease is characterized by the presence of anti-U1RNP antibody?

    <p>Mixed Connective Tissue Disease (MCTD)</p> Signup and view all the answers

    What is the primary mechanism of action of TNF-a inhibitors in the treatment of Axial Spondylarthritis (SpA)?

    <p>Inhibition of TNF-a release</p> Signup and view all the answers

    Which of the following is a characteristic radiological finding in Axial Spondylarthritis (SpA)?

    <p>Syndesmophytes in the lumbar spine</p> Signup and view all the answers

    What is the strongest risk factor for developing Reactive Arthritis following a chlamydia infection?

    <p>Male gender</p> Signup and view all the answers

    Which of the following is a common feature of Arthritis associated with Inflammatory Bowel Disease (IBD)?

    <p>Enthesitis and dactylitis</p> Signup and view all the answers

    What is the primary goal of treating underlying Inflammatory Bowel Disease (IBD) in Arthritis associated with IBD?

    <p>Managing gastrointestinal symptoms</p> Signup and view all the answers

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