Rifampicin
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Questions and Answers

Which antibiotic also binds to the 50S ribosomal subunit and inhibits protein synthesis in bacteria?

  • Ciprofloxacin
  • Penicillin
  • Clindamycin (correct)
  • Vancomycin

    • What is the spectrum of activity of chloramphenicol?

  • Narrow spectrum - active against only G+ve bacteria
  • Broad spectrum - active against both G+ve and G-ve bacteria (correct)
  • Active against MRSA
  • Active against Ps.

    • Which bacterial enzyme is inhibited by chloramphenicol?

  • DNA polymerase
  • Peptidyltransferase (correct)
  • DNA gyrase
  • RNA polymerase

    • Which antibiotic is NOT affected by chloramphenicol resistance mechanisms?

    <p>Aminoglycosides (D)</p> Signup and view all the answers

    Which antibiotic is NOT mentioned as binding to the 50S ribosomal subunit?

    <p>Penicillins (C)</p> Signup and view all the answers

    Which bacterial organisms are NOT susceptible to chloramphenicol?

    <p>Ps. (D)</p> Signup and view all the answers

    What is the specific site on the 50S ribosomal subunit where chloramphenicol binds?

    <p>Peptidyltransferase site (D)</p> Signup and view all the answers

    Which of the following statements about chloramphenicol is correct?

    <p>Chloramphenicol resistance is caused by the acetylation of the hydroxy groups of chloramphenicol (C)</p> Signup and view all the answers

    What is the major route of elimination for chloramphenicol?

    <p>Biliary excretion (A)</p> Signup and view all the answers

    Which adverse reaction is most important with chloramphenicol use?

    <p>Bone marrow toxicity (B)</p> Signup and view all the answers

    What is the mechanism of action of chloramphenicol?

    <p>Inhibition of protein synthesis (B)</p> Signup and view all the answers

    Which of the following is a potential adverse effect of chloramphenicol in newborns?

    <p>Grey Baby Syndrome (A)</p> Signup and view all the answers

    What is the distribution of chloramphenicol in the body?

    <p>Widely distributed in body fluids (D)</p> Signup and view all the answers

    What is the most common route of excretion for chloramphenicol?

    <p>Renal excretion (A)</p> Signup and view all the answers

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