5 Questions
What is the effect of SGLT2 inhibitors on glucose and sodium reabsorption in the proximal kidney tubules?
Inhibit glucose and sodium reabsorption
In which patient population are SGLT2 inhibitors recommended to reduce morbidity and mortality?
Patients with symptomatic chronic HFrEF, regardless of the presence of type 2 diabetes
What should patients taking SGLT2 inhibitors be advised to avoid?
Abrupt changes in position
What is a potential side effect of SGLT2 inhibitors?
Orthostasis
What is the effect of SGLT2 inhibitors on arterial pressure?
Decrease arterial pressure
Study Notes
SGLT2 Inhibitors
- Inhibit glucose and sodium reabsorption in proximal kidney tubules, leading to osmotic diuresis and natriuresis
- Reduce arterial pressure
Uses of SGLT2 Inhibitors
- Recommended in patients with symptomatic chronic HFrEF to reduce morbidity and mortality
- Effective in patients with or without type 2 diabetes
- Dapagliflozin or empagliflozin are specific SGLT2 inhibitors used for this purpose
Precautions with SGLT2 Inhibitors
- Patients should avoid abrupt changes in position to minimize risk of orthostasis
- Overdiuresis increases the risk of orthostasis
This quiz covers the role of Sodium Glucose Cotransporter Type 2 inhibitors in reducing morbidity and mortality in patients with heart failure. Learn about their mechanism of action and recommended uses.
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