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Questions and Answers
What is the origin of Rifampicin?
Which rifamycin must NOT be given as a single agent in the treatment of active tuberculosis?
How does Rifampicin inhibit mRNA synthesis?
Which drug has a broader antimicrobial activity compared to Isoniazid?
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Which step of mRNA synthesis does Rifampicin suppress?
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What must always be used in conjunction with Rifamycin when treating tuberculosis?
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Study Notes
Rifamycins
- Rifamycins are a group of macrocyclic antibiotics used as first-line drugs for tuberculosis.
- Includes Rifampicin, Rifabutin, and Rifapentine.
- Must be used in conjunction with at least one other antituberculosis drug to which the isolate is susceptible.
Rifampicin
- Derived from the soil mold Streptomyces.
- Has a broader antimicrobial activity than isoniazid.
- Used in the treatment of various bacterial infections.
- Never given as a single agent in the treatment of active tuberculosis due to rapid emergence of resistant strains.
Mechanism of Action
- Blocks RNA transcription by interacting with the beta subunit of bacterial DNA-dependent RNA polymerase.
- Inhibits mRNA synthesis by suppressing the initiation step.
- Specifically, Rifampicin binds with the beta subunit of DNA-dependent RNA polymerase, leading to inhibition of mRNA synthesis.
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Description
Rifamycins are a group of antibiotics used to treat tuberculosis, including Rifampicin, Rifabutin, and Rifapentine. Learn about their uses, characteristics, and importance in treating TB.
