Questions and Answers
What percentage of mortality rate is described in pan-resistant Stenotrophomonas infections, except in two case series with small samples?
What is the total number of deaths described in almost 10 different articles known at the time of this review?
What is the range of sample sizes in the described case series or case studies?
What factors have been identified as having potential influence on mortality rates in pan-resistant Stenotrophomonas infections?
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What percentage of variation in risk of death is explained through a model combining severity scores at HAI onset, clinical stability at specimen collection, microbiological culture site and positivity and non-fermenting MDRO?
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How many critically ill patients with XDR-ST infection were studied in the model that explained variation in risk of death?
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Study Notes
Pan-Resistant Stenotrophomonas Infections
- There is a lack of evidence on mortality rates in deadly pan-resistant Stenotrophomonas infections due to limited global case series with small samples of critically ill patients.
- Case series and case studies on pan-resistant Stenotrophomonas infections are uncontrolled, non-randomized, and retrospective, with modest sample sizes ranging from 10 to 46 patients.
- The global number of deaths from pan-resistant Stenotrophomonas infections is 51 cases, described in almost 10 different articles.
Mortality Rates
- Mortality in pan-resistant Stenotrophomonas infections is extremely high, exceeding 50% in most cases.
- Two case series with small samples reported lower mortality rates, ranging from 37% to 38%.
Risk Factors for Mortality
- Presence of bacteremia is a risk factor for mortality in pan-resistant Stenotrophomonas infections.
- Immunosuppression increases the risk of mortality in pan-resistant Stenotrophomonas infections.
- High severity scores at the time of hospital-acquired infection (HAI), such as SOFA or SAPS II, are associated with higher mortality rates.
- A model combining severity scores at HAI onset, clinical stability at specimen collection, microbiological culture site, and positivity and non-fermenting MDRO explained 73% of the variation in risk of death in 177 critically ill patients with XDR-ST infection.
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Description
This quiz covers the management of critically ill patients with pan-resistant Stenotrophomonas infections, including mortality rates, antibiotic strategies, and available evidence. It explores the complexity of treating this type of infection and the challenges healthcare professionals face.
