Podcast Beta
Questions and Answers
What is the therapeutic class of Sertraline?
What are the actions and uses of Sertraline?
Sertraline is used for the treatment of depression, social anxiety disorder, obsessive-compulsive disorder, PTSD, and premenstrual dysphoric disorder.
Sertraline should be administered in the ______ or evening.
morning
What are some adverse effects of Sertraline?
Signup and view all the answers
It is safe to use Sertraline with MAOIs.
Signup and view all the answers
What drug interactions should be avoided with Sertraline?
Signup and view all the answers
What is the recommended response to a Sertraline overdose?
Signup and view all the answers
What herbal supplement should be used cautiously with Sertraline?
Signup and view all the answers
Match the following drugs with their respective brand names:
Signup and view all the answers
Study Notes
Sertraline (Zoloft) Overview
- Therapeutic class: Antidepressant
- Pharmacologic class: Selective serotonin reuptake inhibitor (SSRI)
Uses of Sertraline
- Treats depression, social anxiety disorder, obsessive-compulsive disorder, PTSD, and premenstrual dysphoric disorder.
- Enhances mood and improves affect; maximum effects observed after several weeks of treatment.
Administration Guidelines
- Recommended to take in the morning or evening.
- When administering as an oral liquid, mix with water or citrus beverages.
- Abrupt discontinuation may lead to withdrawal symptoms: nausea, sweating, agitation, tremors, insomnia, seizures.
- Classified as Pregnancy Category C.
Pharmacokinetics
- Onset of action: 2-4 weeks.
- Peak concentration: Unknown.
- Duration of action: Variable due to extensive binding with serum proteins.
Adverse Effects
- Common side effects: agitation, insomnia, headache, dizziness, somnolence, fatigue.
- Caution in patients with cardiac disease, liver impairment, seizure disorders, or suicidal ideation.
- Black Box Warning: Increased risk of suicidal thoughts and behaviors, particularly in young patients.
- Not approved for major depressive disorder in pediatric patients; approved for obsessive-compulsive disorder for children under 6.
Contraindications
- Avoid concomitant use with MAOIs or pimozide.
- Discontinue Antabuse due to potential alcohol content in the medication.
Drug Interactions
- Caution with highly protein-bound medications (e.g., digoxin, warfarin) due to risk of toxicity and bleeding.
- MAOIs may lead to severe adverse reactions, including neuroleptic malignant syndrome and serotonin syndrome (SES).
- Use cautiously with other centrally acting drugs to prevent adverse CNS effects.
Laboratory Considerations
- May cause asymptomatic elevated liver function tests.
- Slight decrease in uric acid levels can occur.
Herbal and Food Interactions
- Use caution with St. John's wort or L-tryptophan due to risk of serotonin syndrome.
Overdose Management
- No specific antidote; emergency medical attention and general support may be necessary.
- Symptoms of overdose: nausea, vomiting, tremors, seizures, agitation, dizziness, hyperactivity, mydriasis, tachycardia, coma.
Other SSRIs
- Other similar drugs include citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac), fluvoxamine (Luvox), paroxetine (Paxil, Pexeva), and vilazodone (Viibryd).
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Description
This quiz covers the essential information regarding Sertraline, an antidepressant classified as a selective serotonin reuptake inhibitor (SSRI). It explores its uses, administration guidelines, pharmacokinetics, and potential adverse effects. Enhance your understanding of this medication's therapeutic applications and safety considerations.
