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Sulfonamide Prodrugs and Sulfones Quiz

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Questions and Answers

What is the reason for pyrazinamide being elevated to first-line status in short-term tuberculosis treatment regimens?

Its ability to inhibit mycolic acid biosynthesis in mycobacteria

Its tuberculocidal activity and low short-term toxicity (correct)

Its minimal side effects in long-term therapy

Its activity against metabolically inactive tubercle bacilli

What makes pyrazinamide unsuitable for long-term therapy?

Its bioactivation to pyrazinoic acid in the urine

Its ineffectiveness against metabolically inactive tubercle bacilli (correct)

Its high toxicity in short-term use

Its ability to penetrate inflamed meninges

Which condition should healthcare providers be cautious about when administering pyrazinamide?

Hyperthyroidism

Anemia

Hypertension

Hyperuricemia or gout (correct)

What is the reason behind pyrazinamide being recommended for the treatment of tuberculous meningitis?

Its penetration of inflamed meninges Signup and view all the answers

What is the primary mechanism of action of ethambutol against mycobacteria?

Inhibition of mycolic acid biosynthesis Signup and view all the answers

What distinguishes ethambutol from other drugs mentioned in terms of Mycolic acid biosynthesis?

It has no effect on mycolic acid biosynthesis in mycobacteria Signup and view all the answers

Which drug was discovered to have antitubercular properties in 1952?

Isoniazid Signup and view all the answers

Which compound is known for its ability to antagonize many sulfones?

Aminosalicylic acid Signup and view all the answers

What structure variation can give active compounds according to the text?

Substitution on both the 4- and 4’-amino functions Signup and view all the answers

Which of the following is NOT less effective than sulfonamides?

Pyrazinamide Signup and view all the answers

Which compound has a carboxylic acid at the amine side chain and is mainly used for intestinal infections?

Isoniazid Signup and view all the answers

'Sulfones' were used to treat what disease after finding sodium glucosulfone effective?

Leprosy Signup and view all the answers

What was the lead compound used in the development of penicillins?

Red dye Signup and view all the answers

Which compound showed in-vivo antibacterial activity despite being in-vitro inactive?

Prontosil Signup and view all the answers

In the context provided, which compound ushered in the concept of the prodrug?

Sulphanilamide Signup and view all the answers

What is the mode of action of sulfonamides based on the information provided?

Mimicking P-aminobenzoic acid (PABA) Signup and view all the answers

Which of the following classes of sulfonamides can be used for topical application?

None of the above Signup and view all the answers