12 Questions
What is the most common testicular germ cell neoplasm?
Seminoma
At what age does seminoma peak in terms of incidence?
34-45 years
What is a characteristic feature of seminomas on gross examination?
Soft, well-demarcated, gray-white tumors
Microscopically, how are seminomas characterized?
Small lobules with fibrous septa
What is a typical presentation of patients with seminoma?
Asymptomatic scrotal mass
Which hormone can be positively stained in as many as 25% of seminoma cases?
Human chorionic gonadotropin (hCG)
What is the age range in which embryonal carcinoma most frequently occurs?
25-35 years
Which of the following is a common clinical presentation of embryonal carcinoma?
Painful unilateral enlarging testicular mass
What is a characteristic microscopic feature of embryonal carcinoma cells?
Prominent nucleoli and basophilic cytoplasm
Which germ cell tumor is the most common primary testicular neoplasm in children younger than 3 years of age?
Yolk sac tumor
What histological feature is characteristic of yolk sac tumors (endodermal sinus tumors)?
Presence of primitive glomeruli (Schiller-Duvall bodies)
Which immunohistochemical marker can be demonstrated within the neoplastic cells in yolk sac tumors?
Alpha-fetoprotein (AFP)
Learn about the most common type of testicular germ cell neoplasm - seminoma. Understand its peak incidence, rarity before puberty, clinical presentation, and gross features. Ideal for medical students and healthcare professionals.
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