Sertraline (Zoloft) Overview and Uses
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Questions and Answers

What is the therapeutic class of Sertraline?

  • Selective serotonin reuptake inhibitor (SSRI) (correct)
  • Anxiolytic
  • Antidepressant (correct)
  • Mood stabilizer
  • What are the actions and uses of Sertraline?

    Sertraline is used for the treatment of depression, social anxiety disorder, obsessive-compulsive disorder, PTSD, and premenstrual dysphoric disorder.

    Sertraline should be administered in the ______ or evening.

    morning

    What are some adverse effects of Sertraline?

    <p>Adverse effects include agitation, insomnia, headache, dizziness, somnolence, and fatigue.</p> Signup and view all the answers

    It is safe to use Sertraline with MAOIs.

    <p>False</p> Signup and view all the answers

    What drug interactions should be avoided with Sertraline?

    <p>Highly protein bound medications such as digoxin and warfarin should be avoided due to toxicity risks.</p> Signup and view all the answers

    What is the recommended response to a Sertraline overdose?

    <p>Emergency medical attention is needed</p> Signup and view all the answers

    What herbal supplement should be used cautiously with Sertraline?

    <p>St. John's wort</p> Signup and view all the answers

    Match the following drugs with their respective brand names:

    <p>Citalopram = Celexa Escitalopram = Lexapro Fluoxetine = Prozac Fluvoxamine = Luvox Paroxetine = Paxil Vilazodone = Viibryd</p> Signup and view all the answers

    Study Notes

    Sertraline (Zoloft) Overview

    • Therapeutic class: Antidepressant
    • Pharmacologic class: Selective serotonin reuptake inhibitor (SSRI)

    Uses of Sertraline

    • Treats depression, social anxiety disorder, obsessive-compulsive disorder, PTSD, and premenstrual dysphoric disorder.
    • Enhances mood and improves affect; maximum effects observed after several weeks of treatment.

    Administration Guidelines

    • Recommended to take in the morning or evening.
    • When administering as an oral liquid, mix with water or citrus beverages.
    • Abrupt discontinuation may lead to withdrawal symptoms: nausea, sweating, agitation, tremors, insomnia, seizures.
    • Classified as Pregnancy Category C.

    Pharmacokinetics

    • Onset of action: 2-4 weeks.
    • Peak concentration: Unknown.
    • Duration of action: Variable due to extensive binding with serum proteins.

    Adverse Effects

    • Common side effects: agitation, insomnia, headache, dizziness, somnolence, fatigue.
    • Caution in patients with cardiac disease, liver impairment, seizure disorders, or suicidal ideation.
    • Black Box Warning: Increased risk of suicidal thoughts and behaviors, particularly in young patients.
    • Not approved for major depressive disorder in pediatric patients; approved for obsessive-compulsive disorder for children under 6.

    Contraindications

    • Avoid concomitant use with MAOIs or pimozide.
    • Discontinue Antabuse due to potential alcohol content in the medication.

    Drug Interactions

    • Caution with highly protein-bound medications (e.g., digoxin, warfarin) due to risk of toxicity and bleeding.
    • MAOIs may lead to severe adverse reactions, including neuroleptic malignant syndrome and serotonin syndrome (SES).
    • Use cautiously with other centrally acting drugs to prevent adverse CNS effects.

    Laboratory Considerations

    • May cause asymptomatic elevated liver function tests.
    • Slight decrease in uric acid levels can occur.

    Herbal and Food Interactions

    • Use caution with St. John's wort or L-tryptophan due to risk of serotonin syndrome.

    Overdose Management

    • No specific antidote; emergency medical attention and general support may be necessary.
    • Symptoms of overdose: nausea, vomiting, tremors, seizures, agitation, dizziness, hyperactivity, mydriasis, tachycardia, coma.

    Other SSRIs

    • Other similar drugs include citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac), fluvoxamine (Luvox), paroxetine (Paxil, Pexeva), and vilazodone (Viibryd).

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    Description

    This quiz covers the essential information regarding Sertraline, an antidepressant classified as a selective serotonin reuptake inhibitor (SSRI). It explores its uses, administration guidelines, pharmacokinetics, and potential adverse effects. Enhance your understanding of this medication's therapeutic applications and safety considerations.

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