Stenotrophomonas Infections and Antimicrobial Resistance

What is the family to which Stenotrophomonas belongs?

What is the primary reason for the low likelihood of outbreaks of Stenotrophomonas?

What is the characteristic of Stenotrophomonas in terms of glucose fermentation?

In which of the following environments is Stenotrophomonas commonly found?

What is the significance of Stenotrophomonas in patients with cystic fibrosis?

What is a reported mode of transmission of Stenotrophomonas?

What is the main focus of this review?

What is the significance of Stenotrophomonas maltophilia in recent years?

What complication has arisen from the recent reports of carbapenem-resistant S.maltophilia strains?

What has been determined for the first Stenotrophomonas species isolated from a cystic fibrosis patient?

What is the current state of evidence for the use of new antimicrobial drugs?

What is presented in this review regarding classical antimicrobial pharmacology?

What is discussed in this review regarding S.maltophilia strains?

What is supported by the genetic information contained in the validated genes of S.maltophilia strain K279a?

Introduction to Stenotrophomonas Infections

Stenotrophomonas species infections, particularly respiratory infections, require more comprehensive and reliable studies on the use of new antimicrobial drugs.
This review highlights the resistance determinants of S.maltophilia, re-examines classical antimicrobial pharmacology, and discusses optimal antibiotic doses and mortality.
Stenotrophomonas maltophilia is a relevant pathogen causing respiratory infections, with recent reports of carbapenem-resistant strains worldwide, leading to high mortality.

Overview of Stenotrophomonas Bacteria

The whole genome shotgun sequence of S.maltophilia strain K279a has been determined, providing insights into the molecular mechanisms of pathogenesis and virulence.
Identified genes encode for microbial secretion systems, regulatory proteins, and mechanisms involved in bacterial adhesion, colonization, and intracellular growth.
Stenotrophomonas is an aerobic, nonfermentative, lactose-negative, oxidase-negative, catalase-positive, non-glucose-fermenting Gram-negative bacillus in the family Xanthomonadaceae.
Stenotrophomonas has a worldwide distribution, is present in soil and water, and has a low pathogenic potential in humans.
It is a colonizer of the oropharynx, skin, and feces, with an isolation rate ranging from 6.1% to over 90% in patients with cystic fibrosis.
Contamination of the reagent water supply or transmission/outbreaks in healthcare facilities have been reported.

This quiz covers the antimicrobial resistance of Stenotrophomonas species, particularly in respiratory infections, and the optimal use of antibiotics. It also highlights the importance of understanding the pharmacology of these drugs.