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Questions and Answers
What is the primary mechanism by which Stenotrophomonas malophilia strain K279a causes disease?
What is the primary mechanism by which Stenotrophomonas malophilia strain K279a causes disease?
What is the most common method of transmission for Stenotrophomonas?
What is the most common method of transmission for Stenotrophomonas?
What is the primary habitat of Stenotrophomonas?
What is the primary habitat of Stenotrophomonas?
What is the isolation rate of Stenotrophomonas in patients with cystic fibrosis?
What is the isolation rate of Stenotrophomonas in patients with cystic fibrosis?
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What is the significance of the whole genome shotgun sequence of S.maltophilia strain K279a?
What is the significance of the whole genome shotgun sequence of S.maltophilia strain K279a?
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What is the characteristic of Stenotrophomonas that makes outbreaks unlikely?
What is the characteristic of Stenotrophomonas that makes outbreaks unlikely?
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Study Notes
Stenotrophomonas Genomics
- The whole genome shotgun sequence of S.maltophilia strain K279a, the first Stenotrophomonas species isolated from a cystic fibrosis patient, has been determined.
- 64 validated genes support molecular mechanisms involved in pathogenesis and virulence of Stenotrophomonas spp.
- Identified genes encode for microbial secretion systems and regulatory proteins involved in bacterial adhesion, colonization, and intracellular growth.
Stenotrophomonas Characteristics
- Stenotrophomonas is an aerobic, nonfermentative, lactose-negative, oxidase-negative, catalase-positive, non-glucose-fermenting Gram-negative bacillus.
- It belongs to the family Xanthomonadaceae.
Epidemiology and Pathogenesis
- Stenotrophomonas has a worldwide distribution and is present in soil and water, suggesting low pathogenic potential in humans.
- It is a colonizer of the oropharynx, skin, and feces, with an isolation rate ranging from 6.1% to over 90% of patients with cystic fibrosis.
- Contamination of reagent water supply or increase in source transmission and/or outbreaks in healthcare facilities has been reported.
- Nosocomial spread is not common due to Stenotrophomonas' antimicrobial resistance profile.
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Description
Explore the genomic sequence of Stenotrophomonas maltophilia, its pathogenesis and virulence mechanisms, and characteristic genes involved in bacterial growth.
