17 Questions
What is the reason for pyrazinamide being elevated to first-line status in short-term tuberculosis treatment regimens?
Its tuberculocidal activity and low short-term toxicity
What makes pyrazinamide unsuitable for long-term therapy?
Its ineffectiveness against metabolically inactive tubercle bacilli
Which condition should healthcare providers be cautious about when administering pyrazinamide?
Hyperuricemia or gout
What is the reason behind pyrazinamide being recommended for the treatment of tuberculous meningitis?
Its penetration of inflamed meninges
What is the primary mechanism of action of ethambutol against mycobacteria?
Inhibition of mycolic acid biosynthesis
What distinguishes ethambutol from other drugs mentioned in terms of Mycolic acid biosynthesis?
It has no effect on mycolic acid biosynthesis in mycobacteria
Which drug was discovered to have antitubercular properties in 1952?
Isoniazid
Which compound is known for its ability to antagonize many sulfones?
Aminosalicylic acid
What structure variation can give active compounds according to the text?
Substitution on both the 4- and 4’-amino functions
Which of the following is NOT less effective than sulfonamides?
Pyrazinamide
Which compound has a carboxylic acid at the amine side chain and is mainly used for intestinal infections?
Isoniazid
'Sulfones' were used to treat what disease after finding sodium glucosulfone effective?
Leprosy
What was the lead compound used in the development of penicillins?
Red dye
Which compound showed in-vivo antibacterial activity despite being in-vitro inactive?
Prontosil
In the context provided, which compound ushered in the concept of the prodrug?
Sulphanilamide
What is the mode of action of sulfonamides based on the information provided?
Mimicking P-aminobenzoic acid (PABA)
Which of the following classes of sulfonamides can be used for topical application?
None of the above
Test your knowledge on sulfonamide prodrugs like Succinyl sulfathiazole which are mainly used for intestinal infections, as well as sulfones which are less effective than the sulfonamides. Learn about their properties and uses.
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