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Questions and Answers
Which of the following statements about rifamycins is correct?
Which of the following statements about rifamycins is correct?
- Rifamycins must be used with at least one other antituberculosis drug. (correct)
- Rifamycins can be used alone in treating tuberculosis.
- Rifampicin is not a rifamycin.
- Rifamycins are a group of antiviral drugs.
From which organism is rifampicin derived?
From which organism is rifampicin derived?
- Aspergillus
- Candida
- Penicillium
- Streptomyces (correct)
What is the primary mechanism of action of rifampicin?
What is the primary mechanism of action of rifampicin?
- Inhibition of DNA replication
- Inhibition of protein synthesis
- Inhibition of mRNA synthesis (correct)
- Disruption of cell wall synthesis
Why is rifampicin never given as a single agent in the treatment of active tuberculosis?
Why is rifampicin never given as a single agent in the treatment of active tuberculosis?
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Which subunit of bacterial RNA polymerase does rifampicin interact with?
Which subunit of bacterial RNA polymerase does rifampicin interact with?
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Which step of mRNA synthesis does rifampicin suppress?
Which step of mRNA synthesis does rifampicin suppress?
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Study Notes
Rifamycins
- Rifamycins are a group of macrocyclic antibiotics used as first-line drugs for tuberculosis.
- Includes Rifampicin, Rifabutin, and Rifapentine.
- Must be used in conjunction with at least one other antituberculosis drug to which the isolate is susceptible.
Rifampicin
- Derived from the soil mold Streptomyces.
- Has a broader antimicrobial activity than isoniazid.
- Used in the treatment of various bacterial infections.
- Never given as a single agent in the treatment of active tuberculosis due to rapid emergence of resistant strains.
Mechanism of Action
- Blocks RNA transcription by interacting with the beta subunit of bacterial DNA-dependent RNA polymerase.
- Inhibits mRNA synthesis by suppressing the initiation step.
- Specifically, Rifampicin binds with the beta subunit of DNA-dependent RNA polymerase, leading to inhibition of mRNA synthesis.
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Description
This quiz covers the use of rifamycins, including rifampicin, in the treatment of tuberculosis and other bacterial infections. Learn about their mechanisms, benefits, and importance in conjunction with other antituberculosis drugs.
